Volume 7.27 | Jul 14

Mesenchymal Cell News 7.27 July 14, 2015
Mesenchymal Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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A Phase II Dose-Escalation Study of Allogeneic Mesenchymal Precursor Cells in Patients with Ischemic or Non-Ischemic Heart Failure
Investigators evaluated the feasibility and safety of three doses (25, 75, or 150 million cells) of immunoselected allogeneic mesenchymal precursor cells in chronic heart failure patients in a Phase II trial. [Circ Res] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Genome-Wide MicroRNA and Gene Analysis of Mesenchymal Stem Cell Chondrogenesis Identifies an Essential Role and Multiple Targets for miR-140-5p
Using microarray analysis of microRNA (miRNA) expression during mesenchymal stem cell chondrogenic differentiation and detailed examination of the role of essential differentiation factors, such as SOX9, TGF-β and the cell condensation phase, scientists characterized the repertoire of specific miRNAs involved in chondrocyte development, highlighting in particular miR-140 and miR-455. [Stem Cells] Abstract

A Role for MOSPD1 in Mesenchymal Stem Cell Proliferation and Differentiation
Researchers generated MOSPD1-null embryonic stem cells and demonstrated that they are deficient in their ability to differentiate into a number of cell lineages including osteoblasts, adipocytes and hematopoietic progenitors. [Stem Cells] Abstract

Rapid Fusion between Mesenchymal Stem Cells and Cardiomyocytes Yields Electrically Active, Non-Contractile Hybrid Cells
Researchers investigated direct interactions between human mesenchymal stem cells (hMSCs) and cardiomyocytes in vitro. Using a genetic Ca2+ indicator gCaMP3 to efficiently label hMSCs in co-cultures with neonatal rat ventricular myocytes (NRVMs), they determined that 25–40% of hMSCs acquired periodic Ca2+ transients and cardiac markers through spontaneous fusion with NRVMs. [Sci Rep] Full Article

Electrical Stimulation of Human Mesenchymal Stem Cells on Conductive Nanofibers Enhances Their Differentiation toward Osteogenic Outcomes
Investigators describe the preparation of conductive fiber-based bone tissue scaffolds that enable the electrical stimulation of human mesenchymal stem cells to enhance their differentiation toward osteogenic outcomes. [Macromol Rapid Commun] Abstract

MicroRNA-103a-3p Controls Proliferation and Osteogenic Differentiation of Human Adipose Tissue-Derived Stromal Cells
To examine the role of the microRNA-103a-3p (miR-103a-3p) in human adipose tissue-derived stromal cells (hADSCs) functions, miR-103a-3p mimics were transfected into hADSCs in order to overexpress miR-103a-3p. Overexpression of miR-103a-3p inhibited the proliferation and osteogenic differentiation of hADSCs. [Exp Mol Med] Full Article

Biological Behavior of Mesenchymal Stem Cells on Poly-ε-Caprolactone Filaments and a Strategy for Tissue Engineering of Segments of the Peripheral Nerves
Scientists describe the interaction between poly-caprolactone (PCL) filaments and mesenchymal stem cells (MSC), aiming to optimize peripheral nervous system tubular implants. MSC were plated on PCL filaments for 48 hours and the adhesion profile, viability, proliferation and paracrine capacity were evaluated. [Stem Cell Res Ther] Abstract | Full Article

Useful Properties of Undifferentiated Mesenchymal Stromal Cells and Adipose Tissue as the Source in Liver-Regenerative Therapy Studied in an Animal Model of Severe Acute Fulminant Hepatitis
Researchers analyzed whether undifferentiated mesenchymal stromal cells (MSCs) or MSC-derived hepatocyte-like cells from adipose tissue, umbilical cord blood and bone marrow would better restore damaged liver. [Cytotherapy] Abstract

MicroRNA-153 Suppresses the Osteogenic Differentiation of Human Mesenchymal Stem Cells by Targeting Bone Morphogenetic Protein Receptor Type II
Scientists examined the role of microRNA (miR)-153 in the osteogenesis of human mesenchymal stem cells and investigated the impact of miR-153 on bone morphogenetic protein receptor type II expression. [Int J Mol Med] Abstract

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Mesenchymal Stromal Cells and Rheumatic Disorders
Mesenchymal stromal cells have been the intense focus of in vitro studies and animal models of rheumatic and other diseases over more than a decade. Despite multiple plausible mechanisms of action and a plethora of positive in vivo animal studies, few randomized controlled clinical trials have demonstrated meaningful clinical benefit in any condition so far. [Immunol Lett] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Stem Cells & Regenerative Medicine Congress 2015
Ocata Therapeutics Announces New Pre-Clinical Data to Be Reported
Ocata Therapeutics, Inc. announced that data demonstrated potential therapeutic activity of a pluripotent stem cell-derived product for the treatment of autoimmune diseases such as lupus nephritis and Crohn’s disease using Ocata’s proprietary hemangio-derived mesenchymal cell platform. [Press release from Ocata Therapeutics, Inc. discussing research to be presented at the 11th International Congress on Systemic Lupus Erythematosus, Vienna] Press Release

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The Paul G. Allen Family Foundation Partners with the Alzheimer’s Association to Award Grants for Foundational Alzheimer’s Research
The Paul G. Allen Family Foundation and the Alzheimer’s Association announced the award of three grants at the frontier of investigating the role of the immune system in Alzheimer’s disease. [The Paul G. Allen Foundation] Press Release

Groundbreaking Clinical Trial to Assess Use of Newborn Stem Cells in the Treatment of Pediatric Stroke
Cord Blood Registry® announced the launch of an FDA-regulated clinical trial to investigate autologous stem cell therapy in children diagnosed as having had a prenatal or perinatal pediatric stroke. [Cord Blood Registry®] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Stem Cell Meeting on the Mesa
October 7-9, 2015
La Jolla, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Postdoctoral Research Fellow – Fat Metabolism and Stem Cells (Singapore Bioimaging Consortium)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Researcher – Stem Cell Research (Helse Bergen – Haukeland University Hospital)

Scientific Writer – Stem Cells and Regenerative Medicine (University of Washington)

Postdoctoral Fellow – Stem Cell Biology (INSERM)

Research Scientist – Stem Cell Biology (ODU Research Foundation)

Postdoctoral Fellowship – Molecular Biology and Epigenetics (Rutgers New Jersey Medical School)

Assistant/Associate/Full Professor – Stem Cells (Shanghai Jiao Tong University)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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