Volume 7.35 | Sep 8

Mesenchymal Cell News 7.35 September 8, 2015
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Mesenchymal Stromal Cell-Derived PTX3 Promotes Wound Healing via Fibrin Remodeling
Using a murine model of skin repair, investigators found that pentraxin 3 (Ptx3)−/− mesenchymal stromal cells (MSCs) delayed wound closure and reduced granulation tissue formation compared with wt MSCs. Ptx3−/− MSC-treated skins displayed increased levels of fibrin and lower levels of D-dimer, suggesting a delayed fibrin-rich matrix remodeling compared to control skins. [J Invest Dermatol] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Physical Intimacy of Breast Cancer Cells with Mesenchymal Stem Cells Elicits Trastuzumab Resistance through Src Activation
Using an in vitro patterned breast cancer/mesenchymal stem cell (MSC) co-culture model, scientists found that the presence of MSCs results in Src activation that is missing in cancer cells monoculture, transwell co-culture, and cells treated with MSCs conditioned media. [Sci Rep] Full Article

Mesenchymal Stromal Cells Differentiating to Adipocytes Accumulate Autophagic Vesicles Instead of Functional Lipid Droplets
The authors investigated the structural and functional features of bone marrow mesenchymal stromal cells (BMSCs)-derived adipocytes as compared with adipocytes from adipose tissue, and the structure and functionality of lipid vesicles formed during BMSCs differentiation to adipocytes. [J Cell Physiol] Abstract

Femtosecond Laser Nano/Micro Patterning of Titanium Influences Mesenchymal Stem Cell Adhesion and Commitment
Three biomimetic textures were fabricated on titanium surface: micropits with nano-ripples in the pits, micropits with nano-ripples around the pits, and a texture with only nano-ripples. Mesenchymal stem cells grown on these surfaces displayed altered morphometric parameters, and modified their focal adhesions in term of number, size, and distribution depending on surface type. [Biomed Mater] Abstract

Migrational Changes of Mesenchymal Stem Cells in Response to Cytokines, Growth Factors, Hypoxia, and Aging
Using the in vitro scratch assay, scientists showed that the inflammatory cytokines, chemokines, and growth factors TNF-α, SDF-1, PDGF, and bFGF enhance migration of rat mesenchymal stem cells (MSCs) under normoxic conditions, while TNF-α, IFN-γ, PDGF, and bFGF promote MSC migration under hypoxic conditions. [Exp Cell Res] Abstract

Activation of PKA/CREB Signaling Is Involved in BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells
Researchers explored the detailed role of PKA/CREB signaling in BMP9-induced osteogenic differentiation. Using PKA inhibitors and a dominant negative protein of CREB, they investigated the effect of PKA/CREB signaling on BMP9-induced osteogenic differentiation. [Cell Physiol Biochem] Full Article

BMP3 Alone and Together with TGF-β Promote the Differentiation of Human Mesenchymal Stem Cells into a Nucleus Pulposus-Like Phenotype
Mesenchymal stem cells (MSCs) were cultured with various gradients of bone morphogenetic protein 3 (BMP3) and BMP3/transforming growth factor (TGF)-β, and compared with cultures in basal and TGF-β media. Cell proliferation, glycosaminoglycan content, gene expression, and signaling proteins were measured to assess the effects of BMP3 and BMP3/TGF-β on MSCs. [Int J Mol Sci] Abstract | Download Full Article

Mesenchymal Stromal Cells Derived from Cervical Cancer Tumors Induce TGF-β1 Expression and IL-10 Expression and Secretion in the Cervical Cancer Cells, Resulting in Protection from Cytotoxic T Cell Activity
Researchers provide evidence that mesenchymal stromal cells (MSCs) derived from cervical tumors (CeCa) cocultured with CeCa cells induced significant expression of TGF-β1 and secretion of IL-10 by CeCa cells compared to MSCs derived from the normal cervix and normal bone marrow. [Cytokine] Abstract

Bone-Marrow Derived Mesenchymal Stem Cells Assembled with Low Dose BMP-2 in a Three Dimensional Hybrid Construct Enhances Posterolateral Spinal Fusion in Syngeneic Rats
Scientists hypothesized that the synergistic osteoinductive capacity of low dose bone bone morphogenetic protein 2 (BMP-2) combined with undifferentiated bone marrow derived stromal cells (BMSCs) is comparable to that of osteogenically differentiated BMSCs when used in a rodent model of posterolateral spinal fusion. [Spine J] Abstract

The Characteristics of Human Cranial Bone Marrow Mesenchymal Stem Cells
Bone marrow-derived mesenchymal stem cells from cranial bone waste and cells obtained from the iliac crest showed expression of cell surface markers associated with mesenchymal stem cells and multipotency traits such as differentiation into osteogenic and adipogenic lineages. [Neurosci Lett] Abstract

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REVIEWS
Small Molecules and Their Controlled Release that Induce the Osteogenic/Chondrogenic Commitment of Stem Cells
The authors review a series of small molecules that can induce or/and promote the osteogenic/chondrogenic commitment of stem cells. The controlled release of these small molecules from various vehicles for stem cell-based therapies and tissue engineering applications is also discussed. [Biotechnol Adv] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

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INDUSTRY NEWS
Mesoblast Partner JCR Pharmaceuticals Receives Recommendation for Approval of Mesenchymal Stem Cell Product in Japan
Mesoblast Limited announced that the allogeneic mesenchymal stem cell-based regenerative medicine product JR-031, developed by Mesoblast’s Japanese partner JCR Pharmaceuticals Co. Ltd., was recommended for approval at a meeting organized by the Committee on Regenerative Medicine Products and Biological Technology of Pharmaceutical Affairs and Food Sanitation Council of the Japan Ministry of Health, Labour and Welfare. [Mesoblast Limited (GlobeNewswire, Inc.)] Press Release

BioLife Solutions Customer TiGenix Phase III Clinical Trial Meets Primary Endpoint
BioLife Solutions, Inc. announced that its customer TiGenix NV, a biopharmaceutical company focused on developing and commercializing novel therapeutics from its proprietary platforms of allogeneic expanded stem cells, recently disclosed that its lead compound Cx601 met the primary endpoint in the Phase III ADMIRE-CD trial of complex perianal fistula in Crohn’s Disease patients. [BioLife Solutions, Inc.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 2nd Annual Matrix Biology Ireland (MBI) Meeting 2015
December 1-4, 2015
Dublin, Ireland

Visit our events page to see a complete list of events in the mesenchymal cell community.
 
JOB OPPORTUNITIES
NEW Faculty Position – Life Sciences (Stowers Institute for Medical Research)

NEW Faculty Positions – Stem Cells and Regenerative Medicine (King Abdullah University of Science and Technology)

Postdoctoral Fellow – Cardiovascular Stem Cell Biology and Tissue Engineering (Yale University)

Junior Group Leader – Cell and Development Biology Program (Centre for Genomic Regulation)

Professorship – Cellular and/or Molecular Biology and Immunology (Nanjing University)

Cellular Therapy Faculty (University of California, San Diego)

Cell Biology Lab Manager (Harvard Apparatus Regenerative Technology)

Postdoctoral Fellow – Stem Cell Biology (INSERM)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)


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