Volume 7.28 | Jul 21

Mesenchymal Cell News 7.28 July 21, 2015
Mesenchymal Cell News
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Fractal Heterogeneity in Minimal Matrix Models of Scars Modulates Stiff-Niche Stem-Cell Responses via Nuclear Exit of a Mechanorepressor
Researchers showed that copolymerization of collagen I with polyacrylamide produces minimal matrix models of scars (MMMS), in which fractal-fibre bundles segregate heterogeneously to the hydrogel subsurface. The MMMS elicits scar-like phenotypes from mesenchymal stem cells: cells spread and polarize quickly, increasing nucleoskeletal lamin-A yet expressing the ‘scar marker’ smooth muscle actin more slowly. [Nat Mater]
Abstract | Press Release
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PUBLICATIONS (Ranked by impact factor of the journal)
Mesenchymal Stromal Cells Prevent Allostimulation In Vivo and Control Checkpoints of Th1 Priming: Migration of Human DC to Lymph Nodes and NK Cell Activation
Researchers investigated the impact of mesenchymal stromal cells on the functionality of human myeloid dendritic cells and the consequences for natural killer (NK) cell and Type 1 helper (Th1) priming in vitro and in vivo. [Stem Cells] Abstract

A Comparative Study of the Therapeutic Potential of Mesenchymal Stem Cells and Limbal Epithelial Stem Cells for Ocular Surface Reconstruction
Investigators prepared mesenchymal stromal/stem cells from bone marrow or adipose tissue as well as limbal epithelial stem cells, and their growth, differentiation, and secretory properties were compared. [Stem Cells Transl Med] Abstract

Modulation of Chondrogenic Differentiation of Human Mesenchymal Stem Cells in Jellyfish Collagen Scaffolds by Cell Density and Culture Medium
Researchers applied porous scaffolds made of collagen from the jellyfish Rhopilema esculentum for the in vitro chondrogenic differentiation of human mesenchymal stem cells (hMSCs). They systematically investigated the influence of seeding density, basic culture media with varying glucose content and supplementation with fetal calf serum or bovine serum albumin on the chondrogenic differentiation of hMSCs. [J Tissue Eng Regen Med] Abstract

Direct Cell-Cell Contact with Chondrocytes Is a Key Mechanism in Multipotent Mesenchymal Stromal Cell-Mediated Chondrogenesis
Scientists investigated whether direct or indirect cell-cell contact between articular chondrocytes and mesenchymal stromal cells is essential for increased cartilage production in different cellular environments and elucidated the mechanisms behind these cellular interactions. [Tissue Eng Part A] Abstract

Cultured Human Adipose Tissue Pericytes and Mesenchymal Stromal Cells Display a Very Similar Gene Expression Profile
Both mesenchymal stromal cells and cultured pericytes were able to differentiate along mesenchymal pathways in vitro, displayed an essentially identical surface immunophenotype, and exhibited the ability to suppress CD3+ lymphocyte proliferation in vitro. [Stem Cells Dev] Abstract

Different Procoagulant Activity of Therapeutic Mesenchymal Stromal Cells Derived from Bone Marrow and Placental Decidua
The authors present a first safety follow-up on clinical experience with placenta-derived decidual stromal cells (DSCs), used as supportive immunomodulatory and regenerative therapy for patients with severe complications after allogeneic hematopoietic stem cell transplantation. They found that DSCs are smaller, almost half the volume of mesenchymal stromal/stem cells, which may favor microvascular passage. [Stem Cells Dev] Abstract

Pre-Stimulation with FGF-2 Increases In Vitro Functional Coupling of Mesenchymal Stem Cells with Cardiac Cells
The authors investigated how the pre-treatment with growth factors modulates mesenchymal stem cell ability to integrate into the host tissue after transplantation, with particular focus on the expression of Cx43 and its cellular distribution. [Biochem Biophys Res Commun] Abstract

Expression of Human Telomerase Reverse Transcriptase Mediates the Senescence of Mesenchymal Stem Cells through the PI3K/AKT Signaling Pathway
Scientists found that senescence was associated with human telomerase reverse transcriptase (hTERT) expression, and telomere length and telomerase activity. They established a short interfering RNA targeting hTERT and a gene expression vector carrying hTERT and transfected these into the mesenchymal stem cells (MSCs) to investigate the detailed role and the underlying molecular mechanisms of action of hTERT in MSCs. [Int J Mol Med] Abstract

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Organ-Specific Migration of Mesenchymal Stromal Cells: Who, When, Where and Why?
The authors focus on the migratory potential of mesenchymal stromal cells (MSC) to target organs, including bone marrow, bone, spleen & lymph nodes, intestine and heart, and the underlying molecular mechanisms in various preclinical and clinical settings. Better understanding of directed MSC migration will offer new perspectives to modulate MSC expansion and/or clinical protocols to improve their efficacy upon transplantation. [Immunol Lett] Abstract

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Stem Cells & Regenerative Medicine Congress 2015
Medtown Ventures, LLC Announces Exclusive License Agreement with Georgia Tech Research Corporation
Medtown Ventures, LLC announced that it has entered into an exclusive license agreement with Georgia Tech Research Corporation for a new adhesive-signature based stem cell selection and isolation technology. [Medtown Ventures, LLC] Press Release

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Therapeutic Goods Administration (Australia)
NEW ISCBC 2015: International Stem Cell Biology Conference
October 11-12, 2015
Osaka, Japan

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Cell Biology Lab Manager (Harvard Apparatus Regenerative Technology)

NEW Science Writer (Houston Methodist Research Institute)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Research Fellow – Fat Metabolism and Stem Cells (Singapore Bioimaging Consortium)

Researcher – Stem Cell Research (Helse Bergen – Haukeland University Hospital)

Scientific Writer – Stem Cells and Regenerative Medicine (University of Washington)

Postdoctoral Fellow – Stem Cell Biology (INSERM)

Research Scientist – Stem Cell Biology (ODU Research Foundation)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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