Volume 7.26 | Jul 7

Mesenchymal Cell News 7.26 July 7, 2015
Mesenchymal Cell News
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Interleukin-17A-Induced Human Mesenchymal Stem Cells Are Superior Modulators of Immunological Function
The authors present an improved approach where they modified human bone marrow-derived mesenchymal stem cells with interleukin-17A to enhance T cell immunosuppression but not their immunogenicity. [Stem Cells] Abstract | Press Release
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PUBLICATIONS (Ranked by impact factor of the journal)
Mesenchymal Stem Cells Do Not Exert Direct Beneficial Effects on CNS Remyelination in the Absence of the Peripheral Immune System
The authors determined potential regenerative functions of mesenchymal stem cells in the toxic cuprizone model of demyelination that allows studying direct effects on de- and remyelination without the influence of the peripheral immune system. [Brain Behav Immun] Abstract

BMP-2 Derived Peptide and Dexamethasone Incorporated Mesoporous Silica Nanoparticles for Enhanced Osteogenic Differentiation of Bone Mesenchymal Stem Cells
Bone morphogenetic protein-2 (BMP-2) peptide functionalized mesoporous silica nanoparticles (MSNs-pep) were synthesized by covalently grafting BMP-2 peptide on the surface of nanoparticles via an aminosilane linker, and dexamethasone was then loaded into the channel of MSNs to construct nanoparticulate osteogenic delivery systems. [ACS Appl Mater Interfaces] Abstract

Human Bone Marrow- and Adipose-Mesenchymal Stem Cells Secrete Exosomes Enriched in Distinctive miRNA and tRNA Species
Researchers characterized the full small RNAome of mesenchymal stem cell (MSC)-produced exosomes. They set up a protocol for isolating exosomes released by early passage adipose- and bone marrow-MSCs and characterized them via electron microscopy, protein analysis and small RNA-sequencing. [Stem Cell Res Ther] Abstract | Full Article

EphB4 Promotes Osteogenesis of CTLA4 Modified Bone Marrow Derived Mesenchymal Stem Cells through Cross-Talk with Wnt Pathway in Xenotransplantation
Cytotoxic T lymphocyte-associated antigen 4-Ig modified bone marrow derived mesenchymal stem cells (MSCs-CTLA4) were investigated for their osteogenic capacity via xenotransplantation in vivo. MSCs-CTLA4 were treated with ephrinB2-FC or FC under conditions of osteogenic induction and cultured with or without immune activation conditions established by PHA and PBMCs in vitro. [Tissue Eng Part A] Abstract

A Xeno-Free Microcarrier-Based Stirred Culture System for the Scalable Expansion of Human Mesenchymal Stem/Stromal Cells Isolated from Bone Marrow and Adipose Tissue
Scientists optimized a previously developed xeno-free microcarrier-based system for the scalable expansion of human mesenchymal stem/stromal cells isolated from bone marrow and adipose-derived stem/stromal cells. [Biotechnol J] Abstract

Multi-Layered Scaffolds for Osteochondral Tissue Engineering: In Vitro Response of Co-Cultured Human Mesenchymal Stem Cells
Investigators developed multi-layered scaffolds by assembling a gelatin layer with layers containing different amounts of gelatin and hydroxyapatite nanocrystals, and using a gelatin solution (as a glue) to stick layers together. In vitro tests demonstrated that the different layers of the scaffolds promote chondrogenic and osteogenic differentiation of human mesenchimal stem cells. [Macromol Biosci] Abstract

Viability and MR Detectability of Iron Labeled Mesenchymal Stem Cells Used for Endoscopic Injection into the Porcine Urethral Sphincter
The authors evaluated proliferation, migration, differentiation and adhesion effects as well as the obtained iron load of an iron labeling strategy for mesenchymal stem cells. [NMR Biomed] Abstract

Suppression of Ornithine Decarboxylase Promotes Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells
Suppression of ornithine decarboxylase by its irreversible inhibitor, α-difluoromethylornithine, or by RNA interference through siRNA, enhanced osteogenic gene expression and alkaline phosphatase activity, and accelerated matrix mineralization of human bone marrow-derived mesenchymal stem cells. [FEBS Lett] Abstract

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Genetic Engineering of Mesenchymal Stem Cells for Regenerative Medicine
In this review, the latest applications of genetic engineering methods for mesenchymal stem cells with regenerative medicine purposes are presented. [Stem Cells Dev] Abstract

Therapeutic Potential of Differentiated Mesenchymal Stem Cells for Treatment of Osteoarthritis
The authors provide insight into possible strategies for cartilage regeneration by transplantation of differentiated mesenchymal stem cells to treat osteoarthritis patients. [Int J Mol Sci] Abstract | Download Full Article

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AMAG Pharmaceuticals to Acquire Cord Blood Registry
AMAG Pharmaceuticals, Inc. announced that it has entered into a definitive agreement to acquire Cord Blood Registry®, the world’s largest stem cell collection and storage company serving pregnant women and their families, for $700 million. [Cord Blood Registry®] Press Release

R-Japan Obtained Autologous Stem Cell Manufacturing License from the Ministry of Health, Labor and Welfare
R-Japan Co., Ltd. obtained the license of cell processing facility under the Act on the Safety of Regenerative Medicine from the Ministry of Health, Labor and Welfare Kinki Bureau of Health and Welfare. [R-Japan Co., Ltd. (PR Newswire Association LLC)] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Cold Spring Harbor Stem Cell Biology Meeting
October 7-11, 2015
Cold Spring Harbor, United States

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NEW Researcher – Stem Cell Research (Helse Bergen – Haukeland University Hospital)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientific Writer – Stem Cells and Regenerative Medicine (University of Washington)

Postdoctoral Position – Bioengineering (University of California, San Diego)

Postdoctoral Fellow – Stem Cell Biology (INSERM)

Research Scientist – Stem Cell Biology (ODU Research Foundation)

Postdoctoral Fellowship – Molecular Biology and Epigenetics (Rutgers New Jersey Medical School)

Assistant/Associate/Full Professor – Stem Cells (Shanghai Jiao Tong University)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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