Volume 7.06 | Feb 17

Mesenchymal Cell News 7.06 February 17, 2015
Mesenchymal Cell News
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Distinct Mechanisms Regulating Mechanical Force-Induced Ca2+ Signals at the Plasma Membrane and the ER in Human MSCs
Scientists investigated the molecular mechanisms by which mechanical force regulates Ca2+ signaling at endoplasmic reticulum (ER) in human mesenchymal stem cells. [eLife] Full Article | Press Release
Free Cell Stem Cell Poster: Directed Differentiation of ESCs/iPSCs
PUBLICATIONS (Ranked by impact factor of the journal)
miR-30e Targets IGF2-Regulated Osteogenesis in Bone Marrow Derived Mesenchymal Stem Cells, Aortic Smooth Muscle Cells and ApoE-/- Mice
In vitro, miR-30e over-expression reduced the proliferation of mesenchymal stem cells (MSCs) and smooth muscle cells (SMCs) while increasing adipogenic differentiation of MSCs and smooth muscle differentiation of SMCs. [Cardiovasc Res] Abstract

Biomineralized Matrices Dominate Soluble Cues to Direct Osteogenic Differentiation of Human Mesenchymal Stem Cells through Adenosine Signaling
Researchers investigated whether a bone-specific calcium phosphate mineral environment could induce osteogenic differentiation of human mesenchymal stem cells, while inhibiting their adipogenic differentiation, in the presence of adipogenic-inducing medium. [Biomacromolecules] Abstract

Elucidating the Individual Effects of Calcium and Phosphate Ions on hMSCs by Using Composite Materials
Clinically relevant bone marrow derived human mesenchymal stromal cells (hMSCs) were cultured on composites and proliferation, osteogenic differentiation and ECM mineralization were investigated with time and were compared to plain PLA control particles. [Acta Biomater] Abstract

hiPS-MSCs Differentiation towards Fibroblasts on a 3D ECM Mimicking Scaffold
A PEG-fibrinogen hydrogel infiltrated with connective tissue growth factor scaffold was found not only biocompatible with human induced pluripotent stem cells derived mesenchymal stem cells (hiPS-MSCs), but also presented intriguingly strong fibroblastic commitments, to an extent comparable to the positive control. [Sci Rep] Full Article

Human Periapical Cyst-Mesenchymal Stem Cells Differentiate into Neuronal Cells
Periapical inflammatory cysts were compared with dental pulp to determine whether this tissue may be an alternative accessible tissue source of mesenchymal stem cells that retain the potential for neurogenic differentiation. [J Dent Res] Abstract

Contextual Niche Signals towards Colorectal Tumor Progression by Mesenchymal Stem Cell in the Mouse Xenograft Model
Scientists aimed to determine whether heterotypic interactions between mesenchymal stem/stromal cells and colon cancer cells can supply contextual signals towards tumor progression. [J Gastroenterol] Abstract

The Co-Transplantation of Bone Marrow Derived Mesenchymal Stem Cells Reduced Inflammation in Intramuscular Islet Transplantation
Researchers co-cultured murine islets with mesenchymal stem cells (MSCs) and then analyzed the morphological changes, viability, insulin-releasing function, and gene expression of the islets. The destruction of islets tended to be prevented by co-culture with MSCs. [PLoS One] Full Article

Alteration of Histone Acetylation Pattern during Long-Term Serum-Free Culture Conditions of Human Fetal Placental Mesenchymal Stem Cells
Alterations to histone acetylation and consequence on the expression pattern of mesenchymal stem cells (MSCs) derived from placenta of fetal origin (fPMSCs) following in vitro propagation under serum-free conditions were explored. Scientists show that fPMSCs maintain their MSC characteristics before they reach a senescent state. [PLoS One] Full Article

High Content and High throughput Screening to Assess the Angiogenic and Neurogenic Actions of Mesenchymal Stem Cells In Vitro
Scientists investigated the effect of mesenchymal stem cell conditioned media on in vitro assays of angiogenesis and nerve growth. They describe the use of two state of the art high content and high throughput cell analysis systems and compare them against manual analysis techniques. [Exp Cell Res] Abstract

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Mesenchymal Stromal Cells and Rheumatic Diseases: New Tools from Pathogenesis to Regenerative Therapies
In recent years, mesenchymal stromal cells (MSCs) have been investigated and tested as a new therapeutic tool for several clinical applications, including the treatment of different rheumatic diseases. Stem cell therapies may represent an innovative approach for the treatment of rheumatic diseases, especially for the forms that are not responsive to standard treatments or alternatively still lacking a definite therapy. [Cytotherapy] Abstract

Optimization of Pre-Transplantation Conditions to Enhance the Efficacy of Mesenchymal Stem Cells
In addition to ex vivo expansion in hypoxic culture condition using well defined media, the authors describe the potentials of transient adaptation of expanded mesenchymal stem cells in autologous serum supplemented medium prior to transplantation for long term regenerative benefits. [Int J Biol Sci] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
Improved Survival in Children with Graft versus Host Disease Who Respond to Mesoblast’s Cell Therapy
Results of 160 pediatric patients treated with Mesoblast’s proprietary allogeneic Tier 1 product candidate MSC-100-IV for severe steroid-resistant acute Graft Versus Host Disease were presented. [Press Release from Mesoblast Limited discussing research presented at the 2015 American Society for Blood and Marrow Transplantation Meeting, San Diego] Download Press Release

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TiGenix and Lonza Sign Agreement for the Manufacture of Stem Cell-Based Treatment
Lonza and TiGenix announced an agreement for the supply of TiGenix’s expanded adipose-derived stem cell product, Cx601. Under the agreement, Lonza will manufacture material for the Phase III trial of Cx601 in the US at Lonza’s cell therapy production facility in Walkersville, Maryland. [Lonza Group Ltd.] Press Release

Enrollment Begins European Knee Meniscus Injury Pilot Trial to Evaluate Cytori Cell Therapy
Cytori Therapeutics, Inc. announced that the first patient was enrolled and treated this week in a single arm, open label investigator initiated trial of Cytori Cell Therapy in patients undergoing surgery for traumatic meniscal injuries in the knee. [Cytori Therapeutics, Inc.] Press Release

Kaul Foundation Donates $7 Million for UAB Personalized Medicine Institute
The Hugh Kaul Foundation has donated $7 million to the University of Alabama at Birmingham (UAB) to establish the Hugh Kaul Personalized Medicine Institute at UAB. [University of Alabama at Birmingham]
Press Release
National Institutes of Health (United States)

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW The Biology of Regenerative Medicines
April 22-24, 2015
Cambridge, United Kingdom

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Instructor – Regulation of Stem Cell Differentiation in Vascular Disease (The University of Alabama at Birmingham)

Research Associate, Mesenchymal (STEMCELL Technologies Inc.)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Director – Vector Production (Sangamo BioSciences, Inc.)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Researcher – Stem Cell Biology, Regeneration and Apoptosis (Israel Institute of Technology)

Postdoctoral Fellow – Bioinformatics and Stem Cell Biology (The University of Texas Medical School At Houston)

Postdoctoral Research Fellow – Regenerative Medicine (Loma Linda University)

Postdoctoral Fellow – Vascular Bioengineering (University of Pittsburgh)

Postdoctoral Fellow – Wnt Signaling in Development and Disease (Van Andel Research Institute)

Postdoctoral Fellowship – CNS Inflammation (Rutgers University)

Postdoctoral Position – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

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