Volume 7.34 | Sep 1

Mesenchymal Cell News 7.34 September 1, 2015
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
In Vitro-Conditioned Bone Marrow-Derived Mesenchymal Stem Cells (BMSC) Promote De Novo Functional Enteric Nerve Regeneration, but Not through Direct-Transdifferentiation
Scientists, using the BAC-induced rat gastric denervation model, aimed to determine whether transplantation of BMSC could promote enteric nervous system neuron regeneration and if so, to elucidate the mechanism. [Stem Cells] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Perivascular Mesenchymal Stem Cells from the Adult Human Brain Harbor No Instrinsic Neuroectodermal but High Mesodermal Differentiation Potential
Investigators systematically characterized adult human brain-derived pericytes during in vitro expansion and differentiation and compared these cells with fetal and adult human brain-derived neural stem cells and adult human bone marrow-derived mesenchymal stem cells. [Stem Cells Transl Med] Abstract

Health Span-Extending Activity of Human Amniotic Membrane- and Adipose Tissue-Derived Stem Cells in F344 Rats
Human amniotic membrane-derived mesenchymal stem cells (AMMSCs) or adipose tissue-derived mesenchymal stem cells (ADMSCs) were intravenously transplanted to 10-month-old male F344 rats once a month throughout their lives. Transplantation of AMMSCs and ADMSCs improved cognitive and physical functions of naturally aging rats, extending life span by 23.4% and 31.3%, respectively. [Stem Cells Transl Med] Abstract | Press Release

Bile Acids Induce Hepatic Differentiation of Mesenchymal Stem Cells
Since bile acids can promote liver regeneration, their influence on liver-resident and bone marrow-derived mesenchymal stem cells (MSC) was investigated. Physiological concentrations of bile acids such as tauroursodeoxycholic acid were able to initiate hepatic differentiation of MSC via the farnesoid X receptor and transmembrane G-protein-coupled bile acid receptor 5 as investigated with knockout mice. [Sci Rep] Full Article

Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses
Scientists found that, along with Th1 responses, hMSCs strongly suppressed interleukin-17A (IL-17A)-secreting T (Th17) responses and this required both IL-25—also known as IL-17E—as well as programmed death ligand-1 (PD-L1), a potent cell surface ligand for tolerance induction. [Stem Cell Rep] Full Article | Graphical Abstract

Isolation, Selection and Culture Methods to Enhance Clonogenicity of Mouse Bone Marrow Derived Mesenchymal Stromal Cell Precursors
The authors aimed to optimize the isolation, culture conditions and selection of mouse bone marrow mesenchymal stromal cells. [Stem Cell Res Ther] Full Article

Human Amniotic Mesenchymal Stromal Cells (hAMSCs) as Potential Vehicles for Drug Delivery in Cancer Therapy: An In Vitro Study
The authors investigated mesenchymal stromal cells isolated from the amniotic membrane of human term placenta as candidates for drug delivery in vitro. [Stem Cell Res Ther] Full Article

Human Tubal-Derived Mesenchymal Stromal Cells Associated with Low Level Laser Therapy Significantly Reduces Cigarette Smoke–Induced COPD in C57BL/6 Mice
Scientists studied the effectiveness of human tube derived mesenchymal stromal cells cell therapy associated with low level laser irradiation in experimental cigarette smoke-induced chronic obstructive pulmonary disease. [PLoS One] Full Article

Human Schwann-Like Cells from Adipose-Derived Mesenchymal Stem Cells Rapidly De-Differentiate in the Absence of Stimulating Media
Researchers examined the stability of differentiated adipose-derived stem cells (dASC) by withdrawing differentiation media for 72 hours after the full 18-day differentiation protocol, and measuring changes in morphology, gene expression and protein levels. Withdrawal of differentiation media from dASC resulted in a rapid reversion to stem cell-like characteristics. [Eur J Neurosci] Abstract

Role of Suppressor of Cytokine Signaling 3 in the Immune Modulation of Mesenchymal Stromal Cells
The authors showed that the suppressor of cytokine signaling 3 is an important immune modulator expressed by mesenchymal stromal cells, which is significantly increased by interferon-γ. [Inflammation] Abstract

Type I and II Diabetic Adipose-Derived Stem Cells Respond In Vitro to Dehydrated Human Amnion/Chorion Membrane Allograft Treatment by Increasing Proliferation, Migration, and Altering Cytokine Secretion
Dehydrated human amnion/chorion membrane allografts were evaluated for their ability to regulate diabetic stem cells in vitro. [Adv Wound Care] Abstract | Press Release

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REVIEWS
Process Development Considerations for Cell Therapy
The authors present an introduction to the process development challenges of cell therapies and describe some of the tools available to address production issues. They provide a summary of what should be considered to efficiently advance a cellular therapy from the research stage through clinical trials and finally toward commercialization. [Stem Cells Transl Med] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Stem Cell Asia Congress
 
INDUSTRY NEWS
NIH Awards Nearly $34 Million to UAB Center for Clinical and Translational Science
The National Institutes of Health (NIH) has awarded the University of Alabama at Birmingham (UAB) Center for Clinical and Translational Science $33.59 million over four years to continue the center’s programs advancing translational research. [University of Alabama at Birmingham] Press Release

Cell Therapy Catapult Welcomes Planning Decision for Manufacturing Center
The Cell Therapy Catapult has welcomed the decision by Stevenage Borough Council to grant planning permission to construct its £55 million large-scale GMP manufacturing center. [Cell Therapy Catapult] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Targeting Cell Death Mechanisms for the Treatment of Human Diseases
November 9-13, 2015
Suzhou, China

Visit our events page to see a complete list of events in the mesenchymal cell community.
 
JOB OPPORTUNITIES
NEW Cellular Therapy Lab Technologist (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Cardiovascular Stem Cell Biology and Tissue Engineering (Yale University)

Junior Group Leader – Cell and Development Biology Program (Centre for Genomic Regulation)

Professorship – Cellular and/or Molecular Biology and Immunology (Nanjing University)

Cellular Therapy Faculty (University of California, San Diego)

Cell Biology Lab Manager (Harvard Apparatus Regenerative Technology)

Postdoctoral Fellow – Stem Cell Biology (INSERM)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)


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