Volume 7.49 | Dec 15

Mesenchymal Cell News 7.49 December 15, 2015
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Sepsis Induces Long-Term Metabolic and Mitochondrial Muscle Stem Cell Dysfunction Amenable by Mesenchymal Stem Cell Therapy
Researchers showed that mitochondrial and metabolic alterations underlie the sepsis-induced long-term impairment of satellite cells and lead to inefficient muscle regeneration. Engrafting mesenchymal stem cells improves the septic status by decreasing cytokine levels, restoring mitochondrial and metabolic function in satellite cells, and improving muscle strength. [Nat Commun] Full Article | Press Release
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PUBLICATIONS (Ranked by impact factor of the journal)
IN VITRO

Hypoxia Created Human Mesenchymal Stem Cell Sheet for Prevascularized 3D Tissue Construction
Scientists investigated the vascularization of human mesenchymal stem cell (hMSC) sheets under different oxygen tensions. They found that the HN condition, in which hMSC sheets formed under physiological hypoxia and then cocultured with endothelial cells under normoxia, enables longer and more branched microvessel network formation. [Adv Healthc Mater] Abstract

Simple Surface Engineering of Polydimethylsiloxane with Polydopamine for Stabilized Mesenchymal Stem Cell Adhesion and Multipotency
The authors aimed to tailor greener and biocompatible polydimethylsiloxane (PDMS) surfaces by developing a one-step bio-inspired polydopamine coating strategy to stabilize long-term bone marrow stromal cell culture on PDMS substrates. [Sci Rep] Full Article

Comparison of the Depolarization Response of Human Mesenchymal Stem Cells from Different Donors
Human mesenchymal stem cells from five donors were evaluated for their response to membrane potential depolarization. Scientists compared the inter-donor variability of their osteogenic and adipogenic differentiation potential, as well as their ability to maintain a differentiated phenotype after induction. [Sci Rep] Full Article

Genetic Modification of Human Mesenchymal Stem Cells Helps to Reduce Adiposity and Improve Glucose Tolerance in an Obese Diabetic Mouse Model
Researchers studied how high glucose (HG) exposure affects mesenchymal stem cells (MSCs) differentiation and whether the mechanism is reversible. They exposed human adipose tissue derived MSCs to HG and compared it to normal glucose exposed cells at 7, 10 and 14 days. [Stem Cell Res Ther] Full Article

Knockdown of SIRT6 Enables Human Bone Marrow Mesenchymal Stem Cell Senescence
Sirtuin 6 (SIRT6) expression increased with age while the proliferation and migration abilities of aged human bone marrow mesenchymal stem cells (BM-MSCs) were decreased compared with young cells. Knockdown of SIRT6 impaired the proliferative, migration, and oxidative stress resisting potentials of BM-MSCs. [Rejuvenation Res] Abstract

Collagen Promotes Higher Adhesion, Survival and Proliferation of Mesenchymal Stem Cells
Scientists studied the effect of extracellular matrix proteins in controlling cell survival, proliferation, migration and directed mesenchymal stem cell differentiation. They found that collagen promoted cell proliferation, cell survival under stress and promoted high cell adhesion to the cell culture surface. [PLoS One] Full Article

Evaluation of Cytocompatibility of Calcium Silicate-Based Endodontic Sealers and Their Effects on the Biological Responses of Mesenchymal Dental Stem Cells
Researchers investigated in vitro the cytocompatibility of the calcium silicate-containing endodontic sealers mineral trioxide aggregate Fillapex and TotalFill BC Sealer in human periodontal ligament stem cells by assaying their biological responses and compared them with that observed when using an epoxy resin-based sealer. [Int Endod J] Abstract

IN VIVO

A Distinct Subpopulation of Bone Marrow Mesenchymal Stem Cells, Muse Cells, Directly Commit to the Replacement of Liver Components
Bone marrow mesenchymal stem cells (BM-MSCs) have been suggested to contribute to liver regeneration but compose a heterogeneous population. Investigators generated a physical partial hepatectomy model in immunodeficient mice and injected green fluorescent protein-labeled human BM-MSC multilineage-differentiating stress-enduring (muse) cells intravenously. [Am J Transplant] Abstract

Effects of Mesenchymal Stem Cell Treatment on the Expression of Matrix Metalloproteinases and Angiogenesis during Ischemic Stroke Recovery
Scientists investigated the optimal time point of mesenchymal stem cell (MSC) transplantation. After MSC treatment, they also investigated the expression of matrix metalloproteinases, which play a role in vascular and tissue remodeling. [PLoS One] Full Article

Watch Video MesenTrek Rise of Enriched Mouse MSC Cultures
 
REVIEWS
Mesenchymal Stem Cells: Potential for Therapy and Treatment of Chronic Non-Healing Skin Wounds
Researchers provide an overview on the novel approaches through stem cell therapy to improve cutaneous wound healing, with a focus on diabetic wounds and systemic sclerosis-associated ulcers, which are particularly challenging. [Organogenesis] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

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INDUSTRY NEWS
Nohla Therapeutics Launches with Major US Cancer Research Institute Deal, Substantial Investment Round, and Key Appointments
Nohla Therapeutics Inc. announced the signing of an exclusive licensing and collaboration agreement with the Fred Hutchinson Cancer Research Center. [Nohla Therapeutics Inc. (Business Wire)] Press Release

Bone Therapeutics Completes Recruitment of the First Half of Patients in ALLOB® Phase IIA Spinal Fusion Trial
Bone Therapeutics announced it has successfully completed recruitment of the second cohort of four patients in its ALLOB® Phase IIA spinal fusion trial without any safety concerns. [Bone Therapeutics S.A.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW ICCSCE 2016: 18th International Conference on Cell and Stem Cell Engineering
September 15-16, 2016
Rome, Italy

Visit our events page to see a complete list of events in the mesenchymal cell community.
 
JOB OPPORTUNITIES
NEW Doctoral Fellow – Stem Cell Research (Uniklinik Koln)

NEW Postdoctoral Fellow – Stem Cell Biology/Genome Engineering (Amgen)

Postdoctoral Fellow – Therapy for Ischemic Heart Disease (University Health Network)

Postdoctoral Position – Heart Regenerative Medicine (Karolinska Institutet)

Postdoctoral Fellow – Cellular Genetic Programme (Wellcome Trust Sanger Institute)

Postdoctoral Position – Organogenesis and Mesenchymal Stem Cells (University of Southern California)

Postdoctoral Fellows – Cardiovascular Biology and Regenerative Medicine (Icahn School of Medicine at Mount Sinai)

Faculty Positions – Stem Cell Biology (Albert Einstein College of Medicine)

Assistant or Associate Professor – Cell and Regenerative Biology (University of Wisconsin – Madison)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)


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