Volume 8.12 | Mar 29

Mesenchymal Cell News 8.12 March 29, 2016
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow
To test whether leptin receptor (LepR) regulates skeletal stem cell function, the authors conditionally deleted Lepr from limb bone marrow stromal cells, but not from the axial skeleton or hypothalamic neurons, using Prx1-Cre. [Cell Stem Cell] Abstract | Graphical Abstract
MesenPure™: Highly Enriched Mouse MSC Cultures As Early As Passage 0! Watch this video to learn more.
 
PUBLICATIONS (Ranked by impact factor of the journal)
IN VITRO

Mesenchymal Stromal Cells Induce Peculiar Alternatively Activated Macrophages Capable of Dampening Both Innate and Adaptive Immune Responses
Researchers showed that mesenchymal stromal cells (MSCs) supported the survival of monocytes that underwent differentiation into macrophages, in the presence of macrophage colony-stimulating factor. However, MSCs skewed their polarization towards a peculiar M2-like functional phenotype, through a prostaglandin E2-dependent mechanism. [Stem Cells] Abstract | Full Article

Hedgehog Associated to Microparticles Inhibits Adipocyte Differentiation via a Non-Canonical Pathway
Investigators showed that Hedgehog-enriched microparticles inhibit adipocyte differentiation and orientate mesenchymal stem cells towards a pro-osteogenic program. [Sci Rep] Full Article

NAP-2 Secreted by Human NK Cells Can Stimulate Mesenchymal Stem/Stromal Cell Recruitment
Strategies for improved homing of mesenchymal stem cells (MSCs) to a place of injury are being sought and it has been shown that natural killer (NK) cells can stimulate MSC recruitment. Researchers studied the chemokines behind this recruitment. Assays were performed with bone marrow human MSCs and NK cells freshly isolated from healthy donor buffy coats. [Stem Cell Reports] Full Article | Graphical Abstract

Wnt/β-Catenin Stimulation and Laminins Support Cardiovascular Cell Progenitor Expansion from Human Fetal Cardiac Mesenchymal Stromal Cells
Scientists demonstrated that they can expand cells with characteristics of cardiovascular progenitor cells from the mesenchymal stromal cell population of human fetal hearts. [Stem Cell Reports]
Full Article | Graphical Abstract

Soft Elasticity-Associated Signaling and Bone Morphogenic Protein 2 Are Key Regulators of Mesenchymal Stem Cell Spheroidal Aggregates
Researchers hypothesized that bone morphogenic protein 2 (BMP2) signaling triggers interleukin-1 (IL-1) signaling in mesenchymal stem cell spheroids. Contrary to expectations, BMP2 signaling decreased expression of IL1B and downstream genes in a SMAD6-dependent manner. [Stem Cells Dev] Abstract

Human Mesenchymal Stromal Cells Response to Biomimetic Octacalcium Phosphate Containing Strontium
Scientists demonstrated the effects of Sr2+ on the osteogenic differentiation of human mesenchymal stromal cells when introduced as either a dissolved salt, or incorporated into biomimetic calcium phosphate coatings. [J Biomed Mater Res A] Abstract

Chondrogenic Differentiation of Mesenchymal Stem Cells on Glycosaminoglycan-Mimetic Peptide Nanofibers
Mesenchymal stem cells cultured on glycosaminoglycan (GAG)-mimetic peptide nanofibers formed cartilage-like nodules and deposited cartilage-specific matrix components by day seven, suggesting that the GAG-mimetic peptide nanofibers effectively facilitated their commitment into the chondrogenic lineage. [ACS Biomater Sci Eng] Abstract

IN VIVO

Human Mesenchymal Stem Cells Genetically Engineered to Overexpress Brain-Derived Neurotrophic Factor Improve Outcomes in Huntington’s Disease Mouse Models
Previous studies have shown efficacy of mesenchymal stem/stromal cells (MSC)/brain-derived neurotrophic factor (BDNF) using murine MSCs, and here scientists used human MSCs to advance the therapeutic potential of the MSC/BDNF platform for clinical application. [Mol Ther] Full Article | Press Release

Muscle Tissue Engineering Using Gingival Mesenchymal Stem Cells Encapsulated in Alginate Hydrogels Containing Multiple Growth Factors
The authors developed an injectable 3D RGD-coupled alginate scaffold with multiple growth factor delivery capacity for encapsulating gingival mesenchymal stem cells (GMSCs), evaluated the capacity of encapsulated GMSCs to differentiate into myogenic tissue in vitro and in vivo where encapsulated GMSCs were transplanted subcutaneously into immunocompromised mice. [Ann Biomed Eng] Full Article

Request Your Free Wallchart: Mesenchymal Stem Cells (A Nature Reviews Molecular Cell Biology Collaboration)
 
REVIEWS
Mesenchymal Stem Cell Derived Secretome and Extracellular Vesicles for Acute Lung Injury and Other Inflammatory Lung Diseases
The authors summarize the preclinical studies testing mesenchymal stem or stromal cell (MSC) conditioned medium and/or MSC extracellular vesicles as treatment for acute lung injury and other inflammatory lung diseases. [Expert Opin Biol Ther] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Register for Cord Blood Symposium 2016
 
INDUSTRY NEWS
BioLineRx Announces Initiation of Phase II Trial for BL-8040 as Novel Stem Cell Mobilization Treatment
BioLineRx Ltd. announced the initiation of a Phase II trial for BL-8040 as a novel approach for the mobilization and collection of bone marrow stem cells from the peripheral blood circulation. [BioLineRx Ltd.] Press Release

Three ERC-Grants for Research Groups at the Vienna Biocenter
Jan-Michael Peters and Tim Clausen of the Research Institute of Molecular Pathology and Jürgen Knoblich of the Institute of Molecular Biotechnology each received an Advanced Grant by the European Research Council (ERC). [Institute of Molecular Pathology] Press Release

From our sponsor:
Learn about mucociliary differentiation of primary bronchial epithelial cells.
Watch the video.
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Cell Symposia – 10 Years of iPSCs
September 25-27, 2016
Berkeley, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Research Associate – Stem Cell Biology and Cell Differentiation (University of Illinois Chicago College of Medicine)

Research Technologist – Mesenchymal Stem Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Position – Epigenetic Regulation of Cell Fate, Cancer and Metabolism (University Medical Center Freiburg)

Postdoctoral Fellow – Mechanoregulation of Fibrosis and Vascular Injury (St. Michael’s Hospital)

Cell Culture Technician (California Institute of Technology)

Postdoctoral Positions – Human Stem Cells and Heart Regenerative Medicine (University of Pittsburgh)

Postdoctoral Positions – Tissue Repair/Inflammation (Institut Pasteur)

Two Early Stage Researchers/PhD Fellowships – Tendon Therapy (NUI Galway)

Postdoctoral Position – Organogenesis and Mesenchymal Stem Cells (University of Southern California)

Non-Tenure Track Assistant/Associate Professor – Regenerative Medicine (The University of Hong Kong – Karolinska Institutet Collaboration in Regenerative Medicine)

Independent Group Leaders – Regenerative Medicine (Center of Regenerative Medicine in Barcelona)

Tenure-Track Faculty Positions – Assistant/Associate/Full Professor (Nanyang Technological University)


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