Volume 7.24 | Jun 23

Mesenchymal Cell News 7.24 June 23, 2015
Mesenchymal Cell News
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Tissue ‘Scaffold’ Technology Could Help Rebuild Large Organs
Scientists have developed a new tissue ‘scaffold’ technology that could one day enable the engineering of large organs. They have shown that it is possible to combine cells with a special scaffold to produce living tissue in the laboratory. [Press release from the University of Liverpool discussing online prepublication in Nature Communications] Press Release | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
miR-21 Modulates the Immunoregulatory Function of Bone Marrow Mesenchymal Stem Cells through the PTEN/Akt/TGF-β1 Pathway
The authors showed that microRNA (miR)-21 negatively regulates the activity of immunoregulatory cytokine TGF-β1 in mesenchymal stem cells (MSCs). Consistently, bone marrow MSCs (BMMSCs) from miR-21-/- mice showed enhanced immunosuppressive function by more TGF-β1 secretion and induce more CD4+Foxp3+ regulatory T cells compared to wild-type BMMSCs in vitro, which anti-TGF-β1 antibody abrogates. [Stem Cells] Abstract

Neuroprotective Effect of Human Mesenchymal Stem Cells in a Compartmentalized Neuronal Membrane System
Investigators describe the development of a compartmentalized membrane system using neonatal rodent hippocampal cells and human mesenchymal stem cells (hMSCs) to investigate the neuroprotective effects of hMSCs. [Acta Biomater] Abstract

Isolation and Characterization of Human Mesenchymal Stromal Cells Subpopulations: Comparison of Bone Marrow and Adipose Tissue
Researchers performed immunomagnetic selections with five single surface markers to isolate mesenchymal stromal cell subpopulations from bone marrow and adipose tissue: CD271, SUSD2, MSCA-1, CD44 and CD34. They determined the phenotype, the clonogenicity, the proliferation, the differentiation capacity and the immunoregulatory profile of the sub-populations obtained in comparison with unselected cells. [Stem Cells Dev] Abstract

Cytoskeletal to Nuclear Strain Transfer Regulates YAP Signaling in Mesenchymal Stem Cells
Scientists report that actomyosin-generated cytoskeletal tension regulates nuclear shape and force transmission through the cytoskeleton and demonstrate the differential short- and long-term response of mesenchymal stem cells to dynamic tensile loading based on the contractility state, the patency of the actin cytoskeleton, and the connections it makes with the nucleus. [Biophys J] Abstract

Effects of Transplantation of CTLA4Ig-Overexpressing Adipose Tissue-Derived Mesenchymal Stem Cells in Mice with Sustained Severe Rheumatoid Arthritis
Investigators aimed to determine whether CTLA4Ig and human adipose tissue-derived mesenchymal stem cells showed synergistic effects on immunomodulation and clinical improvement of sustained severe rheumatoid arthritis in a mouse model. [Cell Transplant] Full Article

Low Extracellular Sodium Promotes Adipogenic Commitment of Human Mesenchymal Stromal Cells: A Novel Mechanism for Chronic Hyponatremia-Induced Bone Loss
The authors investigated the effects of a chronic reduction of extracellular sodium concentrations, independently of osmotic stress, on human mesenchymal stromal cells from bone marrow, the common progenitor for osteoblasts and adipocytes. [Endocrine] Abstract

Isolation, Culture, Differentiation, and Nuclear Reprogramming of Mongolian Sheep Fetal Bone Marrow-Derived Mesenchymal Stem Cells
Scientists characterized the differentiation potentiality and the developmental potential of cloned embryos of fetal bone marrow mesenchymal stem cells isolated from Mongolian sheep. [Cell Reprogram] Abstract

Regulation of Human Mesenchymal Stem Cell Differentiation by TREM-2
Scientists demonstrated that triggering receptor expressed on myeloid cells 2 (TREM-2) is expressed by human mesenchymal stem cells and responds to the toll-like receptor ligand lipopolysaccharide. [Hum Immunol] Abstract

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The Secretome of Mesenchymal Stromal Cells: Role of Extracellular Vesicles in Immunomodulation
The authors focus their attention on the extracellular vesicles as paracrine mediators of mesenchymal stromal cell immune-modulation. [Immunol Lett] Abstract

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A Better Way to Build Bones
A team of researchers at the New York University Polytechnic School of Engineering, NYU School of Medicine, and Stanford University School of Medicine has received a $1.1 million grant from the U.S. Veterans Health Administration’s Office of Rehabilitation Research and Development to pioneer a novel approach to harnessing the body’s own chemical signals to speed bone regeneration and improve repair. [NYU School of Engineering] Press Release

PrimeGen Biotech Reaffirms Its Commitment to Stem Cell Science – Opens New 10,000 Square Foot Research Facility and HQ
PrimeGen Biotech announced the opening of its new 10,000 square-foot research facility located in Santa Ana, California. PrimeGen’s new facility was designed to give its research team the space and tools necessary to delve deeper into the characterization of stem cells and their respective therapeutic value, while complying with FDA’s Current Good Manufacturing Practice regulations. [PrimeGen Biotech LLC (PR Newswire Association LLC)] Press Release

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NEW 3rd International Annual Conference of the German Stem Cell Network (GSCN)
September 9-11, 2015
Frankfurt, Germany

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NEW Postdoctoral Position – Bioengineering (University of California, San Diego)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Stem Cell Biology (INSERM)

Research Scientist – Stem Cell Biology (ODU Research Foundation)

Postdoctoral Fellowship – Molecular Biology and Epigenetics (Rutgers New Jersey Medical School)

PhD Positions – Cartilage Regeneration in Joints and Intervertebral Disc Diseases (Cardiff University)

Assistant/Associate/Full Professor – Stem Cells (Shanghai Jiao Tong University)

Postdoctoral Fellow – Stem Cell Biology and Pharmacogenomics (Northwestern University)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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