Volume 7.08 | Mar 3

Mesenchymal Cell News 7.08 March 3, 2015
Mesenchymal Cell News
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A Small-Molecule Screen for Enhanced Homing of Systemically Infused Cells
Pretreatment of mesenchymal stromal cells (MSCs) with Ro-31-8425 increased MSC firm adhesion to an intercellular adhesion molecule 1-coated substrate in vitro and enabled targeted delivery of systemically administered MSCs to inflamed sites in vivo in a CD11a-dependent manner. [Cell Rep]
Full Article | Graphical Abstract | Press Release
[Free On-Demand Webinar] Potential Applications of ALDH+ Cells in Regenerative Medicine - Watch Now.
PUBLICATIONS (Ranked by impact factor of the journal)
Tonsil-Derived Mesenchymal Stem Cells Ameliorate CCl4-Induced Liver Fibrosis in Mice via Autophagy Activation
Scientists used human palatine tonsil as a novel source of mesenchymal stem cells (T-MSCs) and examined their ability to differentiate into hepatocyte-like cells in vivo and in vitro. Carbon tetrachloride (CCl4) mouse model was used to investigate the ability of T-MSCs to home to the site of liver injury. [Sci Rep] Full Article

De-Regulated Expression of the BRG1 Chromatin Remodeling Factor in Bone Marrow Mesenchymal Stromal Cells Induces Senescence Associated with the Silencing of NANOG and Changes in the Levels of Chromatin Proteins
Researchers analyzed the effect of the de-regulation of the SWI/SNF chromatin remodeling complex in mesenchymal stromal cells through the silencing and up-regulation of BRG1, which is the ATPase subunit of the complex. [Cell Cycle] Abstract

Expansion, Harvest and Cryopreservation of Human Mesenchymal Stem Cells in a Serum-Free Microcarrier Process
Researchers ran a pilot study in the systematic development of serum-free human mesenchymal stem cell (hMSC) manufacturing process. Human bone-marrow derived hMSCs were expanded on fibronectin-coated, non-porous plastic microcarriers in 100 mL stirred spinner flasks in serum-free medium. [Biotechnol Bioeng] Abstract

Platelet-Derived Growth Factor-BB Enhances MSC-Mediated Cardioprotection via Suppression of miR-320 Expression
Human mesenchymal stem cells (MSCs), with or without PDGF preconditioning, were infused into the coronary circulation of isolated mouse hearts. The hearts that received PDGF-treated MSCs exhibited a greater functional recovery compared with naïve MSC-infused hearts, following ischemia/reperfusion injury. [Am J Physiol Heart Circ Physiol] Abstract

Autophagy and Mitochondrial Remodeling in Mouse Mesenchymal Stromal Cells Challenged with Staphylococcus epidermidis
Scientists demonstrated that in vitro challenge of mesenchymal stromal cells, i.e. colony-forming unit fibroblasts, with S. epidermidis can activate the autophagy pathway to execute antibacterial defense response, and that homoeostatic shift because of the bacteria-induced stress includes the mitochondrial remodeling and sequestration of compromised organelles via mitophagy. [J Cell Mol Med] Abstract

Adipose-Derived Mesenchymal Stem Cell Administration Does Not Improve Corneal Graft Survival Outcome
The effect of local and systemic injections of mesenchymal stem cells derived from adipose tissue into rabbit models of corneal allograft rejection with either normal-risk or high-risk vascularized corneal beds was investigated. [PLoS One] Full Article

Thermally Labile Components of Aqueous Humor Potently Induce Osteogenic Potential in Adipose-Derived Mesenchymal Stem Cells
Scientists cultured adipose-derived mesenchymal stem cells in the presence of 0, 5, 10, and 20% aqueous humor (AH) and assayed them for alkaline phosphatase (ALP) activity. They found ALP activity correlates with increasing AH concentrations from 5 to 20%, and that longer treatments result in increased ALP activity. [Exp Eye Res] Abstract

Generation of Insulin-Producing Cells from C3H10T1/2 Mesenchymal Progenitor Cells
Researchers investigated and compared the in vitro differentiation of rat mesenchymal stem cells and C3H10T1/2 cells into insulin-producing cells. These differentiated cells were transplanted into streptozotocin-induced diabetic mice and their biological functions were tested in vivo. [Gene] Abstract

Long-Term Expansion, Enhanced Chondrogenic Potential, and Suppression of Endochondral Ossification of Adult Human MSCs via WNT Signaling Modulation
Scientists report that the signaling protein WNT3A, in combination with FGF2, supports long-term expansion of human bone marrow-derived mesenchymal stem cells (MSCs). [Stem Cell Rep] Full Article

Achieve Superior Differentiation of Mouse MSC & MEF into Osteoblasts with the MesenCult™ Osteogenic Stimulatory Kit (Mouse)
Environmental Physical Cues Determine the Lineage Specification of Mesenchymal Stem Cells
Biophysical cues can initiate or strengthen the biochemical signaling for mesenchymal stem cells fate determination and differentiation. Physical properties of cellular environment direct the structural adaptation and functional coupling of the cells to their environment. [Biochim Biophys Acta] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
Ocata Therapeutics Receives Two New Patents for Immune-Modulatory Cell Technology
Ocata Therapeutics, Inc. announced that the United States Patent and Trademark Office issued two U.S. patents directed to the company’s hemangio-derived mesenchymal cells (HMCs). Ocata’s HMC technology introduces a new era of cell therapy for ophthalmic, autoimmune and inflammatory diseases. This development enables the generation of a potentially unlimited supply of potent HMCs from renewable pluripotent stem cell sources. [Ocata Therapeutics, Inc.] Press Release

Cynata Achieves Major Stem Cell Manufacturing Milestone
Australian stem cell and regenerative medicine company Cynata Therapeutics has achieved a world first breakthrough in the manufacture of stem cells and is now set to scale up manufacturing of its mesenchymal stem cells for therapeutic use. [Cynata Therapeutics (PR Newswire Association LLC)] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Stem Cell Summit 2015
April 27-29, 2015
Boston, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

NEW Postdoctoral Position – Pluripotent Stem Cells for Regenerative Medicine (Cells for Cells)

Research Associate: Mesenchymal (STEMCELL Technologies Inc.)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

PhD Positions – Cartilage Regeneration in Joints and Intervertebral Disc Diseases (University Medical Center Utrecht)

Instructor – Regulation of Stem Cell Differentiation in Vascular Disease (The University of Alabama at Birmingham)

Director – Vector Production (Sangamo BioSciences, Inc.)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Postdoctoral Position – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

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