Volume 7.16 | Apr 28

Mesenchymal Cell News 7.16 April 28, 2015
Mesenchymal Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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AKI Recovery Induced by Mesenchymal Stromal Cell-Derived Extracellular Vesicles Carrying MicroRNAs
Researchers generated mesenchymal stromal cells depleted of Drosha to alter microRNA expression. Drosha-knockdown cells produced extracellular vesicles that did not differ from those of wild-type cells in quantity, surface molecule expression, and internalization within renal tubular epithelial cells. [J Am Soc Nephrol] Abstract
Achieve Superior Differentiation of Mouse MSC & MEF into Osteoblasts with the MesenCult™ Osteogenic Stimulatory Kit (Mouse)
PUBLICATIONS (Ranked by impact factor of the journal)
Mesenchymal Stromal Cells Derived from Crohn’s Patients Deploy Indoleamine 2,3-Dioxygenase Mediated Immune Suppression, Independent of Autophagy
Scientists demonstrated no quantitative difference in phenotype, in vitro growth kinetics and molecular signatures to IFNγ between mesenchymal stromal cells (MSCs) derived from Crohn’s Disease (CD) and healthy individuals. CD MSCs were indistinguishable from those derived from healthy controls at inhibiting T cell proliferation through an indoleamine 2,3-dioxygenase dependent mechanism. [Mol Ther] Abstract

Synergistic Protection of N-Acetylcysteine and Ascorbic Acid 2-Phosphate on Human Mesenchymal Stem Cells against Mitoptosis, Necroptosis and Apoptosis
By using a systematic analysis, scientists revealed the mechanism of synergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells that were under H2O2-induced oxidative stress. [Sci Rep] Full Article

Hypoxic Culture of Bone Marrow-Derived Mesenchymal Stromal Stem Cells Differentially Enhances In Vitro Chondrogenesis within Cell-Seeded Collagen and Hyaluronic Acid Porous Scaffolds
The authors assessed the effect of hypoxia on in vitro bone marrow mesenchymal stromal stem cell chondrogenesis within clinically approved porous scaffolds composed of collagen and hyaluronic acid. [Stem Cell Res Ther] Abstract | Full Article

Macrophage Migration Inhibitory Factor Confers Resistance to Senescence through CD74-Dependent AMPK-FOXO3a Signaling in Mesenchymal Stem Cells
Investigators found that mesenchymal stem cells (MSCs) isolated from the bone marrow of aged rats displayed reduced proliferative capacity, impaired ability to mediate paracrine signaling, and lower resistance to hypoxia/serum deprivation-induced apoptosis, when compared to younger MSCs. [Stem Cell Res Ther] Abstract | Full Article

Antagonizing Effects of Aspartic Acid against Ultraviolet A-Induced Downregulation of the Stemness of Human Adipose Tissue-Derived Mesenchymal Stem Cells
The authors investigated effects of aspartic acid on ultraviolet A irradiation-induced damages in the stemness properties of human adipose tissue-derived mesenchymal stem cells. [PLoS One] Full Article

Melatonin Pre-Treatment of Human Adipose Tissue-Derived Mesenchymal Stromal Cells Enhances their Pro-Survival and Protective Effects on Human Kidney Cells
Researchers investigated the action of melatonin on adipose tissue-derived mesenchymal stromal cells (hASCs), as well as the effect of the resulting hASCs conditioned media on human kidney cells exposed to oxidative and apoptotic injury-provoking doses of cisplatin. [Am J Physiol Renal Physiol] Abstract

Periostin of Human Periodontal Ligament Fibroblasts Promotes Migration of Human Mesenchymal Stem Cell through the αvβ3 Integrin/FAK/PI3K/Akt Pathway
Researchers examined whether human periodontal ligament fibroblasts with high levels of periostin expression promoted the migration of human bone marrow mesenchymal stem cells. [J Periodontal Res] Abstract

Bone Marrow and Adipose-Derived Mesenchymal Stem Cells Alleviate Methotrexate-Induced Pulmonary Fibrosis in Rat: Comparison with Dexamethasone
Scientists examined the therapeutic effects of bone marrow mesenchymal stem cells and adipose-derived mesenchymal stem cells in methotrexate-induced pulmonary fibrosis in rats as compared with dexamethasone. [J Biochem Mol Toxicol] Abstract

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The Endometrium as a Source of Mesenchymal Stem Cells for Regenerative Medicine
The endometrium has emerged as an attractive novel source of adult stem cells that are easily accessed and demonstrate remarkable differentiation capacity. The authors summarize current understanding of endometrial stem cells and their therapeutic potential in regenerative medicine. [Biol Reprod] Abstract | Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
BrainStorm’s NurOwn® Demonstrates a Statistically Significant Effect in ALS Patients
BrainStorm Cell Therapeutics Inc. presented results from its Phase IIa study of NurOwn® in amyotrophic lateral sclerosis (ALS) at a poster session. [Press release from BrainStorm Cell Therapeutics Inc. discussing research presented at the American Academy of Neurology Annual Meeting, Washington D.C.] Press Release

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Regeneus Receives Approval for Progenza Stem Cell Trial for Osteoarthritis
Regeneus announced that it has received ethics approval for a clinical trial of its new off-the-shelf allogeneic stem cell treatment, known as Progenza, for patients with knee osteoarthritis. [Regeneus Ltd] Press Release

apceth Names Ulrike Verzetnitsch as Chief Technical Officer
The cell therapy company apceth GmbH & Co. KG is continuing to expand its senior management team and has announced the appointment of Ulrike Verzetnitsch as Chief Technical Officer with immediate effect. [apceth GmbH & Co. KG] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Cells: From Robert Hooke to Cell Therapy – A 350 Year Journey
October 5-6, 2015
London, United Kingdom

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Tenure-Track Faculty Positions – Cellular and Molecular Medicine (University of Ottawa)

Research Associate: Mesenchymal (STEMCELL Technologies Inc.)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Assistant/Associate/Full Professor – Stem Cell Biology & Regenerative Medicine (University of Illinois Chicago College of Medicine)

PhD Position – Biomaterials & Regenerative Medicine (Florida Atlantic University)

Faculty Positions – Stem Cell & Regenerative Medicine (The University of Texas Medical School at Houston)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

PhD Positions – Cartilage Regeneration in Joints and Intervertebral Disc Diseases (AO Research Institute)

Postdoctoral Fellowship – Hematology, Immunology, Stem Cell Transplantation, Cancer Therapeutics (The Research Institute at Nationwide Children’s Hospital)

Cell Culture Specialist – Mesenchymal Stem Cell and Neural Stem Cell Cultures (Tisch MS Research Center of New York)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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