Volume 7.37 | Sep 22

Mesenchymal Cell News 7.37 September 22, 2015
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Substrate Coupling Strength of Integrin-Binding Ligands Modulates Adhesion, Spreading, and Differentiation of Human Mesenchymal Stem Cells
Fluorescence microscopy showed that human mesenchymal stem cells (hMSCs) spread well and formed stable actin filamentous structure on HCS surfaces but not on LCS surfaces. hMSCs exhibited enhanced osteogenesis on HCS surfaces as revealed by the immunostaining results of multiple early osteogenic markers. [Nano Lett] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Abrogation of Age-Induced MicroRNA-195 Rejuvenates the Senescent Mesenchymal Stem Cells by Reactivating Telomerase
The authors present the first evidence that microRNA (miR)-195 overexpressed in old mesenchymal stem cells induces stem cell senescence deteriorating their regenerative ability by directly deactivating telomerase reverse transcriptase, and abrogation of miR-195 can reverse stem cell aging. [Stem Cells] Abstract

Systemic Administration of Human Bone Marrow-Derived Mesenchymal Stromal Cell Extracellular Vesicles Ameliorates Aspergillus Hyphal Extract-Induced Allergic Airway Inflammation in Immunocompetent Mice
Scientists determined whether xenogeneic administration of conditioned media or extracellular vesicles from human bone marrow-derived mesenchymal stromal cells would be effective in a model of mixed Th2/Th17, neutrophilic-mediated allergic airway inflammation, reflective of severe refractory asthma, induced by repeated mucosal exposure to Aspergillus hyphal extract in immunocompetent C57Bl/6 mice. [Stem Cells Transl Med] Abstract

Bone Marrow-Derived Mesenchymal Stem Cells Ameliorate Chronic High Glucose-Induced β-Cell Injury through Modulation of Autophagy
Researchers investigated whether bone marrow-derived mesenchymal stem cells could ameliorate chronic high glucose-induced β-cell injury through modulation of autophagy. [Cell Death Dis] Full Article

Olfactory Ecto-Mesenchymal Stem Cells Possess Immunoregulatory Function and Suppress Autoimmune Arthritis
Investigators found that mouse olfactory ecto-mesenchymal stem cells (MSCs) expressed higher transforming growth factor-beta and interleukin-10 levels than bone marrow-derived MSCs. [Cell Mol Immunol] Abstract

Correlation between In Vitro Expansion-Related Cell Stiffening and Differentiation Potential of Human Mesenchymal Stem Cells
Human mesenchymal stem cells were cultured and routinely passaged on tissue-culture polystyrene to investigate the correlation between cell stiffening and differentiation potency during in vitro aging. [Differentiation] Abstract

Preparation and Characterization of Directed, One-Day-Self-Assembled Millimeter-Size Spheroids of Adipose-Derived Mesenchymal Stem Cells
Scientists prepared millimeter-order spheroids of adipose-derived mesenchymal stem cells (ADSCs) by controlling the spheroid size. Notably, spheroid generation required only one-day of culture on charged culture dishes. Almost all spheroid-derived ADSCs were viable and produced adhesion molecules and growth factors, which play an important role in tissue regeneration. [J Biomed Mater Res A] Abstract

Basic Fibroblast Growth Factor Stimulates the Proliferation of Bone Marrow Mesenchymal Stem Cells in Giant Panda (Ailuropoda melanoleuca)
Researchers investigated the role of basic fibroblast growth factor (bFGF) on the proliferation of bone marrow-mesenchymal stem cells (MSCs) derived from giant panda. MSCs were cultured for cell proliferation analysis at 24, 48 and 72 hours following the addition of bFGF. [PLoS One] Full Article

Treatment of Perianal Fistulas with Human Embryonic Stem Cell-Derived MSCs: A Canine Model of Human Fistulizing Crohn’s Disease
Investigators evaluated the safety and efficacy of intralesional injection of human embryonic stem cell-derived mesenchymal stem/stromal cells (MSCs) in canine anal furunculosis dogs. [Regen Med]
Full Article | Press Release

Single CD271 Marker Isolates Mesenchymal Stem Cells from Human Dental Pulp
Investigators used different combinations of surface markers to isolate homogeneous populations of dental mesenchymal stem cells from heterogeneous dental pulp cells obtained from dental pulp tissue and compared their capacity to undergo multilineage differentiation. [Int J Oral Sci] Full Article

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REVIEWS
Mesenchymal Stem Cells: Identification, Phenotypic Characterization, Biological Properties and Potential for Regenerative Medicine through Biomaterial Micro Engineering of their Niche
The authors review the literature on the identification, phenotypic characterization and biological properties of mesenchymal stem cells and discuss their potential for applications in cell therapy and regenerative medicine. They also discuss strategies for biomaterial micro-engineering of the stem cell niche. [Methods] Abstract

Recent Advances in Serum-Free Microcarrier Expansion of Mesenchymal Stromal Cells: Parameters to Be Optimized
Mesenchymal stromal cells are being investigated for a variety of therapeutic indications. However, current 2D planar technology cannot meet the anticipated demand and a shift to serum-free microcarrier cultures is needed in order to meet the quality and quantity of cells required. The authors summarize several recent attempts to grow cells in such conditions, and identify several variables that affect cell expansion. [Biochem Biophys Res Commun] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
 
INDUSTRY NEWS
Full Product Approval in Japan Received by Mesoblast Licensee
Mesoblast Limited announced that its licensee JCR Pharmaceuticals Co. Ltd has received full approval from the Japanese Ministry of Health, Labour and Welfare for TEMCELL® HS Inj., an allogeneic mesenchymal stem cell product. [Mesoblast Limited (GlobeNewswire, Inc.)] Press Release

Federal Initiative Could Further Boost Personalized Medicine in U.S.
Hosted and funded by the California Institute for Regenerative Medicine, the Stem Cell Bank in Novato will have 300 stem cell lines available immediately and will expand to 750 lines by February 2016. The repository will enable scientists to examine stem cells representing autism, epilepsy and other childhood neurological disorders; blinding eye diseases; heart, lung and liver diseases; Alzheimer’s disease, and relevant control samples. [Rainbow BioSciences] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW AABB Annual Meeting 2015
October 24-27, 2015
Anaheim, United States

NEW Clinical Applications of Stem Cells
February 24, 2016
Singapore, Singapore

Visit our events page to see a complete list of events in the mesenchymal cell community.
 
JOB OPPORTUNITIES
NEW Assistant Professor – Stem Cell Biology (University of South Carolina)

NEW Senior Stem Cell Scientist (Medicines and Healthcare Products Regulatory Agency)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Faculty Position – Life Sciences (Stowers Institute for Medical Research)

Faculty Positions – Stem Cells and Regenerative Medicine (King Abdullah University of Science and Technology)

Postdoctoral Fellow – Cardiovascular Stem Cell Biology and Tissue Engineering (Yale University)

Junior Group Leader – Cell and Development Biology Program (Centre for Genomic Regulation)

Professorship – Cellular and/or Molecular Biology and Immunology (Nanjing University)

Cell Biology Lab Manager (Harvard Apparatus Regenerative Technology)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)


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