Volume 7.46 | Nov 24

Mesenchymal Cell News 7.46 November 24, 2015
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
New Approach to Help Bones Heal Faster and Better
Using bone samples from people undergoing hip replacement surgery, researchers were able to show that a new drug – a protein that activates a molecular pathway called the ‘Wnt’ pathway – causes stem cells found within bones to divide and to turn into more bone cells. [Press release from The University of Southampton discussing online publication in Stem Cell] Press Release | Video | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
IN VITRO

Cardiac Mesenchymal Stromal Cells Are a Source of Adipocytes in Arrhythmogenic Cardiomyopathy
The authors investigated whether cardiac mesenchymal stromal cells contributed to excess adipocytes in patients with arrhythmogenic cardiomyopathy (ACM). They found that, in ACM patients’ explanted heart sections, cells actively differentiating into adipocytes are of mesenchymal origin. [Eur Heart J] Full Article

Influence of Age on Rat Bone-Marrow Mesenchymal Stem Cells Potential
Six age groups from bone marrow mesenchymal stem cells of Wistar rats were studied (newborn, infant, young, pre-pubertal, pubertal and adult). Quantitative proteomic assay was performed by iTRAQ using an eight-plex iTRAQ labeling and the proteins differentially expressed were grouped in pluripotency, proliferative and metabolism processes. [Sci Rep] Full Article

Osteogenesis of Peripheral Blood Mesenchymal Stem Cells in Self Assembling Peptide Nanofiber for Healing Critical Size Calvarial Bony Defect
Peripheral blood mesenchymal stem cells (PBMSCs) were seeded into a nanofiber scaffold of self-assembling peptide (SAP) and cultured in osteogenic medium. The results indicated SAP can serve as a promising scaffold for PBMSCs survival and osteogenic differentiation in 3D conditions. [Sci Rep] Full Article

Early Passage Dependence of Mesenchymal Stem Cell Mechanics Influences Cellular Invasion and Migration
For clinical applicability during stem cell migration in vivo, scientists investigated the ability of human mesenchymal stem cells to invade into micropillar arrays of increasing confinement from 12 to 8 μm spacing between adjacent micropillars. [Ann Biomed Eng] Abstract

Protective Effects of HGF Gene-Expressing Human Mesenchymal Stem Cells in Acetaminophen-Treated Hepatocytes
The authors investigated the protective effect of hepatocyte growth factor (HGF) gene-transfected mesenchymal stem cells (MSCs) in acetaminophen-treated hepatocytes. They transfected the HGF gene into MSCs and confirmed HGF expression by RT-PCR and western blot. [Growth Factors] Abstract

CD4+ T Cells from Patients with Acute Myeloid Leukemia Inhibit the Proliferation of Bone Marrow-Derived Mesenchymal Stem Cells by Secretion of miR-10a
Through co-culturing CD4+ T cells from acute myeloid leukemia patients and bone marrow-derived mesenchymal stem cells (BM-MSCs) from healthy, investigators detected the proliferation of BM-MSCs from healthy by MTT assay. [J Cancer Res Clin Oncol] Abstract

IN VIVO

Tracking and Therapeutic Value of Human Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation in Reducing Venous Neointimal Hyperplasia Associated with Arteriovenous Fistula
Researchers aimed to determine if adventitial transplantation of human adipose tissue-derived mesenchymal stem cells to the outflow vein of B6.Cg-Foxn1nu/J mice with arteriovenous fistula at the time of creation would reduce monocyte chemoattractant protein-1 gene expression and venous neointimal hyperplasia. [Radiology] Abstract

PTH Induces Systemically Administered Mesenchymal Stem Cells to Migrate to and Regenerate Spine Injuries
Investigators evaluated the efficacy of combination intravenous mesenchymal stem cells and parathyroid hormone (PTH) therapy versus monotherapy and untreated controls, in a rat model of osteoporotic vertebral bone defects. [Mol Ther] Abstract

Mesenchymal Stem Cells and Cardiomyocytes Interplay to Prevent Myocardial Hypertrophy
Bone marrow-derived mesenchymal stem cells were indirectly cocultured with neonatal rat ventricular cardiomyocytes in vitro or intramyocardially transplanted into hypertrophic hearts in vivo. [Stem Cells Transl Med] Abstract

Propranolol and Mesenchymal Stromal Cells Combine to Treat Traumatic Brain Injury
Given the nonredundancy in their therapeutic mechanisms, investigators hypothesized that a combination of acute propranolol followed by mesenchymal stem cells isolated from human bone marrow would have additive effects in treating a rodent model of traumatic brain injury. [Stem Cells Transl Med] Abstract

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REVIEWS
Spheroid Mesenchymal Stem Cells and Mesenchymal Stem Cell-Derived Microvesicles: Two Potential Therapeutic Strategies
The characteristics, therapeutic applications and potential clinical translational opportunities of spheroid mesenchymal stem cells (MSCs) and MSC-microvesicles were discussed. [Stem Cells Dev] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Register for Clinical Applications of Stem Cells 2016
 
INDUSTRY NEWS
BioRestorative Therapies Granted Key Metabolic Patent
BioRestorative Therapies, Inc. announced the United States Patent and Trademark Office has issued a US patent covering methods related to BRT’s metabolic program. The patent allows for the protection of methods of production of generating stem cells and stem cell lines from brown adipose tissue under xeno-free conditions utilizing a proprietary differentiating medium. [BioRestorative Therapies, Inc.] Press Release

Nova Southeastern University Announces New NSU Cell Therapy Institute, an International Biomedical Research Collaboration with Scientists from the World-Renowned Karolinska Institutet
Nova Southeastern University (NSU) is at the forefront of conducting pioneering cell-based biomedical research with the launch of the new NSU Cell Therapy Institute, an international collaboration with prominent medical research scientists from Karolinska Institutet. [Nova Southeastern University (PR Newswire Association LLC)] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Keystone Symposium – Molecular and Cellular Basis of Growth and Regeneration
January 10-14, 2016
Breckenridge, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Adipose Stromal Cells (University of Texas Health Science Center at Houston)

NEW Postdoctoral Position – Organogenesis and Mesenchymal Stem Cells (University of Southern California)

Postdoctoral Fellows – Cardiovascular Biology and Regenerative Medicine (Icahn School of Medicine at Mount Sinai)

Faculty Positions – Stem Cell Biology (Albert Einstein College of Medicine)

Research Technician II – Stem Cell and Gene Therapy (Fred Hutchinson Cancer Research Center)

Assistant or Associate Professor – Cell and Regenerative Biology (University of Wisconsin – Madison)

Postdoctoral Positions – Regenerative Biology and Medicine (Helmholtz Association)

Postdoctoral Fellowship – Developmental Cell Biology and Regenerative Medicine (University of California San Francisco)

Postdoctoral Position – Bone Research (Weill Cornell College of Medicine)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)


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