Volume 7.40 | Oct 13

Mesenchymal Cell News 7.40 October 13, 2015
Mesenchymal Cell News
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Cell-Secreted Matrices Perpetuate the Bone-Forming Phenotype of Differentiated Mesenchymal Stem Cells
The authors examined the capacity of biomimetic decellularized extracellular matrices to preserve the mineral-producing phenotype upon withdrawal of the induction stimulus. Regardless of induction duration, ranging up to six weeks, mesenchymal stem/stromal cells exhibited up to a five-fold reduction in osteogenic markers within 24 hours following stimulus withdrawal. [Biomaterials] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Inhibition of Transforming Growth Factor-β Receptor Signaling Promotes Culture Expansion of Undifferentiated Human Endometrial Mesenchymal Stem/Stromal Cells
Scientists aimed to determine if A83-01, a TGF-β receptor inhibitor, prevents endometrial mesenchymal stem/stromal cells differentiation in culture. [Sci Rep] Full Article

Scaffold-Free, Human Mesenchymal Stem Cell-Based Tissue Engineered Blood Vessels
Hypothesizing that a scaffold-free tissue-engineered blood vessel may be advantageous, scientists constructed a tubular structure from aligned human mesenchymal cell sheets as the wall and human endothelial progenitor cell coating as the lumen. [Sci Rep] Full Article

Alleviation of Apoptosis of Bone Marrow-Derived Mesenchymal Stem Cells in the Acute Injured Kidney by Heme Oxygenase-1 Gene Modification
Acute kidney injury-kidney homogenate supernatant resulted in a high inhibitory rate of bone marrow-derived mesenchymal stem cells (BMSCs) growth and a high proportion of TUNEL positive BMSCs, while heme oxygenase-1 (HO-1) overexpression inversed this phenomenon and re-established the antioxidant and oxidant balance in HO-1-BMSCs. [Int J Biochem Cell Biol] Abstract

Role of Helicobacter pylori on Cancer of Human Adipose-Derived Mesenchymal Stem Cells and Metastasis of Tumor Cells — An In Vitro Study
The authors aimed to find the effects of H. pylori on human adipose-derived mesenchymal stem cells (MSCs) transforming toward cancer cells and also metastasis of tumor cells by synergic effects of H. pylori and gastric epithelial cells on MSCs. [Tumour Biol] Abstract

Roles of MicroRNA-34a Targeting SIRT1 in Mesenchymal Stem Cells
Scientists showed that microRNA-34a (miR-34a) was significantly up-regulated under hypoxia and serum deprivation conditions in mesenchymal stem cells, while overexpression of miR-34a was significantly associated with increased apoptosis, impaired cell vitality and aggravated senescence. [Stem Cell Res Ther] Full Article

Comparative Analysis of Human Mesenchymal Stem Cells Derived from Bone Marrow, Placenta and Adipose Tissue as Sources of Cell Therapy
Scientists characterized mesenchymal stem cells from different sources, including human bone marrow, placenta, and adipose tissue, in terms of the phenotype, surface antigen expression, differentiation ability, proteome reference map and blood flow recovery in a hindlimb ischemic disease model. [J Cell Biochem] Abstract

Microenvironmental Interaction between Hypoxia and Endothelial Cells Controls the Migration Ability of Placenta-Derived Mesenchymal Stem Cells via Alpha4 Integrin and Rho Signaling
Researchers compared the expression of markers related to integrin-mediated signaling in placenta-derived mesenchymal stem cells dependent on hypoxia and co-cultured with human umbilical vein endothelial cells and evaluated their correlations between migration ability and microenvironmental factors including hypoxia and endothelial cells. [J Cell Biochem] Abstract

Prospectively Defined Murine Mesenchymal Stem Cells Inhibit Klebsiella pneumoniae-Induced Acute Lung Injury and Improve Pneumonia Survival
Researchers demonstrated for the first time the feasibility and in vivo immunomodulatory capacity of prospectively defined mesenchymal stem cells in pneumonia. [Respir Res] Full Article

Bone Regeneration in Calvarial Defects in a Rat Model by Implantation of Human Bone Marrow-Derived Mesenchymal Stromal Cell Spheroids
The authors investigated bone regeneration in rats using the human bone marrow-derived mesenchymal stem cell-spheroids prepared by rotation culture, without synthetic or exogenous biomaterials. [J Mater Sci Mater Med] Full Article

Engraftability of Murine Bone Marrow-Derived Multipotent Mesenchymal Stem Cell Subpopulations in the Tissues of Developing Mice following Systemic Transplantation
Investigators generated single-cell subpopulations of mesenchymal stems cells from murine bone marrow and assessed them for differences in trafficking through the circulatory system and engraftment in bone and other tissues. [Cells Tissues Organs] Abstract

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Strategies to Improve the Immunosuppressive Properties of Human Mesenchymal Stem Cells
In this review, potential strategies to obtain mesenchymal stem cells with improved immunosuppressive properties and the potential roles of specific immunomodulatory genes, which are differentially upregulated in certain culture conditions, are discussed. [Stem Cell Res Ther] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Perinatal Stem Cell Society 2016
Nexxt Spine Announces Development of NanoMatrixx: A Porous Bioactive Titanium Material
Nexxt Spine, LLC, announced the development of NanoMatrixx, a porous bioactive titanium material designed to actively participate in the intervertebral fusion process. Following the manufacturing process, the material undergoes a series of proprietary treatments to produce a micro and nanosurface topography which stimulates mesenchymal stem cells to differentiate into bone forming osteoblast cells that produce bone growth onto and throughout the 3-D printed material. [Nexxt Spine, LLC (Business Wire)] Press Release

BrainStorm Announces Treatment of Final Patient in US Multicenter Double Blinded Phase II ALS Trial
BrainStorm Cell Therapeutics Inc. announced that the final patient has been treated in its multicenter Phase II clinical trial investigating the company’s proprietary NurOwn™ stem cell technology. [BrainStorm Cell Therapeutics Inc. (PR Newswire Association LLC)] Press Release

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European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Stem Cells: Development & Management
November 30-December 2, 2015
Phitsanulok, Thailand

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Postdoctoral Position – Stem Cell Biology (Odense University Hospital)

Postdoctoral Position – Bone Research (Weill Cornell College of Medicine)

Postdoctoral Position – Stem Cell Research (Karolinska Institute)

Assistant Professor – Stem Cell Biology (University of South Carolina)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Faculty Position – Life Sciences (Stowers Institute for Medical Research)

Faculty Positions – Stem Cells and Regenerative Medicine (King Abdullah University of Science and Technology)

Postdoctoral Fellow – Cardiovascular Stem Cell Biology and Tissue Engineering (Yale University)

Junior Group Leader – Cell and Development Biology Program (Centre for Genomic Regulation)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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