Volume 7.21 | Jun 2

Mesenchymal Cell News 7.21 June 2, 2015
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
The Microwell-Mesh: A Novel Device and Protocol for the High Throughput Manufacturing of Cartilage Microtissues
The authors describe the first microwell platform that incorporates a mesh to retain microtissues within discrete microwells; the microwell-mesh. They used the microwell-mesh to manufacture hundreds of cartilage microtissues, each formed from 5×103 bone marrow-derived mesenchymal stem/stromal cells. [Biomaterials] Full Article
Going to ISSCR 2015? We’ll see you there!
 
PUBLICATIONS (Ranked by impact factor of the journal)
Fluocinolone Acetonide Is a Potent Synergistic Factor of TGF-β3-Associated Chondrogenesis of Bone Marrow-Derived Mesenchymal Stem Cells for Articular Surface Regeneration
Chemical inhibition of mTORC1 with rapamycin substantially suppressed fluocinolone acetonide effect, and inhibition of AKT completely repressed chondrogenesis of human bone marrow-derived mesenchymal stem cells. [J Bone Miner Res] Abstract

Combinatorial Effect of Substratum Properties on Mesenchymal Stem Cell Sheet Engineering and Subsequent Multi-Lineage Differentiation
Polydimethylsiloxane of different combinatorial substratum properties were created, on which human bone marrow derived mesenchymal stem cells were cultured to form cell sheets with their multipotency evaluated after induced differentiation. [Acta Biomater] Abstract

Protein Kinase CK2 Is Necessary for the Adipogenic Differentiation of Human Mesenchymal Stem Cells
The authors analyzed CK2 during adipogenic differentiation of human mesenchymal stem cells. With progress of the differentiation CK2 protein level and the kinase activity decreased. [Biochim Biophys Acta] Abstract

Paracrine Effects of Hematopoietic Cells on Human Mesenchymal Stem Cells
Scientists assessed the paracrine effects of extrinsic factors from hematopoietic cells on human mesenchymal stem cells (MSCs). They showed that hematopoietic cells stimulate proliferation, osteoblast differentiation and inhibit senescence of MSCs. [Sci Rep] Full Article

High-Throughput Screening of Surface Marker Expression on Undifferentiated and Differentiated Human Adipose-Derived Stromal Cells
By comprehensively characterizing the surface marker profile of undifferentiated human adipose-derived stromal cells (hASCs) using flow cytometry, researchers gained novel insight into the heterogeneity underlying protein expression on the surface of cultured undifferentiated hASCs across different donors. [Tissue Eng Part A] Abstract

Yes-Associated Protein (YAP) Is a Negative Regulator of Chondrogenesis in Mesenchymal Stem Cells
Scientists investigated whether the transcriptional co-factor YAP regulates chondrogenic differentiation of mesenchymal stromal/stem cells (MSCs). YAP, but not transcriptional co-activator with PDZ-binding motif, was downregulated during in vitro chondrogenesis of human MSCs. [Arthritis Res Ther] Full Article

Effect of TGF-β1 Stimulation on the Secretome of Human Adipose-Derived Mesenchymal Stromal Cells
Transforming growth factor-β1 (TGF-β1) expression increases in various tissues with damage, especially when accompanied by inflammation. Thus, researchers analyzed the effect of TGF-β1 on the secretion by adipose-derived mesenchymal stromal cells of a panel of 80 cytokines/chemokines using an antibody array. [Stem Cells Transl Med] Abstract

Comparative Analysis of Neural Differentiation Potential in Human Mesenchymal Stem Cells Derived from Chorion and Adult Bone Marrow
Investigators isolated and cultured chorion mesenchymal stem cells (C-MSCs) and compared their proliferative capacity, multipotency, and neural differentiation ability with bone marrow (BM)-MSCs. C-MSCs showed a higher proliferative capacity compared with BM-MSCs. [Cell Tissue Res] Abstract

Clinically Applicable Human Adipose Tissue-Derived Mesenchymal Stem Cells Delivering Therapeutic Genes to Brainstem Gliomas
In a good manufacturing practice facility, researchers established clinically applicable human adipose-derived mesenchymal stem cells expressing therapeutic genes and investigated their therapeutic efficacy against brainstem glioma in mice. [Cancer Gene Ther] Abstract

Human Adipose-Derived Mesenchymal Progenitor Cells Engraft into Rabbit Articular Cartilage
Scientists investigated whether intra-articular injection of xenogeneic human adipose-derived mesenchymal progenitor cells promoted articular cartilage repair in rabbit osteoarthritis model and engrafted into rabbit articular cartilage. [Int J Mol Sci] Abstract | Download Full Article

Expression of α-Smooth Muscle Actin Determines the Fate of Mesenchymal Stromal Cells
Researchers investigated whether incorporation of α-smooth muscle actin (α-SMA) into contractile stress fibers regulates human mesenchymal stromal cell (MSC) fate. Sorted α-SMA-positive MSCs exhibited high contractile activity, low clonogenicity, and differentiation potential limited to osteogenesis. [Stem Cell Rep]
Full Article | Graphical Abstract

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REVIEWS
Bone Marrow Mesenchymal Stem Cell Therapy for Voiding Dysfunction
The authors critically review the literature regarding the use of bone marrow mesenchymal stem cells in treatment of voiding dysfunction. [Curr Urol Rep] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
 
INDUSTRY NEWS
Sistemic and RoosterBio Inc. Announce Broad Collaboration Agreement to Advance miRNA and Mesenchymal Stem/Stromal Cell (MSC) Regenerative Technology
RoosterBio and Sistemic will collaborate on utilizing microRNA (miRNA)-based cell characterization workflows and technologies to build more precise and relevant characterization panels for human MSC products and in process cell banks. [Sistemic Scotland Limited] Press Release

OrthoTrophix Completed Subject Enrollment of the Phase II Clinical Trial of a New Cartilage Repair Therapeutic for Knee Osteoarthritis
OrthoTrophix, Inc. announced that the company completed subject enrollment and all scheduled dosing in its Phase II clinical study of TPX-100 in subjects with bilateral osteoarthritis of the knee. [OrthoTrophix, Inc.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Stem Cell Society Singapore (SCSS) 2015
November 17-18, 2015
Singapore, Singapore

Visit our events page to see a complete list of events in the mesenchymal cell community.
 
JOB OPPORTUNITIES
NEW PhD Positions – Cartilage Regeneration in Joints and Intervertebral Disc Diseases (Cardiff University)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Assistant/Associate/Full Professor – Stem Cells (Shanghai Jiao Tong University)

Postdoctoral Fellow – Stem Cell Biology and Pharmacogenomics (Northwestern University)

Postdoctoral Position – Biomaterials (University of São Paulo)

Faculty Positions – Stem Cell & Regenerative Medicine (The University of Texas Medical School at Houston)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellowship – Hematology, Immunology, Stem Cell Transplantation, Cancer Therapeutics (The Research Institute at Nationwide Children’s Hospital)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)


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