Volume 7.33 | Aug 25

Mesenchymal Cell News 7.33 August 25, 2015
Mesenchymal Cell News
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How Newts Can Help Osteoarthritis Patients
Scientists have taken a leaf out of nature’s book in an attempt to develop effective stem cell treatment for osteoarthritis. They adapted the astonishing capacity of animals such as newts to regenerate lost tissues and organs caused when they have a limb severed. [Press release from University of York discussing online publication in Scientific Reports] Press Release | Full Article
NEW: Animal Component-Free MSC Chondrogenic Differentiation - Learn More
PUBLICATIONS (Ranked by impact factor of the journal)
Gene-Expression and In Vitro Function of Mesenchymal Stromal Cells Are Affected in Juvenile Myelomonocytic Leukemia
Scientists investigated the impact of juvenile myelomonocytic leukemia on mesenchymal stromal cells. Mesenchymal stromal cells were expanded from bone-marrow samples of patients at diagnosis, after hematopoietic stem cell transplantation and healthy children. Cells were characterized by phenotyping, differentiation, gene-expression analysis and in vitro functional studies assessing immunomodulation and hematopoietic support. [Haematologica] Abstract

The Role of Scleraxis in Fate Determination of Mesenchymal Stem Cells for Tenocyte Differentiation
Scientists demonstrated scleraxis, a transcription factor critically involved in embryonic tendon development and formation, plays a pivotal role in the fate determination of mesenchymal stem cell towards tenocyte differentiation. [Sci Rep] Full Article

Thermoresponsive Substrates Used for the Growth and Controlled Differentiation of Human Mesenchymal Stem Cells
One μm thick solvent cast films were not only capable of hosting an expanding population of phenotypically preserved human mesenchymal stem cells similar to tissue culture plastic controls, but also the cells detached via temperature control better maintained their ability to differentiate compared to conventionally trypsinized cells. [Macromol Rapid Commun] Abstract

Multiple Myeloma and Bone Marrow Mesenchymal Stem Cells’ Crosstalk: Effect on Translation Initiation
The authors demonstrated that there was direct dialogue between multiple myeloma and bone marrow-mesenchymal stem cell populations that included translation initiation manipulation and critically affects cell fate. [Mol Carcinog] Abstract

Foxp3-Modified Bone Marrow Mesenchymal Stem Cells Promotes Liver Allograft Tolerance through the Generation of Regulatory T Cells in Rats
Successful gene transfer of forkhead box P3 (Foxp3) in mesenchymal stem cells (MSCs) was achieved by lentivirus carrying Foxp3 and Foxp3-MSC engraftment in liver allograft was confirmed by fluorescence microscopy. Foxp3-MSC treatment significantly inhibited the proliferation of allogeneic ACI CD4+ T cells to splenocytes from the same donor strain or third-party BN rat compared with MSC. [J Transl Med] Full Article

Enhancement of the Immunoregulatory Potency of Mesenchymal Stromal Cells by Treatment with Immunosuppressive Drugs
Researchers showed that brief incubations with rapamycin, everolimus, FK506 or cyclosporine A increased the immunosuppressive potency of mesenchymal stromal cells and other cell types. [Cytotherapy] Abstract

High-Fat Diet/Low-Dose Streptozotocin-Induced Type 2 Diabetes in Rats Impacts Osteogenesis and Wnt Signaling in Bone Marrow Stromal Cells
The authors investigated the osteogenic potential of bone marrow stromal cells (BMSCs) derived from type 2 diabetic rats and the pathogenic characteristics of dysfunctional BMSCs that affect osteogenesis. [PLoS One] Full Article

Pre-Differentiation of Mesenchymal Stromal Cells in Combination with a Microstructured Nerve Guide Supports Peripheral Nerve Regeneration in the Rat Sciatic Nerve Model
20 mm rat sciatic nerve defects were implanted with a cell-seeded microstructured collagen nerve guide (Perimaix) or an autologous nerve graft. Under the influence of seeded, pre-differentiated mesenchymal stromal cells, axons regenerated well into the Perimaix nerve guide. [Eur J Neurosci] Abstract

Rap1-Mediated Nuclear Factor-KappaB (NF-κB) Activity Regulates the Paracrine Capacity of Mesenchymal Stem Cells in Heart Repair following Infarction
Researchers examined how Rap1, telomeric repeat-binding factor 2-interacting protein 1, which is a novel modulator involved in the NF-κB pathway, regulates the paracrine effects of mesenchymal stem cell-mediated heart repair following infarction. [Cell Death Discov] Full Article

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Where Is the Common Ground between Bone Marrow Mesenchymal Stem/Stromal Cells from Different Donors and Species?
The authors discuss promising marker combinations for prospective mesenchymal stem/stromal cells (MSC) subpopulation enrichment and expansion, and reflects MSC phenotype changes due to environment and age. [Stem Cell Res Ther] Full Article

Mesenchymal Stem Cells for the Treatment of Neurological Diseases: Immunoregulation Beyond Neuroprotection
The authors review the evidence, mostly deriving from preclinical studies, that mesenchymal stromal/stem cells, beyond their ability to foster neurorepair, can ameliorate neurodegenerative diseases through their effect on associated immune responses. [Immunol Lett] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

IBC’s Cell Therapy Bioprocessing & Commercialization meeting
Esperite Acquires Patent to Use MSC-Derived Exosomes for Broad Applications in Immunology
Esperite has acquired the full rights of a broad international patent enabling MSC-derived exosomes use in treatment of inflammatory and autoimmune diseases. This exosome technology will permit development of more effective, safer and affordable therapies as an alternative to allogeneic MSCs. [Esperite N.V.] Press Release

Ocata Therapeutics Receives SBIR Grant from NIH to Develop Proprietary Hemangio-Derived Mesenchymal Cell Therapy for Lupus Nephritis
Ocata Therapeutics, Inc. announced that it has been awarded a Small Business Innovation Research (SBIR) Phase I grant from the National Institute of Allergy and Infectious Diseases to fund further preclinical development of Ocata’s proprietary hemangio-derived mesenchymal cell product for the treatment of systemic lupus erythematosus and lupus nephritis. [Ocata Therapeutics, Inc.] Press Release

$52 Million NIH Grant Advances Clinical and Translational Research at UC San Diego
The Clinical and Translational Research Institute at University of California, San Diego has received a five-year Clinical and Translational Science Award for approximately $52 million from the National Center for Advancing Translational Science, part of the National Institutes of Health (NIH). [UC San Diego Health] Press Release

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NEW 3rd Annual Cell Culture & Bioprocessing Asia Congress 2015
October 15-16, 2015
Singapore, Singapore

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Postdoctoral Fellow – Cardiovascular Stem Cell Biology and Tissue Engineering (Yale University)

Junior Group Leader – Cell and Development Biology Program (Centre for Genomic Regulation)

Postdoctoral Biologist/Cytogeneticist Researcher – Genomic Stability of Cultured HSCs and MSCs (University of Crete)

Professorship – Cellular and/or Molecular Biology and Immunology (Nanjing University)

Cellular Therapy Faculty (University of California, San Diego)

Cell Biology Lab Manager (Harvard Apparatus Regenerative Technology)

Postdoctoral Fellow – Stem Cell Biology (INSERM)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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