Volume 7.36 | Sep 15

Mesenchymal Cell News 7.36 September 15, 2015
Mesenchymal Cell News
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MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus
Researchers showed that mesenchymal stem cell transplantation rescues bone marrow MSC (BMMSC) function and ameliorates osteopenia in Fas-deficient-MRL/lpr mice. Mechanistically, they showed that Fas deficiency causes failure of miR-29b release, thereby elevating intracellular miR-29b levels, and downregulates DNA methyltransferase 1 expression in MRL/lpr BMMSCs. [Cell Metab] Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
VEGF Therapeutic Gene Delivery Using Dendrimer Type Bio-Reducible Polymer into Human Mesenchymal Stem Cells (hMSCs)
The authors examined the possibility of performing gene therapy using the biodegradable polymeric non-viral vector Arginine-grafted poly (cystaminebisacrylamide-diaminohexane)-conjugated poly (amidoamine) dendrimer in hMSCs. Although hMSCs were transfected, their stem cell characteristics were retained. [J Control Release] Abstract

Electro-Magnetic Field Promotes Osteogenic Differentiation of BM-hMSCs through a Selective Action on Ca2+-Related Mechanisms
Scientists investigated the in vitro effect of pulsed electromagnetic field on Ca2+-related mechanisms promoting the osteogenic differentiation of human mesenchymal stem cells derived from bone marrow stroma (BM-hMSCs). [Sci Rep] Full Article

GPR120: A Bi-Potential Mediator to Modulate the Osteogenic and Adipogenic Differentiation of BMMSCs
The authors showed that GPR120 targeted the bi-potential differentiation of bone marrow mesenchymal stem cells (BMMSCs) in a ligand dose-dependent manner. [Sci Rep] Full Article

Transplantation of Hypoxia Preconditioned Bone Marrow Mesenchymal Stem Cells Enhances Angiogenesis and Osteogenesis in Rabbit Femoral Head Osteonecrosis
Investigators explored the novel strategy of hypoxia-preconditioned bone marrow mesenchymal stem cell (BMMSCs) to reverse the impairment of osteonecrosis BMMSCs and enhance the therapeutic potential of hypoxia-treated BMMSC transplantation. [Bone] Abstract

The Efficacy of Polycaprolactone/Hydroxyapatite Scaffold in Combination with Mesenchymal Stem Cells for Bone Tissue Engineering
Scientists determined the ability of polycaprolactone/hydroxyapatite for supporting cell growth, gene expression, and osteogenic differentiation in three types of mesenchymal stem cells, including bone marrow-derived mesenchymal stem cells, dental pulp stem cells and adipose-derived mesenchymal stem cells. [J Biomed Mater Res A] Abstract

Carbon Nanoparticle Induced Cytotoxicity in Human Mesenchymal Stem Cells through Upregulation of TNF3, NFKBIA and BCL2L1 genes
The authors focused on the cellular toxicity of carbon nanoparticles (CNPs) on human mesenchymal stem cells. Following exposure to CNPs, cell viability, nuclear morphological changes, apoptosis and cell cycle progression were monitored. [Chemosphere] Abstract

Overexpression of Hif-1α in Mesenchymal Stem Cells Affects Cell-Autonomous Angiogenic and Osteogenic Parameters
Investigators overexpressed Hypoxia-inducible factor 1 (Hif-1)α in mesenchymal stem cells by using recombinant adenoviruses and investigated cell-autonomous effects. Overexpression of Hif-1α enhanced proliferation, migration, cell survival and expression of pro-angiogenic genes. [J Cell Biochem] Abstract

Human Mesenchymal Stem Cells Retain Multilineage Differentiation Capacity Including Neural Marker Expression after Extended In Vitro Expansion
To identify potential therapeutic suitability researchers examined human mesenchymal stem cells after extended expansion including morphological changes, potency and multilineage potential. [PLoS One] Full Article

Canine Platelet Lysate Is Inferior to Fetal Bovine Serum for the Isolation and Propagation of Canine Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stromal Cells
Scientists hypothesized that canine adipose tissue and bone marrow mesenchymal stromal cells (MSC) could be isolated and expanded equally in platelet lysate and fetal bovine serum at conventionally-used concentrations with differentiation of these MSC unaffected by choice of supplement. [PLoS One] Full Article

Multi-Lineage Potential Research of Bone Marrow Mesenchymal Stem Cells from Bama Miniature Pig
Bone marrow was collected from Bama miniature pigs to isolate bone marrow mesenchymal stem cells by a whole bone marrow culture method. They then examined their biological characteristics such as growth kinetics, surface antigen, and multi-lineage potential. [J Exp Zool B Mol Dev Evol] Abstract

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Role of Mesenchymal Stem Cell-Derived Fibrinolytic Factor in Tissue Regeneration and Cancer Progression
The authors introduce general functional properties of the fibrinolytic system, which go beyond its known function of fibrin clot dissolution (fibrinolysis). They focus on the role of the fibrinolytic system for mesenchymal stem cell (MSC) biology, summarizing our current understanding of the role of the fibrinolytic system for MSC recruitment and the functional consequences for tissue regeneration and cancer. [Cell Mol Life Sci] Abstract

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Stem Cell Specialists BioEden to Enter Strategic Alliance with Precious Cells Group
BioEden is teaming up with Precious Cells Group, a London based Medtech Company whose facilities specialize in enabling the harvesting and banking of stem cells from cord blood and peripheral blood derived stem cells amongst others platform technologies. [BioEden (PRWeb)] Press Release

Ogawa-Yamanaka Prize Founded at the Gladstone Institutes to Support Translational Stem Cell Research
The Gladstone Institutes presented the inaugural Ogawa-Yamanaka Stem Cell Prize to Masayo Takahashi, MD, PhD, a faculty member and project leader in the Laboratory for Retinal Regeneration at the RIKEN Centre for Developmental Biology in Japan. Dr. Takahashi was awarded the prize for her trailblazing work leading the first clinical trial to use induced pluripotent stem cells in humans. [Gladstone Institutes] Press Release

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Center for Biologics Evaluation and Research (United States)

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Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Cell Culture 2016
February 2-4, 2016
London, United Kingdom

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NEW Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Faculty Position – Life Sciences (Stowers Institute for Medical Research)

Faculty Positions – Stem Cells and Regenerative Medicine (King Abdullah University of Science and Technology)

Postdoctoral Fellow – Cardiovascular Stem Cell Biology and Tissue Engineering (Yale University)

Junior Group Leader – Cell and Development Biology Program (Centre for Genomic Regulation)

Professorship – Cellular and/or Molecular Biology and Immunology (Nanjing University)

Cell Biology Lab Manager (Harvard Apparatus Regenerative Technology)

Postdoctoral Fellow – Stem Cell Biology (INSERM)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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