Volume 7.19 | May 19

Mesenchymal Cell News 7.19 May 19, 2015
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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Melatonin Reverses H2O2-Induced Premature Senescence in Mesenchymal Stem Cells via the SIRT1-Dependent Pathway
In response to hydrogen peroxide (H2O2) at a sublethal concentration of 200 μM, human bone marrow-derived mesenchymal stem cells underwent growth arrest and cellular senescence. [J Pineal Res] Abstract
Achieve Superior Differentiation of Mouse MSC & MEF into Osteoblasts with the MesenCult™ Osteogenic Stimulatory Kit (Mouse)
PUBLICATIONS (Ranked by impact factor of the journal)
Bone Marrow-Derived Mesenchymal Stem Cells Have Innate Procoagulant Activity and Cause Microvascular Obstruction following Intracoronary Delivery: Amelioration by Anti-Thrombin Therapy
Investigators characterized innate prothrombotic activity of mesenchymal stem cells (MSC) and identified means of its mitigation towards safe and efficacious therapeutic intracoronary MSC delivery post acute myocardial infarction. [Stem Cells] Abstract

Propagation of Pure Fetal and Maternal Mesenchymal Stromal Cells from Terminal Chorionic Villi of Human Term Placenta
Scientists demonstrated the presence of fetal and maternal cells within the tips of terminal chorionic villi of normal human term placenta, and they exploited inherent differences in the adhesive and migratory properties of maternal vs. fetal cells, to establish pure mesenchymal stromal cell cultures of both cell types. [Sci Rep] Full Article

Finding and Tracing Human MSC in 3D Microenvironments with the Photoconvertible Protein Dendra2
A simple and reliable imaging technique was developed to study mesenchymal stem/stromal cell (MSC) dynamical behavior in natural and bioengineered 3D matrices. Human MSC were transfected to express a fluorescent photoswitchable protein, Dendra2, which was used to highlight and follow the same group of cells for more than seven days, even if removed from the microscope to the incubator. [Sci Rep] Full Article

Human Endometrial Mesenchymal Stem Cells Restore Ovarian Function through Improving the Renewal of Germline Stem Cells in a Mouse Model of Premature Ovarian Failure
Mouse ovaries were injured with busulfan and cyclophosphamide to create a damaged ovary mouse model. Transplanted endometrial mesenchymal stem cells were injected into the tail vein of sterilized mice, or culture medium was injected into the sterilized mice via the tail vein as chemoablated group. [J Transl Med]
Abstract | Full Article

Freshly Thawed and Continuously Cultured Human Bone Marrow-Derived Mesenchymal Stromal Cells Comparably Ameliorate Allergic Airways Inflammation in Immunocompetent Mice
Scientists compared freshly thawed versus continuously cultured human bone marrow-derived mesenchymal stromal cell administration in a mouse model of mixed Th2/Th17 allergic airway inflammation induced by Aspergillus hyphal extract exposures in immunocompetent C57Bl/6 mice. [Stem Cells Transl Med] Abstract

Transcriptional Dynamics of Immortalized Human Mesenchymal Stem Cells during Transformation
Scientists performed whole transcriptome analysis to the human mesenchymal stem cell line, UE6E7T-3, which was immortalized with hTERT and human papillomavirus type 16 E6/E7 genes, in association with progress of transformation in these cells. [PLoS One] Full Article

Epigallocatechin-3-Gallate-Induced Free-Radical Production upon Adipogenic Differentiation in Bovine Bone-Marrow Mesenchymal Stem Cells
Investigators explored the variability in free-radical production in bovine bone-marrow mesenchymal stem cells (BMSCs) treated with epigallocatechin-3-gallate (EGCG). Upon adipogenic differentiation, BMSCs were exposed to various EGCG concentrations. [Cell Tissue Res] Abstract

Regulative Effect of mir-205 on Osteogenic Differentiation of Bone Mesenchymal Stem Cells (BMSCs): Possible Role of SATB2/Runx2 and ERK/MAPK Pathway
Researchers investigated the role of mir-205 in the osteogenic differentiation of BMSCs. They found that mir-205 expression was down-regulated in a time-dependent manner during BMSC osteo-induction. [Int J Mol Sci] Abstract | Download Full Article

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Autologous, Allogeneic, Induced Pluripotent Stem Cell or a Combination Stem Cell Therapy? Where Are We Headed in Cartilage Repair and Why: A Concise Review
The authors discuss the different aspects of new stem cell-based treatments, including safety and ethical issues, as well as provide an overview of current clinical trials exploring these approaches and future perspectives. [Stem Cell Res Ther] Full Article

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UB and Roswell Park Receive $1.85 Million Grant to Launch Stem Cell Research Program
University at Buffalo (UB) and Roswell Park Cancer Institute researchers have been awarded a $1.85 million grant to create an interdisciplinary stem cell research training program. The program, called Stem Cells in Regenerative Medicine, will bring together 18 faculty members in UB’s School of Engineering and Applied Sciences and the School of Medicine and Biomedical Sciences, and Roswell Park’s Graduate Division. [University of Buffalo] Press Release

Pluristem’s PLX Cells One Step Closer to Entering Japan’s Accelerated Pathway for Regenerative Medicine
Pluristem Therapeutics Inc. announced that Japan’s Pharmaceuticals and Medical Devices Agency agreed with the proposed quality and large-scale manufacturing methods for PLX-PAD cells for use in clinical trials. [Pluristem Therapeutics Inc.] Press Release

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NEW The 2015 Tissue Engineering Congress
September 8-10, 2015
London, United Kingdom

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NEW Quality Control Scientist (National University of Ireland)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Position – Biomaterials (University of São Paulo)

Tenure-Track Fellowship – Musculoskeletal Biology (University of Liverpool)

PhD Position – Biomaterials & Regenerative Medicine (Florida Atlantic University)

Faculty Positions – Stem Cell & Regenerative Medicine (The University of Texas Medical School at Houston)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellowship – Hematology, Immunology, Stem Cell Transplantation, Cancer Therapeutics (The Research Institute at Nationwide Children’s Hospital)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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