Volume 8.04 | Feb 2

Mesenchymal Cell News 8.04 February 2, 2016
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Scientists Discover Stem Cells Capable of Repairing Skull, Face Bones
Scientists have, for the first time, identified and isolated a stem cell population capable of skull formation and craniofacial bone repair in mice—achieving an important step toward using stem cells for bone reconstruction of the face and head in the future. [Press release from University of Rochester Medical Center discussing online prepublication in Nature Communications] Press Release | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
IN VITRO

Up-Regulation of Immunomodulatory Effects of Mouse Bone-Marrow Derived Mesenchymal Stem Cells by Tetrahydrocannabinol Pre-Treatment Involving Cannabinoid Receptor CB2
Scientists found that tetrahydrocannabinol activated cannabinoid receptor type 2 (CB2) receptor and ERK signaling, consequently enhancing the modulation of mesenchymal stem cells on inflammation-associated cytokine release from lipopolysaccharides-stimulated microglia. [Oncotarget] Full Article

Alginate-Encapsulation for the Improved Hypothermic Preservation of Human Adipose-Derived Stem Cells
Researchers examined whether hypothermic preservation of human adipose-derived stem cells could be improved through their encapsulation in 1.2% calcium alginate. Alginate encapsulation improved the recovery of viable cells after 72 hours of storage. [Stem Cells Transl Med] Abstract | Press Release

MicroRNA-27b Enhances the Hepatic Regenerative Properties of Adipose-Derived Mesenchymal Stem Cells
Scientists investigated the mechanistic role of how miR-27b modulated regenerative capacities of adipose-derived mesenchymal stem cells (ASCs). Intravenous administration of miR-27b-transfected ASCs was conducted after 70% partial hepatectomy. [Mol Ther Nucleic Acids] Full Article

A Systematic Study of the Effect of Different Molecular Weights of Hyaluronic Acid on Mesenchymal Stromal Cell-Mediated Immunomodulation
Mesenchymal stromal cells (MSCs) are often delivered with hyaluronic acid (HA), although the combined mechanism of action is not fully understood; the authors thus investigated the immunomodulatory effects of combining MSCs with different molecular weights of HA. [PLoS One] Full Article

BPA-Toxicity via Superoxide Anion Overload and a Deficit in β-Catenin Signaling in Human Bone Mesenchymal Stem Cells
Bisphenol A (BPA) increased cytotoxicity in human bone mesenchymal stem cells in a dose- and time-dependent manner, concomitantly with increased lipid peroxidation. [Environ Toxicol] Abstract

IN VIVO

Soluble Tumor Necrosis Factor Receptor 1 Released by Skin-Derived Mesenchymal Stem Cells Is Critical for Inhibiting Th17 Cell Differentiation
Investigators demonstrated that the intraperitoneal administration of skin-derived mesenchymal stem cells substantially ameliorated the development of experimental autoimmune encephalomyeliti in mice. [Stem Cells Transl Med] Abstract

Wnt11 Plays an Important Role in the Osteogenesis of Human Mesenchymal Stem Cells in a PHA/FN/ALG Composite Scaffold: Possible Treatment for Infected Bone Defect
Tissue-engineered bone was constructed with human mesenchymal stem cells and porous hydroxyapatite/fibronectin/alginate (PHA/FN/ALG) composite scaffolds, and then was implanted into an infected bone defect model for evaluating the osteogenic capacity by quantitative PCR, gross observation, micro-CT and histology analysis. [Stem Cell Res Ther] Full Article

TOB1 Deficiency Enhances the Effect of Bone Marrow-Derived Mesenchymal Stem Cells on Tendon-Bone Healing in a Rat Rotator Cuff Repair Model
The authors investigated the effect of silencing TOB1 (Transducer of ERBB2, 1) expression in bone marrow-derived mesenchymal stem cells (MSCs) on MSC-facilitated tendon-bone healing in a rat supraspinatus repair model. [Cell Physiol Biochem] Full Article

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REVIEWS
Differentiation of Mesenchymal Stem Cells for Cartilage Tissue Engineering: Individual and Synergetic Effects of Three-Dimensional Environment and Mechanical Loading
The authors provide an insight into the interplay between external loading program and scaffold properties during chondrogenic differentiation. [Acta Biomater] Abstract

Mesenchymal Stem Cells and Alginate Microcarriers for Craniofacial Bone Tissue Engineering: A Review
Researchers explore the potential use of alginate microcarrier for stem cell systems and its application in craniofacial bone tissue engineering. [J Biomed Mater Res A] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

ASGCT 2016 Annual Meeting
 
INDUSTRY NEWS
Stemedica Cell Technologies Announces Completion of Enrollment in Phase I/IIa Clinical Trial for Ischemic Stroke
Stemedica Cell Technologies, Inc. announced completion of enrollment into “A Phase I/IIa, Multi-Center, Open-Label Study to Assess the Safety, Tolerability, and Preliminary Efficacy of a Single Intravenous Dose of Allogeneic Mesenchymal Bone Marrow Cells to Subjects with Ischemic Stroke.” [Stemedica Cell Technologies, Inc.] Press Release

NUI Galway Launch €6 Million Robotic Stem Cell Production Project
NUI Galway’s Regenerative Medicine Institute has launched a new €6 million research project AUTOSTEM to develop pioneering manufacturing systems for stem cell therapy. Funded by the EU Horizon 2020 program, AUTOSTEM will go a long way towards meeting the demand for these new treatments, by transforming the way stem cells are manufactured. [National University of Ireland (NUI), Galway] Press Release

DKK 60 Million Awarded for Four Interdisciplinary Research Projects
The Novo Nordisk Foundation has awarded grants for four interdisciplinary research projects under the Interdisciplinary Synergy Program. Each project receives up to DKK 15 million per year for three years. [Novo Nordisk Foundation] Press Release

Cynata Receives Favourable Advice from UK Regulatory Authority
The UK Medicines and Healthcare products Regulatory Agency confirmed that Cynata’s proprietary Cymerus™ mesenchymal stem cell product, CYP-001, is considered to be suitable for use in a proposed Phase I clinical trial in patients with graft versus host disease. [Cynata Therapeutics Ltd] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW World Stem Cells & Regenerative Medicine Congress
May 18-20, 2016
London, United Kingdom

Visit our events page to see a complete list of events in the mesenchymal cell community.
 
JOB OPPORTUNITIES
NEW Research Assistant – Cancer Research (NUI Galway)

Project Scientist – Pulmonary Research (Cedars Sinai Medical Center)

Tenure-Track Faculty Positions – Assistant/Associate/Full Professor (Nanyang Technological University)

Development Engineer/Scientist – Cell and Gene Therapy and Regenerative Medicine (Centre for Commercialization of Regenerative Medicine)

Project Manager – Neurodegeneration and Stem Cell Science (Université du Luxembourg)

Postdoctoral Research Associate – Developmental and Stem Cell Biology (University of Cambridge)

Postdoctoral Fellow – Cell Therapy (Toronto Western Hospital)

Stem Cell Scientist and Postdoctoral Positions (National Center for Advancing Translational Science)

PhD Studentship – Aging Research (Cologne Graduate School of Aging Research)

Doctoral Fellow – Stem Cell Research (Uniklinik Koln)

Postdoctoral Fellow – Stem Cell Biology/Genome Engineering (Amgen)


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