Volume 8.01 | Jan 12

Mesenchymal Cell News 8.01 January 12, 2016
Mesenchymal Cell News
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Epac Activation Regulates Human Mesenchymal Stem Cells Migration and Adhesion
Researchers evaluated the role of exchange protein directly activated by cAMP (Epac) in the homing of human mesenchymal stem cells (hMSCs). They confirmed that hMSCs expressed functional Epac and its activation enhanced the migration and adhesion of hMSCs significantly. [Stem Cells] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

Adenosinergic Immunosuppression by Human Mesenchymal Stromal Cells (MSCs) Requires Co-operation with T Cells
Scientists demonstrated that adenosine is actively produced from adenosine 5′-monophosphate by CD73 on MSCs and MSC-derived extracellular vesicles. They indicated that although MSCs express CD39 at low level and it co-localizes with CD73 in bulge areas of membranes, the most efficient adenosine production from adenosine 5′-triphosphate requires co-operation of MSCs and activated T cells. [Stem Cells] Abstract

MiR-124 Promote Neurogenic Transdifferentiation of Adipose Derived Mesenchymal Stromal Cells Partly through RhoA/ROCK1, but Not ROCK2 Signaling Pathway
MiR-124 is significantly upregulated during neurogenic transdifferentiation of adipose derived mesenchymal stromal cells. Knockdown of endogenous miR-124 hampered neurogenic transdifferentiation and the acquired electrophysiological properties. [PLoS One] Full Article

Isolation and Localization of Mesenchymal Stem Cells in Human Palatine Tonsil by W5C5 (SUSD2)
This study investigated the expression of W5C5 in tonsil stromal cells and the colony-forming ability and differentiation potential of W5C5+ cells to determine the usefulness of W5C5+ MSCs as a marker that can be used for the purification of T-MSCs. [Cell Physiol Biochem] Full Article

Epigallocatechin-3-Gallate Protects against Tumor Necrosis Factor Alpha Induced Inhibition of Osteogenesis of Mesenchymal Stem Cells
Investigators examined the in vitro osteogenic differentiation of human mesenchymal stem cells. They found that the cell viability and osteoblast differentiation of human bone marrow-derived mesenchymal stem cells are significantly inhibited by inflammatory cytokine TNFα treatment. [Exp Biol Med] Abstract

Bilaminar Device of Poly(Lactic-co-Glycolic Acid)/Collagen Cultured with Adipose-Derived Stem Cells for Dermal Regeneration
Researchers developed and characterized a new device consisting of poly(lactic-co-glycolic acid) and collagen associated with mesenchymal stem cells derived from human adipose tissue. [Artif Organs] Abstract


Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients with Amyotrophic Lateral Sclerosis: Results of Phase I/II and IIa Clinical Trials
Investigators determined the safety and possible clinical efficacy of autologous mesenchymal stem cell-neurotrophic growth factor cells transplantation in patients with amyotrophic lateral sclerosis. [JAMA Neurol] Abstract | Press Release

Intracoronary Transplantation of Mesenchymal Stem Cells with Overexpressed Integrin-Linked Kinase Improves Cardiac Function in Porcine Myocardial Infarction
Scientists engineered mesenchymal stem cells (MSCs) with integrin-linked kinase, a pleiotropic protein critically regulating cell survival, proliferation, differentiation, and angiogenesis. They combined ferumoxytol with poly-L-lysine, and found this combination promisingly enabled MRI visualization of MSCs in vitro and in vivo with good safety. [Sci Rep] Full Article

Combination of Controllably Released Platelet Rich Plasma Alginate Beads and Bone Morphogenic Protein-2 Gene-Modified Mesenchymal Stem Cells for Bone Regeneration
The authors studied the combined effect of sustained released platelet rich plasma (PRP) from alginate beads on bone morphogenic protein-2 modified mesenchymal stem cells osteogenic differentiation in vitro and of sustained PRP alone on a fracture defect model ex vivo as well as its effect on the calvarial suture closure. [J Periodontol] Abstract

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Non-Viral Approaches for Direct Conversion into Mesenchymal Cell Types: Potential Application in Tissue Engineering
The authors discuss the recent progress in direct conversion technologies, specifically focusing on generating mesenchymal cell types. [J Biomed Mater Res B Appl Biomater] Abstract

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Announcement of Collaboration between Healios and Athersys for Regenerative Medicine Products Marketed in Japan using MultiStem® Cell Therapy and Fund Borrowing by Healios
Healios K.K. and Athersys, Inc. have announced a partnership and license agreement for the development of regenerative medicine products that will be developed and marketed in Japan by Healios, making use of Athersys’ proprietary, patented stem cell product, MultiStem® cell therapy. [Healios K.K.] Press Release

Launch of Phase I Clinical Trial for AlloJoin Off-the-Shelf Allogeneic Stem Cell Therapy for KOA
Cellular Biomedicine Group Inc. announced the launch of a Phase I clinical trial of an off-the-shelf allogeneic adipose-derived mesenchymal progenitor cell AlloJoin™ therapy for knee osteoarthritis (KOA). [Cellular Biomedicine Group Inc.] Press Release

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NEW ICSCRM 2016: 18th International Conference on Stem Cells and Regenerative Medicine
February 25-26, 2016
London, United Kingdom

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NEW Development Engineer/Scientist – Cell and Gene Therapy and Regenerative Medicine (Centre for Commercialization of Regenerative Medicine)

NEW Project Manager – Neurodegeneration and Stem Cell Science (Université du Luxembourg)

NEW Postdoctoral Research Associate – Developmental and Stem Cell Biology (University of Cambridge)

Postdoctoral Fellow – Cell Therapy (Toronto Western Hospital)

Stem Cell Scientist and Postdoctoral Positions (National Center for Advancing Translational Science)

PhD Studentship – Aging Research (Cologne Graduate School of Aging Research)

Doctoral Fellow – Stem Cell Research (Uniklinik Koln)

Postdoctoral Fellow – Stem Cell Biology/Genome Engineering (Amgen)

Postdoctoral Fellow – Therapy for Ischemic Heart Disease (University Health Network)

Postdoctoral Position – Organogenesis and Mesenchymal Stem Cells (University of Southern California)

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