Volume 7.23 | Jun 16

Mesenchymal Cell News 7.23 June 16, 2015
Mesenchymal Cell News
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Scientists Identify a Potential New Treatment for Osteoporosis
Scientists have identified a new therapeutic approach that, while still preliminary, could promote the development of new bone-forming cells in patients suffering from bone loss. [Press release from The Scripps Research Institute discussing online prepublication in Nature Communications] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Oncogenic Transformation Can Orchestrate Immune Evasion and Inflammation in Human Mesenchymal Stem Cells Independently of Extrinsic Immune-Selective Pressure
Neoplastic transformation increased the natural immune evasive properties of human mesenchymal stem cells (hMSC), both by reducing their immunogenicity and by increasing their capacity to inhibit mitogen driven T-cell proliferation. Researchers also found that IFN-γ signaling was globally affected in transformed hMSC. [Cancer Res] Abstract

Simple Coating with Fibronectin Fragment Enhances Stainless Steel Screw Osseointegration in Healthy and Osteoporotic Rats
The authors present a simple coating strategy based on passive adsorption of FN7-10, a recombinant fragment of human fibronectin encompassing the major cell adhesive, integrin-binding site, onto 316-grade stainless steel (SS). FN7-10 coating on SS surfaces promoted α5β1 integrin-dependent adhesion and osteogenic differentiation of human mesenchymal stem cells. [Biomaterials] Abstract

SWI/SNF-Mediated Lineage Determination in Mesenchymal Stem Cells Confers Resistance to Osteoporosis
BRM is not required for development, which has hindered understanding of its contributions, but knockdown genetics, designed to explore the hypothesis that BRM-SWI/SNF has different regulatory roles in different mesenchymal stem cell lineages, showed that depleting BRM from mesenchymal stem cells has a dramatic effect on the balance of lineage selection between osteoblasts and adipocytes. [Stem Cells] Abstract

A Method for Performing Islet Transplantation Using Tissue-Engineered Sheets of Islets and Mesenchymal Stem Cells
Investigators describe a tissue engineering approach using islets with mesenchymal stem cell sheets to improve the therapeutic effect of islet transplantation. [Tissue Eng Part C Methods] Abstract

Gata4, Tbx5 and Baf60c Induce Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells into Beating Cardiomyocytes
Scientists showed that the combination of Gata4, Tbx5 and Baf60c is sufficient for inducing adipose tissue-derived mesenchymal stem cells to form cardiomyocytes. It also appears that, while Gata4 and Baf60c are key inducers of myocardial differentiation, Tbx5 is essential for the ability of cardiac cells to contract. [Int J Biochem Cell Biol] Abstract

Human Adipose Tissue-Derived Mesenchymal Stem Cells Target Brain Tumor-Initiating Cells
Both in vitro and in vivo experiments showed that human adipose tissue derived mesenchymal stem cells possess migratory abilities to target brain tumor-initiating cells isolated from medulloblastoma, atypical teratoid/rhabdoid tumors and glioblastoma. [PLoS One] Full Article

Connexin43 Mediated Delivery of ADAMTS5 Targeting siRNAs from Mesenchymal Stem Cells to Synovial Fibroblasts
Researchers transduced human mesenchymal stem cells (hMSCs) with ADAMTS5-targeting shRNA or non-targeted shRNA, and co-cultured them with synovial fibroblasts to allow delivery of siRNAs from hMSC to synovial fibroblasts. They found that co-culture of hMSCs-shRNA-ADAMTS5 and synovial fibroblasts reduced ADAMTS5 expression relative to co-culture of hMSCs-shRNA-control and synovial fibroblasts. [PLoS One] Full Article

Effect of Bioactive Glass Particles on Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells Seeded on Lactide and Caprolactone Based Scaffolds
In this study the influence of incorporating bioactive glass particles to lactide and caprolactone based porous scaffolds on osteogenic differentiation of adipose-derived stem cells was analyzed. [J Biomed Mater Res A] Abstract

Multiparameter Analysis of Human Bone Marrow Stromal Cells Identifies Distinct Immunomodulatory and Differentiation-Competent Subtypes
Scientists used immortalized human bone marrow stromal cells (BMSC) clonal lines for multi-level analysis of functional markers for BMSC subsets. All clones expressed typical BMSC cell-surface antigens; however, clones with trilineage differentiation capacity exhibited enhanced vascular interaction gene sets, whereas non-differentiating clones were uniquely CD317 positive with significantly enriched immunomodulatory transcriptional networks and high IL-7 production. [Stem Cell Rep] Full Article | Press Release

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Mesenchymal Stem Cells Therapy for Autoimmune Disease: Risks and Rewards
The authors analyze the current data from early phase trials into Crohn’s disease, systemic lupus erythematosus, and rheumatoid arthritis. In general, no adverse side-effects were observed in patients treated with mesenchymal stem cells; however, their clinical efficacy is difficult to interpret. [Stem Cells Dev] Abstract

Mesenchymal Stem Cells and Adaptive Immune Responses
The authors review the influence of mesenchymal stem cells (MSCs) on adaptive immune system, especially their bidirectional interaction in tuning the immune microenvironment and subsequently repairing damaged tissue. Understanding MSC-mediated regulation of T cells is expected to provide fundamental information for guiding appropriate applications of MSCs in clinical settings. [Immunol Lett] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
STEMCELL Technologies Named Company of the Year by BIOTECanada
STEMCELL Technologies Inc. will be presented with the Biotech Company of the Year award by BIOTECanada at this year’s BIO International Convention in Philadelphia. [BIOTECanada] Press Release

Cord Blood Registry’s New Disease Registry Brings Data & Families Together to Advance Stem Cell Research
Cord Blood Registry® announced the launch of CBR’s Family Health Registry, a unique registry designed to offer insight into common diseases and conditions affecting families and to bring patients, healthcare professionals and researchers together to expedite and facilitate research related to the discovery of stem cell treatments and potential cures. [Cord Blood Registry®] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Cell Symposia Meeting – Stem Cell Epigenetics
September 20-22, 2015
Sitges, Spain

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Postdoctoral Fellow – Stem Cell Biology (INSERM)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Research Scientist – Stem Cell Biology (ODU Research Foundation)

Postdoctoral Fellowship – Molecular Biology and Epigenetics (Rutgers New Jersey Medical School)

PhD Positions – Cartilage Regeneration in Joints and Intervertebral Disc Diseases (Cardiff University)

Assistant/Associate/Full Professor – Stem Cells (Shanghai Jiao Tong University)

Postdoctoral Fellow – Stem Cell Biology and Pharmacogenomics (Northwestern University)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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