Volume 7.32 | Aug 18

Mesenchymal Cell News 7.32 August 18, 2015
Mesenchymal Cell News
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DKK1 Rescues Osteogenic Differentiation of Mesenchymal Stem Cells Isolated from Periodontal Ligaments of Patients with Diabetes Mellitus Induced Periodontitis
The authors found multiple differentiation potential of mesenchymal stem cells derived from periodontal ligament (PDLSCs) from chronic periodontitis with diabetes mellitus donors (D-PDLSCs) was damaged significantly. Inhibition of NF-κB signaling could rescue osteogenic potential of PDLSCs from simple chronic periodontitis patients. [Sci Rep] Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Comparative Efficacy of Intracoronary Allogeneic Mesenchymal Stem Cells and Cardiosphere-Derived Cells in Swine with Hibernating Myocardium
Allogeneic intracoronary allogeneic mesenchymal stem cells and intracoronary allogeneic cardiosphere-derived cells exhibited comparable therapeutic efficacy in a large animal model of hibernating myocardium. Both cell types produced equivalent increases in regional function and stimulated myocyte regeneration in ischemic and remote myocardium. [Circ Res] Abstract

Density-Dependent Metabolic Heterogeneity in Human Mesenchymal Stem Cells
Researchers investigated the metabolic profiles of different subpopulations of human mesenchymal stem cell (hMSC) by testing the hypothesis that the clonogenic hMSC subpopulation, which is selectively enriched in clonal density and low density culture, possesses a metabolic phenotype that differs from that of hMSC in medium- or high-density. [Stem Cells] Abstract

Mechano Growth Factor E Peptide Promotes Rat Bone Marrow-Derived Mesenchymal Stem Cell Migration through CXCR4-ERK1/2
The authors determined that mechano growth factor (MGF)-25E induced the migration of rat bone marrow-derived mesenchymal stem cells (rMSCs) by modulating CXCR4 to activate the extracellular signal-regulated kinase 1/2 (ERK1/2) pathway. The analysis of the Young’s modulus and F-actin remodeling indicated that MGF-25E increased the stiffness and the F-actin polymerization of rMSCs through the activation of the CXCR4-ERK1/2 pathway. [Growth Factors] Abstract

Osteogenic Differentiation and Proliferation of Bone Marrow-Derived Mesenchymal Stromal Cells on PDLLA+BMP-2-Coated Titanium Alloy Surfaces
Investigators compared the osteogenic differentiation and proliferation of hMSC on native polished vs. sandblasted titanium surfaces (TS) and tested their behavior on pure poly-D,L-lactide (PDLLA) coated as well as PDLLA+rhBMP-2 coated TS. [J Biomed Mater Res A] Abstract

Direct Intercellular Communications Dominate the Interaction between Adipose-Derived MSCs and Myofibroblasts against Cardiac Fibrosis
In order to decipher the potential mechanism of mesenchymal stem cell (MSC) therapy for cardiac fibrosis, researchers investigated the interplay between MSCs and cardiac myofibroblasts using interactive co-culture method, with comparison to paracrine approaches, namely treatment by MSC conditioned medium and gap co-culture method. [Protein Cell] Full Article

Role of C-Jun N-Terminal Kinase in the Osteogenic and Adipogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells
Scientists explored the possible role of JNKs in osteogenesis and adipogenesis of adipose-derived mesenchymal stem cells. Inhibition of the JNK signaling pathway using SP600125 blocked osteogenic differentiation in a dose-dependent manner, which was revealed by an ALP activity assay, extracellular calcium deposition detection, and expression of osteogenesis-relative genes via RT-PCR and real-time PCR. [Exp Cell Res] Abstract

Peroxisome Proliferator-Activated Receptor Gamma Promotes Mesenchymal Stem Cells to Express Connexin43 via the Inhibition of TGF-β1/Smads Signaling in a Rat Model of Myocardial Infarction
The authors hypothesized that activation of peroxisome proliferator-activated receptor-γ enhanced mesenchymal stem cell survival and their therapeutic efficacy via upregulating the expression of connexin43. [Stem Cell Rev] Abstract

Assessment of Long-Term Safety and Efficacy of Intranasal Mesenchymal Stem Cell Treatment for Neonatal Brain Injury in the Mouse
Researchers assessed whether intranasal mesenchymal stem cell (MSC) treatment after hypoxia-ischemia induces neoplasia in the brain or periphery at 14 months. Furthermore, the long-term effects of MSCs on behavior and lesion size were determined. [Ped Res] Abstract

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Mesenchymal Stem/Stromal Cells as a Delivery Platform in Cell and Gene Therapies
This review deals with the therapeutic properties of mesenchymal stem/stromal cell, focusing on their ability to secrete naturally produced or gene-induced factors that can be used in the treatment of kidney, lung, heart, liver, pancreas, nervous system, and skeletal diseases. [BMC Med] Full Article

Research Using Mesenchymal Stem/Stromal Cells: Quality Metric towards Developing a Reference Material
Establishing more than minimal criteria to define mesenchymal stem/stromal cells (MSCs) would help understand best protocols to isolate, propagate and deliver MSCs. Developing a calibration standard, a database and a set of functional tests would be a better quality metric for MSCs. The authors discuss the importance of selecting a standard, issues associated with coming up with such a standard and how these issues can be mitigated. [Cytotherapy] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

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First Patient Treated in Progenza Stem Cell Trial
Regeneus has enrolled and treated the first patient under the Phase I clinical trial of its Progenza off-the-shelf allogeneic stem cell treatment for knee osteoarthritis. [Regeneus Ltd] Press Release

Stemedica Awarded U.S. Patent for Transgenic Therapeutic Stem Cells
Stemedica Cell Technologies Inc. received United States Patent No. 9080184 entitled “Transgenic Therapeutic Stem Cells and Methods for Their Use and Manufacture.” [Stemedica Cell Technologies, Inc.] Press Release

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NEW The 3rd International Congress on Controversies in Stem Cell Transplantation and Cellular Therapies (COSTEM)
October 22-24, 2015
Berlin, Germany

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Junior Group Leader – Cell and Development Biology Program (Centre for Genomic Regulation)

Postdoctoral Biologist/Cytogeneticist Researcher – Genomic Stability of Cultured HSCs and MSCs (University of Crete)

Professorship – Cellular and/or Molecular Biology and Immunology (Nanjing University)

Cellular Therapy Faculty (University of California, San Diego)

Cell Biology Lab Manager (Harvard Apparatus Regenerative Technology)

Science Writer (Houston Methodist Research Institute)

Scientific Writer – Stem Cells and Regenerative Medicine (University of Washington)

Postdoctoral Fellow – Stem Cell Biology (INSERM)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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