Volume 7.09 | Mar 10

Mesenchymal Cell News 7.09 March 10, 2015
Mesenchymal Cell News
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Establishing Criteria for Human Mesenchymal Stem Cell Potency
Researchers identified critical determinants of mesenchymal stem cell potency using in vitro and in vivo attributes of cells isolated from the bone marrow of age- and sex-matched donors. [Stem Cells] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Heparanase Released from Mesenchymal Stem Cells Activates Integrin Beta1/HIF-2alpha/Flk-1 Signaling and Promotes Endothelial Cell Migration and Angiogenesis
Scientists elucidated the role of heparanase in the improved therapeutic properties of hypoxic preconditioning-mesenchymal stem cells and explored underlying mechanisms using an ischemic rat hindlimb model. [Stem Cells] Abstract | Full Article

OGP Functionalized Phenylalanine-Based Poly(Ester Urea) for Enhancing Osteoinductive Potential of Human Mesenchymal Stem Cells
Phenylalanine poly(ester urea)s (PEU) were modified by tethering osteogenic growth peptide (OGP) to tyrosine-based monomer subunits. These OGP-tethered PEUs were fabricated into porous scaffolds and cultured in vitro to examine their effect on differentiation of human mesenchymal stem cells toward the osteogenic lineage. [Biomacromolecules] Abstract

The Synergistic Effect of Micro-Topography and Biochemical Culture Environment to Promote Angiogenesis and Osteogenic Differentiation of Human Mesenchymal Stem Cells
Researchers investigated the combined effects of surface microtextures and biochemical supplements to achieve osteogenic differentiation of human mesenchymal stem cells and revascularization of the implants in vivo. [Acta Biomater] Abstract

Mesenchymal Stem Cells Alleviate Airway Inflammation and Emphysema in COPD through Down-Regulation of Cyclooxygenase-2 via p38 and ERK MAPK Pathways
Scientists showed that mesenchymal stem cell administration alleviated airway inflammation and emphysema through the down-regulation of cyclooxygenase-2 (COX-2) and COX-2-mediated prostaglandin E2 production, possibly through the effect on alveolar macrophages. [Sci Rep] Full Article

The Anti-Fibrotic Effects of Mesenchymal Stem Cells on Irradiated Lungs via Stimulating Endogenous Secretion of HGF and PGE2
Researchers attempted to use human adipose tissue-derived mesenchymal stem cells to prevent disease in Sprague-Dawley rats that received semi-thoracic irradiation. To investigate the specific roles of mesenchymal stem cells in ameliorating radiation-induced pulmonary fibrosis, they treated control groups of irradiated rats with human skin fibroblasts or phosphate-buffered saline. [Sci Rep] Full Article

Human Placenta-Derived CD146-Positive Mesenchymal Stromal Cells Display a Distinct Osteogenic Differentiation Potential
Scientists investigated if expression of CD146 on mesenchymal stromal cells (MSC) from placenta correlates with a similar osteogenic differentiation potential. The MSC were isolated specifically from the endometrial and fetal parts of human term placenta and expanded in separate cultures, and compared to MSC from bone marrow as controls. [Stem Cells Dev] Abstract

Peripheral Blood-Derived Mesenchymal Stem Cells: Candidate Cells Responsible for Healing Critical-Sized Calvarial Bone Defects
Scientists present a coculture system that routinely produces a group of cells from adult peripheral blood. Treatment with these cells enhanced healing of critical-size bone defects in the mouse calvarium, a proof of principle that peripheral blood-derived cells can be used to heal bone defects. [Stem Cells Transl Med] Abstract

Effects of the 1,4-Dihydropyridine L-Type Calcium Channel Blocker Benidipine on Bone Marrow Stromal Cells
Researchers investigated the effect of the antihypertensive drug benidipine on bone marrow stromal cell differentiation into osteoblasts and bone formation under osteoporotic conditions. [Cell Tissue Res] Abstract

Clumps of a Mesenchymal Stromal Cell/Extracellular Matrix Complex Can Be a Novel Tissue Engineering Therapy for Bone Regeneration
The biological properties of mesenchymal stromal cell/extracellular matrix complex were assessed in vitro and their bone regenerative activity was tested by use of a rat calvarial defect model. [Cytotherapy] Abstract

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The Pivotal Role of PDGF and Its Receptor Isoforms in Adipose-Derived Stem Cells
The authors summarized previous reports on the expression and functional roles of platelet-derived growth factor (PDGF) and its receptor isoforms. In addition, the examined findings pertaining to underlying molecular mechanisms and signaling pathways with special focus on PDGF-D/PDGFRβ. [Histol Histopathol]
Abstract | Full Article

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Athersys and Chugai Enter License Agreement and Collaboration to Develop MultiStem® Cell Therapy for Ischemic Stroke in Japan
Athersys, Inc. and Chugai Pharmaceutical Co., Ltd. have announced a partnership and license agreement to exclusively develop and commercialize MultiStem® cell therapy for ischemic stroke in Japan. [Athersys, Inc.] Press Release

Louis Simpson and Kimberly Querrey Make $92 Million Gift to Northwestern for Biomedical Research
Northwestern University Trustee and alumnus Louis A. Simpson and his spouse Kimberly K. Querrey have made an additional $92 million gift to Northwestern University in support of the University’s biomedical research programs at Northwestern University Feinberg School of Medicine. [Northwestern University] Press Release

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Therapeutic Goods Administration (Australia)
NEW Regenerative Medicine Workshop at Hilton Head
May 13-16, 2015
Hilton Head Island, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Postdoctoral Researcher – In Vivo Properties of Mesenchymal Stem and Progenitor Cells (Karolinska Institute)

NEW Manufacturing Manager – Cell Therapy (Opexa Therapeutics)

Research Associate: Mesenchymal (STEMCELL Technologies Inc.)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

Postdoctoral Position – Pluripotent Stem Cells for Regenerative Medicine (Cells for Cells)

PhD Positions – Cartilage Regeneration in Joints and Intervertebral Disc Diseases (University Medical Center Utrecht)

Instructor – Regulation of Stem Cell Differentiation in Vascular Disease (The University of Alabama at Birmingham)

Director – Vector Production (Sangamo BioSciences, Inc.)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Postdoctoral Position – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

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