Volume 7.30 | Aug 4

Mesenchymal Cell News 7.30 August 4, 2015
Mesenchymal Cell News
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hMSC-Derived VEGF Release Triggers the Chemo-Attraction of Alveolar Osteoblasts
Scientists showed by live cell imaging that in interactive cocultures, human mesenchymal stem cells (hMSCs) successfully trigger osteoblast chemotaxis. They showed that only corresponding levels of vascular endothelial growth factor (VEGF) but not osteoprotegerin attracted alveolar osteoblasts similar to hMSC coculture, while VEGF inhibitor abolished both the VEGF and the hMSC-triggered chemo-attraction. [Stem Cells] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
A Computer-Designed Scaffold for Bone Regeneration within Cranial Defect Using Human Dental Pulp Stem Cells
Researchers used a computer-designed, solvent-free scaffold and human dental pulp stem cells (hDPSCs) to regenerate neo-bone within cranial bone defects. The hDPSCs expressed mesenchymal stem cell markers and served as an abundant source of stem cells with a high proliferation rate. [Sci Rep] Full Article

Mesenchymal Stem Cell Expression of SDF-1β Synergizes with BMP-2 to Augment Cell-Mediated Healing of Critical-Sized Mouse Calvarial Defects
The authors tested the hypothesis that stromal cell-derived factor-1β (SDF-1β) overexpressed in Tet-Off-SDF-1β bone marrow-derived mesenchymal stem/stromal cells (BMSCs), delivered on acellular dermal matrix, synergistically augments bone morphogenetic protein-2 (BMP-2)-induced healing of critical-sized mouse calvarial defects. BMSC therapies alone showed limited bone healing, which was increased with co-delivery of BMP-2. [J Tissue Eng Regen Med] Abstract

Growth Factors Cross-Linked to Collagen Microcarriers Promote Expansion and Chondrogenic Differentiation of Human Mesenchymal Stem Cells
Collagen microcarriers cross-linked with basic fibroblast growth factor or transforming growth factor-β1 were used for expansion and chondrogenic differentiation of human mesenchymal stem cells. Evaluation methods included cell viability test, chondrogenic marker expression, histological detection of proteoglycans and immunohistochemical analysis. [Tissue Eng Part A] Abstract

Mouse White Adipose Tissue-Derived Mesenchymal Stem Cells Gain Pericentral and Periportal Hepatocyte Features after Differentiation In Vitro, which Are Preserved In Vivo after Hepatic Transplantation
Adipose tissue-derived mesenchymal stem cells were isolated from immunodeficient C57BL/6 mice and differentiated into the hepatocytic phenotype by applying a simple protocol. Their physiological and metabolic functions were analyzed in vitro and after hepatic transplantation in vivo. [Acta Physiol] Abstract

Differential Expression of Adhesion-Related Proteins and MAPK Pathways Leads to Suitable Osteoblast Differentiation of Human Mesenchymal Stem Cells Subpopulations
Investigators analyzed the expression profiles of adhesion-related proteins during osteoblastic differentiation of two human mesenchymal stem cells subpopulations and proposed a strategy for assembling bone grafts based on its adhesion ability. [Stem Cells Dev] Abstract

Effects of Tanshinone IIA on Osteogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells
Both ALP activity at day 7 and calcium content at day 24 were upregulated during the osteogenesis of mouse bone marrow mesenchymal stem cells treated with tanshinone IIA (TSA), demonstrating that it promoted the osteogenesis at both early and late stages. They found that TSA promoted osteogenesis and inhibited osteoclastogenesis, evident by RT-PCR analysis of osteogenic marker gene expressions. [Naunyn Schmiedebergs Arch Pharmacol] Abstract

Osteogenic Potential of In Vitro Osteo-Induced Adipose-Derived Mesenchymal Stem Cells Combined with Platelet-Rich Plasma in an Ectopic Model
The osteogenic potential of in vitro osteo-induced adipose-derived mesenchymal stem cells combined with platelet-rich plasma and implanted on bone mineral matrix carrier was examined in a subcutaneous model in Balb/c mice. [Int Orthop] Abstract

Adipose-Derived Mesenchymal Stem Cells Ameliorate Ulcerative Colitis through miR-1236 Negatively Regulating the Expression of Retinoid-Related Orphan Receptor Gamma
The authors investigated the effect of adipose-derived mesenchymal stem cells on 2,4,6-trinitrobenzenesulfonic acid-induced ulcerative colitis in rat colon tissues. qRT-PCR and immunofluorescence analyses were performed to monitor the expression of miR-1236 and its target molecule, retinoid-related orphan receptor γ. [DNA Cell Biol] Abstract

Effects of Angular Frequency during Clinorotation on Mesenchymal Stem Cell Morphology and Migration
Scientists investigated the effects of clinorotation speed on the morphology, cytoarchitecture, and migration behavior of human mesenchymal stem cells. [NPJ Microgravity] Full Article

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Mesenchymal Stem Cells in Autism Spectrum and Neurodevelopmental Disorders: Pitfalls and Potential Promises
The relevant literature in autism spectrum disorders and other neurodevelopmental disorders regarding immune dysregulation and neuroinflammation and relevant therapeutics with mesenchymal stem cell infusion is reviewed. The relevant literature pertaining to mesenchymal stem cells and their clinical applications is also reviewed. [World J Biol Psychiatry] Abstract

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The Musculoskeletal Transplant Foundation Agrees to Invest in AmnioChor
AmnioChor Inc. announced that the Musculoskeletal Transplant Foundation of Edison NJ has agreed to invest in their seed round of development of the proprietary AmnioCept™ product line and OmniBank placental tissue storage capabilities. AmnioChor’s products are intended to augment umbilical cord blood, and will additionally contain epithelial and mesenchymal stem cells that may be used in technologies including 3-D printing of human organs. [AmnioChor Inc. (PR Newswire Association LLC)] Press Release

Cynata Collaborates with University of Sydney to Evaluate Cymerus™ MSCs for Heart Disease
Cynata Therapeutics Ltd announced that it has initiated a collaboration with the University of Sydney to test the potential therapeutic efficacy of its Cymerus™ mesenchymal stem cells (MSCs) in animal models of myocardial infarction (heart attack) and associated heart rhythm abnormalities. [Cynata Therapeutics Ltd] Press Release

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NEW World Conference on Regenerative Medicine 2015
October 21-23, 2015
Leipzig, Germany

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NEW Professorship – Cellular and/or Molecular Biology and Immunology (Nanjing University)

Cellular Therapy Faculty (University of California, San Diego)

Cell Biology Lab Manager (Harvard Apparatus Regenerative Technology)

Science Writer (Houston Methodist Research Institute)

Researcher – Stem Cell Research (Helse Bergen – Haukeland University Hospital)

Scientific Writer – Stem Cells and Regenerative Medicine (University of Washington)

Postdoctoral Fellow – Stem Cell Biology (INSERM)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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