Volume 7.20 | May 26

Mesenchymal Cell News 7.20 May 26, 2015
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
Cell Therapy News on Facebook   MESCN on Twitter
Development of a Gene-Activated Scaffold Platform for Tissue Engineering Applications Using Chitosan-pDNA Nanoparticles on Collagen-Based Scaffolds
Researchers explored the potential of a series of collagen-based scaffolds as gene-activated scaffold platforms with potential in a range of tissue engineering applications. The potential of chitosan, a biocompatible material derived from the shells of crustaceans, as a gene delivery vector was assessed using mesenchymal stem cells. [J Control Release] Abstract
Request Your Free Wallchart: Mesenchymal Stem Cells (A Nature Reviews Molecular Cell Biology Collaboration)
PUBLICATIONS (Ranked by impact factor of the journal)
Activation of NRG1-ERBB4 Signaling Potentiates Mesenchymal Stem Cell-Mediated Myocardial Repairs following Myocardial Infarction
Scientists determined whether overexpression of V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 (ERBB4) in mesenchymal stem cells could enhance their cardio-protective effects following myocardial infarction. [Cell Death Dis] Full Article

miR-148a Is Associated with Obesity and Modulates Adipocyte Differentiation of Mesenchymal Stem Cells through Wnt Signaling
Researchers examined the roles of adipocyte-selective microRNAs (miRNAs) in the differentiation of human adipose-derived mesenchymal stem cells (hMSCs-Ad) to adipocytes. They showed that the levels of miR-148a, miR-26b, miR-30, and miR-199a increased in differentiating hMSCs-Ad. [Sci Rep] Full Article

Influence of Erythropoietin on Microvesicles Derived from Mesenchymal Stem Cells Protecting Renal Function of Chronic Kidney Disease
Investigators studied the influence of erythropoietin on microvesicles derived from mesenchymal stem cells, and the protective effects of these factors in subjects with chronic kidney disease [Stem Cell Res Ther] Abstract | Full Article

Mesenchymal Stem Cells Derived from Peripheral Blood Retain their Pluripotency but Undergo Senescence during Long-Term Culture
The authors triggered production of peripheral blood-derived mesenchymal stem cells (PB-MSCs) in rabbits using G-CSF and AMD3100, and then isolated and expanded the cells in culture until they reached a state of senescence, usually after about 20 passages. [Tissue Eng Part C Methods] Abstract

Isolation and Characterization of Mesenchymal Stem/Stromal Cells in the Ovine Endometrium
In preparation for developing a large animal preclinical model for urological and gynecological tissue engineering applications researchers aimed to identify and characterize mesenchymal stem/stromal cells in ovine endometrium and determine surface markers to enable their prospective isolation. [PLoS One] Full Article

Capsaicin Inhibits the Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by Regulating Cell Proliferation, Apoptosis, Oxidative and Nitrosative Stress
Scientists analyzed whether capsaicin is capable of inhibiting the differentiation of bone marrow mesenchymal stem cells (BMSCs) to adipocytes. BMSCs were obtained and exposed to different concentrations of capsaicin for a period of six days following two days of adipogenic induction. [Food Funct] Abstract

Human Mesenchymal Stem Cells Enhance Cancer Cell Proliferation via IL-6 Secretion and Activation of ERK1/2
Researchers evaluated the effects of human mesenchymal stem cells (hMSC) on head and neck squamous cell carcinoma cell lines (FaDu and HLaC78) in vitro. hMSC released several cytokines and growth factors. FaDu and HLaC78 showed a significant enhancement of cell proliferation after cultivation with hMSC-conditioned medium as compared to control. [Int J Oncol] Abstract

Apigenin Promotes Osteogenic Differentiation of Human Mesenchymal Stem Cells through JNK and p38 MAPK Pathways
The effect of apigenin on osteogenic differentiation of human mesenchymal stem cells (hMSCs) was explored. Scientists showed that apigenin treatment significantly increased alkaline phosphatase activity and mineralization in hMSCs. [Mol Cell Biochem] Abstract

Enhancement of Human Mesenchymal Stem Cell Infiltration into the Electrospun Poly(Lactic-co-Glycolic Acid) Scaffold by Fluid Shear Stress
Scientists investigated the directional migration of human mesenchymal stem cells and infiltration into poly(lactic-co-glycolic acid) scaffold by fluid shear stress. The human mesenchymal stem cells showed directional migrations following the direction of the flow. [Biochem Biophys Res Commun] Abstract

Learn More: Standardized Tools for Cancer Research
Stem and Progenitor Cells: Advancing Bone Tissue Engineering
Researchers introduce various adult stem cells implemented in bone tissue engineering such as mesenchymal stem cells (including bone marrow- and adipose-derived stem cells), endothelial progenitor cells, and induced pluripotent stem cells. [Drug Deliv Transl Res] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
Cynata Announces Progress on Cymerus™ Mesenchymal Stem Cell Product Development Activities
Cynata Therapeutics Ltd. provided a progress report on the development of its lead Cymerus™ mesenchymal stem cell product, CYP-001. [Cynata Therapeutics Ltd.] Press Release

Cancer Prevention and Research Institute of Texas Awards 41 New Grants
The Cancer Prevention and Research Institute of Texas awarded 28 grants through its academic research program, 11 grants through its prevention program and two grants through its product development research program. [Cancer Prevention and Research Institute of Texas] Press Release

From our sponsor:
Optimize your ALDHbr cell detection with tissue-specific ALDEFLUOR™ protocols.
Watch the video.
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Nordic Life Sciences Days 2015
September 9-10, 2015
Stockholm, Sweden

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Assistant/Associate/Full Professor – Stem Cells (Shanghai Jiao Tong University)

NEW Postdoctoral Fellow – Stem Cell Biology and Pharmacogenomics (Northwestern University)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Quality Control Scientist (National University of Ireland)

Postdoctoral Position – Biomaterials (University of São Paulo)

Faculty Positions – Stem Cell & Regenerative Medicine (The University of Texas Medical School at Houston)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellowship – Hematology, Immunology, Stem Cell Transplantation, Cancer Therapeutics (The Research Institute at Nationwide Children’s Hospital)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

Recruit Top Talent: Reach more than 60,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Mesenchymal Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here
Learn more about Mesenchymal Cell News: Archives | Events | Contact Us