Volume 7.44 | Nov 10 - Mesenchymal Cell News

Mesenchymal Cell News 7.44 November 10, 2015

TOP STORY

The Immunosuppressive Signature of Menstrual Blood Mesenchymal Stem Cells Entails Opposite Effects on Experimental Arthritis and Graft versus Host Diseases
Scientists studied the immunosuppressive properties of MenSCs in comparison with well-characterized bone marrow derived-MSCs (BM-MSCs). Using in vitro proliferation assays, they showed that MenSCs displayed a lower suppressive effect on peripheral blood mononuclear cells and in particular on the proinflammatory CD4⁺IFN-γ⁺ and CD8⁺IFNγ⁺ cells than BM-MSCs. [Stem Cells] Abstract

Watch Video MesenTrek Rise of Enriched Mouse MSC Cultures

PUBLICATIONS (Ranked by impact factor of the journal)

IN VITRO

Changes in Autophagy, Proteasome Activity and Metabolism to Determine a Specific Signature for Acute and Chronic Senescent Mesenchymal Stromal Cells
Scientists induced mesenchymal stromal cell senescence by oxidative stress, doxorubicin treatment, X-ray irradiation and replicative exhaustion. The first three are considered inducers of acute senescence while extensive proliferation triggers replicative senescence also named as chronic senescence. [Oncotarget] Abstract

Multilayered Dense Collagen–Silk Fibroin Hybrid: A Platform for Mesenchymal Stem Cell Differentiation towards Chondrogenic and Osteogenic Lineages
Seeded mesenchymal stem cell-mediated dense collagen (DC)–silk fibroin (SF)–DC contraction, as well as growth and differentiation under chondrogenic and osteogenic supplements, were compared to those seeded in DC and on SF alone. [J Tissue Eng Regen Med] Abstract

Adipose-Derived Mesenchymal Stem Cells Prevent Systemic Bone Loss in Collagen-Induced Arthritis
The authors investigated the effect of adipose-derived MSCs (ASCs) on in vitro formation of bone-resorbing osteoclasts and pathological bone loss in the mouse collagen-induced arthritis model of rheumatoid arthritis. They observed that ASCs significantly inhibited receptor activator of NF-κB ligand–induced osteoclastogenesis in both a contact-dependent and -independent manner. [J Immunol] Abstract

The Murine Bladder Supports a Population of Stromal Sca-1⁺/CD34⁺/lin^– Mesenchymal Stem Cells
Scientists characterized a mesenchymal progenitor cell population as a first step in understanding its role in bladder fibrosis. Using fluorescence activated cell sorting, they identified a Sca-1⁺/CD34⁺/lin^– population in the adult murine bladder. [PLoS One] Full Article

Simulated Microgravity Inhibits Osteogenic Differentiation of Mesenchymal Stem Cells through Down Regulating the Transcriptional Co-Activator TAZ
The authors utilized a clinostat to model simulated microgravity (SMG) and found that SMG obviously inhibited osteogenic differentiation of rat bone marrow mesenchymal stem cells. They detected that SMG dramatically inhibited the expression of the transcriptional coactivator with PDZ-binding motif (TAZ), which acts as a vital regulator of osteogenesis. [Biochem Biophys Res Commun] Abstract

IN VIVO

Neuroprotection and Immunomodulation by Xenografted Human Mesenchymal Stem Cells following Spinal Cord Ventral Root Avulsion
Lewis rats were submitted to surgery for unilateral avulsion of the lumbar ventral roots and received 5×10⁵ adipose tissue mesenchymal stem cells via the lateral funiculus. Two weeks after cell administration, the animals were sacrificed and the motor neurons, T lymphocytes and cell defense nervous system were analyzed. [Sci Rep] Full Article

Safety of Allogeneic Bone Marrow Derived Mesenchymal Stromal Cell Therapy in Renal Transplant Recipients: The Neptune Study
This study will provide information on the safety of allogeneic mesenchymal stromal cells infusion and its effect on the incidence of biopsy proven acute rejection/graft loss. [J Transl Med] Full Article

Effects of In Vitro Endochondral Priming and Pre-Vascularisation of Human MSC Cellular Aggregates In Vivo
Researchers tested the hypothesis that a tissue regeneration approach that incorporates both chondrogenic priming of mesenchymal stem cells, to first form a cartilage template, and subsequent pre-vascularisation of the cartilage constructs, by co-culture with human umbilical vein endothelial cells in vitro, will improve vessel infiltration and thus mineral formation once implanted in vivo. [Stem Cell Res Ther] Full Article

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REVIEWS

Adipose Tissue-Derived Mesenchymal Stem Cells and Platelet-Rich Plasma: Stem Cell Transplantation Methods that Enhance Stemness
The authors describe the potential benefits of adding platelet-rich plasma (PRP) to adipose-derived mesenchymal stem cells (ASCs) and preclinical and clinical studies of this approach in various medical fields. They also discuss the mechanisms of PRP action and future cell-based therapies using co-transplantation of ASCs and PRP. [Stem Cell Res Ther] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

INDUSTRY NEWS

Cynata Engages CRO to Conduct GvHD Clinical Trial
Cynata Therapeutics Ltd announced that it has engaged The Clinical Trial Company Ltd. as the contract research organization for Cynata’s upcoming Phase I clinical study, which will investigate CYP-001 as a treatment for steroid-refractory graft versus host disease (GvHD). [Cynata Therapeutics Ltd] Press Release

Osiris Therapeutics Announces a New Product: Stravix™
Osiris Therapeutics, Inc. announced the launch of Stravix™, a cryopreserved human placental tissue designed to address surgical needs for soft tissue repair. [Osiris Therapeutics, Inc.] Press Release

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POLICY NEWS

Canada Creates Science-Minister Post
Canada’s new prime minister, Justin Trudeau, created the post of Minister of Science as one of his first acts. Kirsty Duncan, a medical geographer at the University of Toronto, will be the first to hold the job. [Nature News] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Gordon Research Conference – Craniofacial Morphogenesis & Tissue Regeneration
March 13-18, 2016
Ventura, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

NEW Faculty Positions – Stem Cell Biology (Albert Einstein College of Medicine)

NEW Research Technologist – Mesenchymal Stem Cell Biology (STEMCELL Technologies Inc.)

Research Associate – Stem Cells and Regenerative Medicine (King’s College London)

Research Technician II – Stem Cell and Gene Therapy (Fred Hutchinson Cancer Research Center)

Faculty Positions – Stem Cell Biology (University of Notre Dame)

Assistant or Associate Professor – Cell and Regenerative Biology (University of Wisconsin – Madison)

Postdoctoral Positions – Regenerative Biology and Medicine (Helmholtz Association)

Postdoctoral Fellowship – Developmental Cell Biology and Regenerative Medicine (University of California San Francisco)

Postdoctoral Position – Stem Cell Biology (Odense University Hospital)

Postdoctoral Position – Bone Research (Weill Cornell College of Medicine)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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