Volume 7.17 | May 5

Mesenchymal Cell News 7.17 May 5, 2015
Mesenchymal Cell News
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Placental Mesenchymal Stromal Cells Rescue Ambulation in Ovine Myelomeningocele
Researchers demonstrated that using early gestation human placenta-derived mesenchymal stromal cells (PMSCs) to augment in utero repair of myelomeningocele (MMC) results in significant and consistent improvement in neurologic function at birth in the rigorous fetal ovine model of MMC. In vitro, human PMSCs expressed characteristic MSC markers and trilineage differentiation potential. [Stem Cells Transl Med]
Abstract | Press Release | Video
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PUBLICATIONS (Ranked by impact factor of the journal)
Bone Marrow-Derived Mesenchymal Stromal Cell Treatment in Patients with Severe Ischemic Heart Failure: A Randomized Placebo-Controlled Trial (MSC-HF Trial)
Researchers studied effects of intra-myocardial autologous bone marrow-derived mesenchymal stromal cells (MSCs) treatment in patients with severe ischemic heart failure. The MSC-HF trial was a randomized, double-blind, placebo-controlled trial. Patients were randomized 2:1 to intra-myocardial injections of MSC or placebo, respectively. [Eur Heart J] Abstract

MicroRNA Levels as Prognostic Markers for the Differentiation Potential of Human Mesenchymal Stromal Cell Donors
Scientists showed that microRNA expression levels are effective for distinguishing donors with high differentiation potential from low differentiation potential. Twenty human mesenchymal stromal/stem cell donors were initially tested for marker expression and differentiation potential. [Stem Cells Dev] Abstract

Phase I Trial of Repeated Intrathecal Autologous Bone Marrow-Derived Mesenchymal Stromal Cells in Amyotrophic Lateral Sclerosis
The authors evaluated the safety of two repeated intrathecal injections of autologous bone marrow-derived mesenchymal stromal cells in amyotrophic lateral sclerosis patients. [Stem Cells Transl Med] Abstract

HIF-1α as a Regulator of BMP2-Induced Chondrogenic Differentiation, Osteogenic Differentiation, and Endochondral Ossification in Stem Cells
Hypoxia inducible factor, or (HIF)-1α, was determined to be a regulator of bone morphogenetic protein 2 (BMP2)-induced chondrogenic differentiation, osteogenic differentiation, and endochondral bone formation. BMP2 was used to induce chondrogenic and osteogenic differentiation in stem cells and fetal limb development. [Cell Physiol Biochem] Full Article

Effects of Donor Age, Long-Term Passage Culture, and Cryopreservation on Tonsil-Derived Mesenchymal Stem Cells
Tonsil-derived mesenchymal stem cells (T-MSCs) were isolated from tonsillar tissue of 20 patients undergoing tonsillectomy. The authors evaluated the effects of donor-age, long-term passage, and cryopreservation on the morphology, surface markers, proliferation potential and differentiation capacities of T-MSCs. [Cell Physiol Biochem] Full Article

Metabolic and Pancreatic Effects of Bone Marrow Mesenchymal Stem Cells Transplantation in Mice Fed High-Fat Diet
Scientists investigated the effects of multiple infusions of allogeneic mesenchymal stem cells on glucose homeostasis and morphometry of pancreatic islets in high- fat diet fed mice. [PLoS One] Full Article

Increased In Vitro Osteopotential in SHED Associated with Higher IGF2 Expression when Compared with hASCs
Scientists showed that mesenchymal stem cells (MSCs) from human deciduous teeth (SHED) have an intrinsically higher osteogenic potential when compared with MSCs from human adipose tissue (hASCs) under the same in vitro controlled induction system. [Stem Cell Rev] Abstract

Sry-Type HMG Box 18 Contributes to the Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells to Endothelial Cells
The authors demonstrated that vascular endothelial growth factor (VEGF)-165 mediates mesenchymal stem cell differentiation into endothelial cells (ECs) via VEGFR-2-dependent induction of Sry-type HMG box 18, which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype. [Differentiation] Abstract

Resveratrol Rescued the TNF-α-Induced Impairments of Osteogenesis of Bone-Marrow Derived Mesenchymal Stem Cells and Inhibited the TNF-α-Activated NF-кB Signaling Pathway
Researchers investigated the effect of resveratrol on osteogenic differentiation of primary mouse bone marrow derived mesenchymal stem cells and potential mechanism involved when cells were exposed to TNF-α treatment. [Int Immunopharmacol] Abstract

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Meniscus Repair Using Mesenchymal Stem Cells – A Comprehensive Review
The purpose of this review is to inform the reader about the current state and advances in meniscus tissue engineering (TE) using mesenchymal stem cells (MSCs). Future directions of MSC-based meniscus TE are also suggested to help guide prospective research. [Stem Cell Res Ther] Full Article

Mesenchymal Stromal Cell Therapy in Hematology: From Laboratory to Clinic and Back Again
The authors review cell therapy applications for mesenchymal stromal cells (MSC) in hematology. In this domain MSC are used for the treatment or prevention of graft versus host disease, support of hematopoiesis or repair of tissue toxicities after hematopoietic cell transplantation. [Stem Cells Dev] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
Anika Therapeutics Announces Presentation of Seven Abstracts
Anika Therapeutics, Inc. announced that seven abstracts related to the Hyalofast product are scheduled for presentation. The research demonstrates that Anika’s hyaluronic acid-based scaffold, Hyalofast, enables patients to naturally regenerate cartilage. [Press release from Anika Therapeutics, Inc. discussing research to be presented at the 12th Annual World Congress of the International Cartilage Repair Society (ICRS), Chicago] Press Release

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Cell Therapy Catapult and Asymptote Collaborate to Revolutionize Delivery of Cell Therapies
The Cell Therapy Catapult and Asymptote are combing forces to advance the development of a novel point-of-care thawing system for cell-based therapies. This device is intended to solve a global barrier to commercialization of cell therapies, by simplifying the delivery of these therapies to patients by addressing significant challenges of delivery at the point-of-care. [Cell Therapy Catapult] Press Release

Green Cross to Build Cell Therapy Manufacturing Facility in China
Green Cross announced plans to build a new cell therapy manufacturing facility at the Guian New Area in the Guizhou province of China. The new manufacturing site sets to address the cellular therapeutic industry’s demand for clinical studies and commercial supply. [Green Cross Corp.] Press Release
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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW ISSCR 2015 Annual Meeting
June 24-27, 2015
Stockholm, Sweden

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Tenure-Track Fellowship – Musculoskeletal Biology (University of Liverpool)

Research Associate – Mesenchymal (STEMCELL Technologies Inc.)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Tenure-Track Faculty Positions – Cellular and Molecular Medicine (University of Ottawa)

Assistant/Associate/Full Professor – Stem Cell Biology & Regenerative Medicine (University of Illinois Chicago College of Medicine)

PhD Position – Biomaterials & Regenerative Medicine (Florida Atlantic University)

Faculty Positions – Stem Cell & Regenerative Medicine (The University of Texas Medical School at Houston)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellowship – Hematology, Immunology, Stem Cell Transplantation, Cancer Therapeutics (The Research Institute at Nationwide Children’s Hospital)

Cell Culture Specialist – Mesenchymal Stem Cell and Neural Stem Cell Cultures (Tisch MS Research Center of New York)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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