Volume 7.38 | Sep 29

Mesenchymal Cell News 7.38 September 29, 2015
Mesenchymal Cell News
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Jagged-2 Enhances Immunomodulatory Activity in Adipose Derived Mesenchymal Stem Cells
Scientists investigated the immunomodulatory mechanisms of adipose derived mesenchymal stem cells (AMSCs) to better understand their immunogenic properties. Following 10 days of chondrogenic differentiation or 48 hours of IFN-γ pretreatment, AMSCs retained low level immunogenicity but prominent immunoregulatory activity and AMSC immunogenicity was enhanced by chondrogenic differentiation or IFN-γ treatment. [Sci Rep] Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Steric Interference of Adhesion Supports In Vitro Chondrogenesis of Mesenchymal Stem Cells on Hydrogels for Cartilage Repair
Researchers determined if a polyethylene glycol-modified fibrinogen matrix could support better chondrogenesis of human bone marrow mesenchymal stem cells based on steric interference of adhesion, when compared to a natural fibrin matrix. [Sci Rep] Full Article

Estrogen Receptor Mediates Simvastatin-Stimulated Osteogenic Effects in Bone Marrow Mesenchymal Stem Cells
Investigators hypothesized that the estrogen receptor (ER) mediates simvastatin-induced osteogenic differentiation. ER antagonists and siRNA were used to determine the involvement of the ER in simvastatin-induced osteogenesis in mouse bone marrow mesenchymal stem cells. [Biochem Pharmacol] Abstract

Preameloblast-Derived Factors Mediate Osteoblast Differentiation of Human Bone Marrow Mesenchymal Stem Cells via Runx2-Osterix-BSP Signaling
The authors investigated the effects of preameloblast-conditioned medium on human bone marrow mesenchymal stem cells in vitro, and investigated the bone regenerative capacity in vivo through epithelial-mesenchymal interactions of developmental osteogenesis. [Tissue Eng Part A] Abstract

In Vitro Migration and Proliferation (“Wound Healing”) Potential of Mesenchymal Stromal Cells Generated from Human CD271+ Bone Marrow Mononuclear Cells
The in vitro model of wound healing was used in order to compare the migration and proliferation potential of mesenchymal stromal cells (MSCs) generated from positively selected CD271+ bone marrow mononuclear cells and MSCs generated by plastic adherence of passage two and four cultured in presence or absence of growth factors or cytokines. [J Transl Med] Full Article

MicroRNA-498 Inhibition Enhances the Differentiation of Human Adipose-Derived Mesenchymal Stem Cells into Podocyte-Like Cells
The authors established a two-stage induction protocol for podocytes generation from human adipose-derived mesenchymal stem cells (hAD-MSCs). They initially established a condition that induce hAD-MSCs toward intermediate mesoderm cells with activin A and high concentration of RA. [Stem Cells Dev] Abstract

IL-21-Expressing Mesenchymal Stem Cells Prevent Lethal B-Cell Lymphoma through Efficient Delivery of IL-21, which Redirects the Immune System to Target the Tumor
The authors hypothesized that mesenchymal stem cells, genetically modified to express high levels of interleukin (IL)-21, can enhance anti-tumor responses through localized delivery of IL-21. [Stem Cells Dev] Abstract

Differential Osteogenic Potential of Human Adipose-Derived Stem Cells Co-Cultured with Human Osteoblasts on Polymeric Microfiber Scaffolds
The osteogenic potential of human adipose derived stem cells (HADSCs) co-cultured with human osteoblasts (HOBs) using selected HADSCs/HOBs ratios of 1:1, 2:1 and 1:2 respectively was evaluated. [J Biomed Mater Res A] Abstract

