Volume 7.05 | Feb 10

Mesenchymal Cell News 7.05 February 10, 2015
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Mesenchymal Stem Cells Are Enriched in Head Neck Squamous Cell Carcinoma, Correlates with Tumor Size and Inhibit T-Cell Proliferation
Researchers evaluated the presence and features of mesenchymal stem cells isolated from human head neck squamous cell carcinoma. [Br J Cancer] Abstract
Learn More: UM729, a Novel Small Molecule for Ex Vivo Expansion of Human HSCs
 
PUBLICATIONS (Ranked by impact factor of the journal)
Recombinant Human Type II Collagen Hydrogel Provides a Xeno-Free 3D Micro-Environment for Chondrogenesis of Human Bone Marrow-Derived Mesenchymal Stromal Cells
Recombinant human type II collagen hydrogel was tested as a xeno-free micro-environment for the chondrogenesis of human bone marrow-derived mesenchymal stromal cells. [J Tissue Eng Regen Med] Abstract

Human Bone Marrow Mesenchymal Stem Cell-Derived Hepatocytes Express TIMP-4 and Follistatin
The mechanism by which human bone marrow mesenchymal stem cells (hBMSCs) differentiate into hepatocytes is still unclear. Researchers aimed to establish the specific characteristics of hBMSC-derived hepatocytes for future clinical applications [Liver Int] Abstract

Pre-Exposure of Human Adipose Mesenchymal Stem Cells to Soluble Factors Enhances Their Homing to Brain Cancer
Researchers report a reproducible, comprehensive, cell culture-based approach to enhance human adipose-derived mesenchymal stem cells’ engraftment to brain tumors. [Stem Cells Transl Med] Abstract

Prolonged Exposure to Hypoxic Milieu Improves the Osteogenic Potential of Adipose Derived Stem Cells
Scientists investigated whether prolonged exposure to hypoxia affects the osteogenic differentiation of adipose-derived stem cells. [J Cell Biochem] Abstract

PTEN/Akt-p27kip1 Signaling Promote the BM-MSCs Senescence and Apoptosis in SLE Patients
Researchers aimed to determine the molecular mechanism of senescent bone marrow-mesenchymal stem cells (BM-MSCs) from systemic lupus erythematosus (SLE) patients. They found that the expression of protein 27 kinase inhibition protein 1 (p27kip1) increased significantly, which was regulated by phosphatase and tensin homology deleted on chromosome ten (PTEN)/protein kinase B (Akt) signaling in SLE BM-MSCs. [J Cell Biochem] Abstract

Photo-Crosslinkable Biopolymers Targeting Stem Cell Adhesion and Proliferation: The Case Study of Gelatin and Starch-Based IPNs
The authors focused on the development of biomaterials that support the adhesion and the proliferation of adipose-tissue derived stem cells. An in vitro cellular assay revealed that the hydrogels developed are biocompatible and supported cell adhesion of adipose-tissue derived mesenchymal stem cells. [J Mater Sci Mater Med] Abstract

CXCL13 Promotes the Effect of Bone Marrow Mesenchymal Stem Cells (MSCs) on Tendon-Bone Healing in Rats and in C3HIOT1/2 Cells
MSCs significantly elevated the levels of ultimate load to failure, stiffness and stress in specimens of rats, the effects of which were enhanced by CXC chemokine ligand-13 (CXCL13). The expression of miR-23a was down-regulated and the protein of ERK1/2 level was up-regulated by CXCL13 treatment in both in vivo and in vitro experiments. [Int J Mol Sci] Abstract | Download Full Article

Double Labeling of Human Umbilical Cord Mesenchymal Stem Cells with Gd-DTPA and PKH26 and the Influence on Biological Characteristics of hUCMSCs
Scientists aimed to determine whether double labeling of human umbilical cord mesenchymal stem cells (hUCMSCs) with gadolinium-diethylene triamine penta-acetic acid (Gd-DTPA) and PKH26 influences their biological characteristics. [Int J Exp Pathol] Abstract

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REVIEWS
Signaling Pathways Involved in the Process of Mesenchymal Stem Cells Differentiating into Hepatocytes
Mechanisms of mesenchymal stem cells differentiating into hepatocytes, particularly the signaling pathways involved, have not as yet been completely illustrated. In this review, the authors focused on progress of signaling pathways associated with mesenchymal stem cells differentiating into hepatocytes along with the stepwise differentiation procedure. [Cell Prolif] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
 
INDUSTRY NEWS
Cynata Partners with UWA Centre for Cell Therapy and Regenerative Medicine
Cynata Therapeutics Ltd. announced that it has commenced a study to test the potential therapeutic efficacy of its Cymerus™ mesenchymal stem cells in an animal model of lung fibrosis. [Cynata Therapeutics Ltd.]
Press Release

BrainStorm Receives Notice of Allowance for its NurOwn™ Technology Platform from Israel’s Patent Office
BrainStorm Cell Therapeutics Inc. announced that it has received a notice of allowance from Israel’s Patent Office for its patent application titled “Isolated Population of Cells, Methods of Generating Same, and Uses Thereof in the Treatment of CNS Diseases.” [BrainStorm Cell Therapeutics Inc.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Keystone Symposium – Transcriptional and Epigenetic Influences on Stem Cell States
March 23-28, 2015
Steamboat Springs, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.
 
JOB OPPORTUNITIES
NEW Director – Vector Production (Sangamo BioSciences, Inc.)

NEW Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Research Associate, Mesenchymal (STEMCELL Technologies Inc.)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Researcher – Stem Cell Biology, Regeneration and Apoptosis (Israel Institute of Technology)

Postdoctoral Fellow – Bioinformatics and Stem Cell Biology (The University of Texas Medical School At Houston)

Postdoctoral Research Fellow – Regenerative Medicine (Loma Linda University)

Postdoctoral Fellow – Vascular Bioengineering (University of Pittsburgh)

Postdoctoral Research Assistant – Mesenchymal Stem Cell Epigenetics (University of Oxford)

Postdoctoral Fellow – Wnt Signaling in Development and Disease (Van Andel Research Institute)

Postdoctoral Fellowship – CNS Inflammation (Rutgers University)

Postdoctoral Position – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)


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