Volume 7.11 | Mar 24

Mesenchymal Cell News 7.11 March 24, 2015
Mesenchymal Cell News
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The Suture Provides a Niche for Mesenchymal Stem Cells of Craniofacial Bones
Scientists identified ​Gli1+ cells within the suture mesenchyme as the main mesenchymal stem cell population for craniofacial bones. They are not associated with vasculature, give rise to all craniofacial bones in the adult and are activated during injury repair. [Nat Cell Biol] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Adipose Tissue-Derived Mesenchymal Stem Cells Attenuate Pulmonary Infection Caused by Pseudomonas aeruginosa via Inhibiting Overproduction of Prostaglandin E2
The therapeutic and mechanistic effects of adipose tissue-derived mesenchymal stem cells on P. aeruginosa pulmonary infection were evaluated in a murine model of P. aeruginosa pneumonia. [Stem Cells] Abstract

Natural Assembly of Platelet Lysate-Loaded Nanocarriers into Enriched 3D Hydrogels for Cartilage Regeneration
In vitro release studies were carried out focusing on the quantification of PDGF-BB and TGF-β1 growth factors. Human adipose derived stem cells were entrapped in 3D hydrogels and cultured in vitro under chondrogenic stimulus, in order to assess their potential use for cartilage regeneration. [Acta Biomater] Abstract

Differentiation Potential of Human Chorion-Derived Mesenchymal Stem Cells into Motor Neuron-Like Cells in Two- and Three-Dimensional Culture Systems
Since there is no report on potential of human chorion-derived mesenchymal stem cells (C-MSCs) to differentiate into motor neuron cells in two- and three-dimensional culture systems, scientists set out to determine the effect of retinoic acid and sonic hedgehog on differentiation of human C-MSCs into motor neuron-like cells cultured on tissue culture plates and electrospun nanofibrous gelatin scaffold. [Mol Neurobiol] Abstract

Extracellular Vesicles Secreted by Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stromal Cells Fail to Suppress Lymphocyte Proliferation
Researchers compared the immunosuppressive potency of mesenchymal stromal cells derived from bone marrow and adipose tissue, with their secreted extracellular vesicles in a standardized lymphocyte proliferation assay. [Stem Cells Dev] Abstract

Three-Dimensional Differentiation of Adipose-Derived Mesenchymal Stem Cells into Insulin-Producing Cells
Researchers evaluated the collagen/hyaluronic acid scaffold effect on the differentiation of insulin-producing cells from adipose-derived mesenchymal stem cells. Adipose-derived mesenchymal stem cells were cultured and seeded in a collagen/hyaluronic acid scaffold and then treated with induction media. [Cell Tissue Res] Abstract

Intravenous Delivery of Adipose-Derived Mesenchymal Stromal Cells Attenuates Acute Radiation-Induced Lung Injury in Rats
Researchers evaluated the therapeutic capacity of adipose-derived mesenchymal stromal cells (Ad-MSCs) to heal acute radiation-induced lung injury (RILI) in rats. Intravenous delivery of Ad-MSCs attenuated acute RILI. [Cytotherapy] Abstract

Tonsil-Derived Mesenchymal Stromal Cells Produce CXCR2-Binding Chemokines and Acquire Follicular Dendritic Cell-Like Phenotypes under TLR3 Stimulation
Scientists analyzed the expression profile of Toll-like receptors (TLRs) in mesenchymal stromal cells from human tonsils (T-MSCs) and stimulated the T-MSCs with TLR agonists. TLR3 stimuli induced C-C chemokine receptor type 6 expression in T-MSCs after 24 hours. [Cytokine] Abstract

Buyang Huanwu Decoction (BYHWD) Enhances Angiogenic Effect of Mesenchymal Stem Cell by Upregulating VEGF Expression after Focal Cerebral Ischemia
Researchers aimed to clarify the mechanism of BYHWD on angiogenesis mediated by mesenchymal stem cells (MSCs). Exosomes from MSCs and MSCs treated by BYHWD induced elevated microRNA (miRNA)-126 expression and reduced miR-221 and miR-222 expression. [J Mol Neurosci] Abstract

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Mesenchymal Stem Cell Derived Extracellular Vesicles: Towards Cell-Free Therapeutic Applications
The authors review current knowledge related to the potential use of mesenchymal stem cell-derived extracellular vesicles (EVs) in various diseases and discuss the promising future for EVs as an alternative, cell-free therapy. [Mol Ther] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
Bone Therapeutics Treats First Patients in ALLOB® Phase IIa Spinal Fusion Trial
Bone Therapeutics announced that the first four patients in the Phase IIa proof-of-concept study for spinal fusion procedures have been treated with Bone Therapeutics’ allogeneic osteoblastic cell therapy product, ALLOB®. [Bone Therapeutics S.A.] Press Release

City of Hope Launches Stem Cell Therapy Clinic to Fight Incurable Disease in New Ways
The City of Hope officially opened the Alpha Clinic for Cell Therapy and Innovation, for patients battling cancer and other life-threatening diseases have another option: stem cell-based therapy. The Alpha Clinic is funded by an $8 million, five-year grant from the California Institute for Regenerative Medicine that will be supplemented by matching funds from City of Hope. [City of Hope] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 21st ISCT Annual Meeting
May 27-30, 2015
Las Vegas, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Cell Culture Specialist – Mesenchymal Stem Cell and Neural Stem Cell Cultures (Tisch MS Research Center of New York)

Research Associate: Mesenchymal (STEMCELL Technologies Inc.)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Position – New Therapeutic Targets against Sarcoma Initiating Cells (The University Institute of Oncology of Asturias [IUOPA])

Manufacturing Manager – Cell Therapy (Opexa Therapeutics)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

Postdoctoral Position – Pluripotent Stem Cells for Regenerative Medicine (Cells for Cells)

PhD Positions – Cartilage Regeneration in Joints and Intervertebral Disc Diseases (University Medical Center Utrecht)

Instructor – Regulation of Stem Cell Differentiation in Vascular Disease (The University of Alabama at Birmingham)

Director – Vector Production (Sangamo BioSciences, Inc.)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Postdoctoral Position – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

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