Ex-Vivo Induced Regulatory Human/Murine Mesenchymal Stem Cells as Immune Modulators
Scientists established an ex-vivo immunomodulatory triple combination treatment for mesenchymal stem cells (MSCs), using IFNγ, TGFβ and kynurenine. They showed that pre-treated MSCs acquire an immunomodulatory phenotype, have improved regulatory functions, and up-regulate the expression of iNOS, IDO, COX2, HO-1, LIF and PD-L1. [Stem Cells] Abstract
Hepatocyte Growth Factor Gene-Modified Mesenchymal Stem Cells Augment Sinonasal Wound Healing
Scientists investigated the effects of hepatocyte growth factor transgenic mesenchymal stem cells (HGF-MSCs) on wound healing in the sinonasal mucosa and nasal epithelial cells. They also sought to determine whether HGF-MSCs and MSCs can migrate into the injured mucosa and differentiate into ciliated cells. [Stem Cells Dev] Abstract
Affect of Antidepressants on the In Vitro Differentiation of Rat Bone Marrow Mesenchymal Stem Cells into Neuronal Cells
The authors investigated how the antidepressants imipramine, desipramine, fluoxetine and tianeptine affect the differentiation of rat mesenchymal stem cells. Furthermore, they presented differentiation cocktails using a cortex astrocyte-conditioned medium separately or in conjunction with each of the antidepressants and investigated their additive effect on the efficiency of differentiation. [Eur J Pharm Sci] Abstract
Pericytes, Mesenchymal Stem Cells and Their Contributions to Tissue Repair
The authors summarize the recent evidence supporting the use of endogenously mobilised stem cell populations to enhance tissue repair along with the use of mesenchymal stem cells and pericytes in the development of engineered tissues. [Pharmacol Ther] Abstract
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INDUSTRY NEWS
Leading Biotech Firm Invests $1 Million into Biomedical Engineering at UF
The biotechnology company BioD has committed $1 million to the University of Florida J. Crayton Pruitt Family Department of Biomedical Engineering. The funding will be used to establish the Tim Brahm Endowed Term Professorship in Biomedical Engineering. [University of Florida] Press Release
£25.7 Million to Create Research Powerhouse
A £25.7 million funding boost will advance biological research and aid the quest for new therapies to treat damaged tissues. The investment by the UK Government will enable the University of Edinburgh to create a new biology complex with world-leading laboratory space for 350 researchers and to establish a new Centre for Tissue Repair. [The University of Edinburgh] Press Release
Clinical Trial Uses Patients’ Own Cells for Personalized Treatment after Bone Marrow Transplant
An innovative clinical trial using the science of “personalized” cellular therapy has begun enrolling children and adults suffering from graft-versus-host-disease (GvHD). By infusing large doses of personalized bone marrow cells into bone marrow transplant recipients, the physician-researchers aim to target sites of inflammation, potentially reducing GvHD in the intestine, liver and skin and limiting long-term organ damage. [Emory University] Press Release
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