Mesenchymal Stromal Cells for Sphincter Regeneration: Role of Laminin Isoforms upon Myogenic Differentiation
The laminin family consists of 16 functionally different isoforms with LM-211 being the most abundant isoform of adult muscle tissues. All laminin isoforms tested showed a significant inhibition of the proliferation of undifferentiated mesenchymal stromal cells (MSCs) but, with the exception of LM-521, they had no influence on the proliferation of MSCs cultivated in myogenic medium. [PLoS One] Full Article

Disparate Effects of Mesenchymal Stem Cells in Experimental Autoimmune Encephalomyelitis and Cuprizone-Induced Demyelination
As the pathogeneses of multiple sclerosis and experimental autoimmune encephalomyelitis are thought to be mediated by IFNγ-producing and IL-17A-producing effector CD4+ T cells, scientists investigated the effect of mesenchymal stem cells on the development of these two key pathogenic cell groups. [PLoS One] Full Article

Mesenchymal Stem Cells of Different Origin: Comparative Evaluation of Proliferative Capacity, Telomere Length and Pluripotency Marker Expression
The authors characterized and compared proliferation, differentiation, telomere length and pluripotency marker expression in mesenchymal stem cells of various origins. [Life Sci] Abstract

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Multi-Lineage Differentiation of Mesenchymal Stem Cells – To Wnt, or not Wnt
The authors summarize the impact of Wnt signaling on multi-lineage differentiation of mesenchymal stem cells, and attempt to unravel the intricate interplay between Wnt and redox signals. [Int J Biochem Cell Biol] Abstract

Therapeutic Application of Mesenchymal Stem Cells in Osteoarthritis
The authors present a special focus on the types of extracellular vesicles that are produced by mesenchymal stem cells (MSCs) and their role in the paracrine activity of MSCs. They then discuss the therapeutic approaches that have been evaluated in pre-clinical models of osteoarthritis (OA) and the results coming out from the clinical trials in patients with OA. [Expert Opin Biol Ther] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
Lonza Improves Quality of Poietics™ Human MSCs by Expanding Characterization Criteria
Lonza has enhanced its range of Poietics™ Human Bone Marrow-Derived Mesenchymal Stem Cells (MSCs) by expanding the characterization of these cells to meet industry guidelines for translational and cell therapy research applications. [Lonza Group Ltd.] Press Release

Global Stem Cells Group, Inc. Announces Collaboration with VidaCel Laboratories and Stem Cell Bank, Chile
Global Stem Cells Group has announced a new collaboration with Santiago, Chile-based VidaCell Laboratories, Latin America’s oldest and largest cryopreserved umbilical cord cell bank. The alliance is focused on creating new protocols for cryopreservation of cord blood, cord tissue, adipose tissue and dental pulp stem cells, and the culture and expansion of cell colonies. [Global Stem Cells Group, Inc. (PRWeb)] Press Release

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Canadian Election Spotlights Scientists’ Frustrations
Canadians will head to the polls on October 19th, in a federal election that many scientists hope will mark a turning point after years of declining research budgets and allegations of government censorship. Although science has not emerged as a top issue during the campaign, researchers are fighting to make their concerns heard. [Nature News] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Keystone Symposia – Stem Cells and Cancer
March 6-10, 2016
Breckenridge, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Postdoctoral Researcher – Immune Response in Allo-Transplantation (NUI Galway)

Assistant Professor – Stem Cell Biology (University of South Carolina)

Senior Stem Cell Scientist (Medicines and Healthcare Products Regulatory Agency)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Faculty Position – Life Sciences (Stowers Institute for Medical Research)

Faculty Positions – Stem Cells and Regenerative Medicine (King Abdullah University of Science and Technology)

Postdoctoral Fellow – Cardiovascular Stem Cell Biology and Tissue Engineering (Yale University)

Junior Group Leader – Cell and Development Biology Program (Centre for Genomic Regulation)

Professorship – Cellular and/or Molecular Biology and Immunology (Nanjing University)

Cell Biology Lab Manager (Harvard Apparatus Regenerative Technology)

Postdoctoral Position – Stem Cells (Technion – Israel Institute of Technology)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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