Volume 8.13 | Apr 5

Mesenchymal Cell News 8.13 April 5, 2016
Mesenchymal Cell News
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Mediator MED23 Cooperates with RUNX2 to Drive Osteoblast Differentiation and Bone Development
Investigators report that the mediator subunit MED23 cooperates with RUNX2 to regulate osteoblast differentiation and bone development. Med23 deletion in mesenchymal stem cells or osteoblast precursors resulted in multiple bone defects similar to those observed in Runx2+/− mice. [Nat Commun] Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)

Purinergic and Store-Operated Ca2+ Signaling Mechanisms in Mesenchymal Stem Cells and Their Roles in ATP-Induced Stimulation of Cell Migration
Scientists investigated the molecular mechanisms underlying ATP-induced Ca2+ signaling and their roles in the regulation of cell migration in human dental pulp mesenchymal stem cells. [Stem Cells] Abstract

Tissue-Specific Differentiation Potency of Mesenchymal Stromal Cells from Perinatal Tissues
The authors successfully isolated and cultured mesenchymal stromal cells from amnion (AMSCs), chorion, and umbilical cord. Proliferation potential was different among them, that AMSCs revealed the lowest proliferation rate due to increased Annexin V and senescence-associated β-galactosidase positive cells. [Sci Rep] Full Article

A20 Plays a Critical Role in the Immunoregulatory Function of Mesenchymal Stem Cells
Investigators provided new information to partly explain the molecular mechanisms of immunoregulation by mesenchymal stem cells (MSCs). Specifically, they found that A20 expression was induced in MSCs by inflammatory cytokines. [J Cell Mol Med] Full Article

Prospective Purification of Perivascular Presumptive Mesenchymal Stem Cells from Human Adipose Tissue: Process Optimization and Cell Population Metrics across a Large Cohort of Diverse Demographics
Researchers described an optimized protocol that aims to deliver pure, viable and consistent yields of perivascular stem cells (PSC) from adipose tissue. They analyzed the frequency of PSC within adipose tissue, and the effect of patient and procedure based variables on this yield. [Stem Cell Res Ther] Full Article

Effect of miR-26a-5p on the Wnt/Ca2+ Pathway and Osteogenic Differentiation of Mouse Adipose-Derived Mesenchymal Stem Cells
Investigators examined the role of miR-26a-5p in the regulation of osteogenic differentiation of mouse adipose-derived mesenchymal stem cells by using mimics and inhibitors of this microRNA. They showed that over-expression of miR-26a-5p inhibited osteogenesis and that suppression of endogenous miR-26a-5p promoted osteogenesis. [Calcif Tissue Int] Abstract

α2-6Sialylation Is a Marker of the Differentiation Potential of Human Mesenchymal Stem Cells
Researchers used lectin microarray technology to identify cell surface glycans as markers of the differentiation potential of stem cells. They found that α2-6Sia-specific lectins showed stronger binding to early passage adipose-derived human mesenchymal stem cells than late passage cells. [Glycobiology] Abstract

Hypoxia Enhances Tenocyte Differentiation of Adipose-Derived Mesenchymal Stem Cells by Inducing Hypoxia-Inducible Factor-1α in a Co-Culture System
Scientists investigated effects of O2 tension and potential signaling pathways on adipose-derived mesenchymal stem cells differentiation into tenocytes, in an indirect co-culture system. [Cell Prolif] Abstract


Mitochondrial Transfer via Tunneling Nanotubes (TNT) is an Important Mechanism by which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS
The authors investigated the hypothesis that the anti-microbial effect of mesenchymal stromal cells in vivo depends on their modulation of macrophage phagocytic activity which occurs through mitochondrial transfer. [Stem Cells] Abstract

Icariin Attenuates Titanium-Particle Inhibition of Bone Formation by Activating the Wnt/β-Catenin Signaling Pathway In Vivo and In Vitro
Researchers demonstrated that icariin significantly attenuated titanium-particle inhibition of osteogenic differentiation of mesenchymal stem cells. Additionally, icariin increased bone mass and decreased bone loss in titanium-particle-induced osteolytic sites. [Sci Rep] Full Article

Human Embryonic Stem Cell-Derived Mesenchymal Stromal Cells Ameliorate Collagen-Induced Arthritis by Inducing Host-Derived Indoleamine 2,3 Dioxygenase
Scientists tested the therapeutic potential of human pluripotent stem cell-mesenchymal stromal cells (hPSC-MSC) of embryonic origin in the experimental model of collagen-induced arthritis. Mice were treated with either a single dose of hESC-MSC on the day of immunization or with three doses of hESC-MSC every other day starting on the day of arthritis onset. [Arthritis Res Ther] Full Article

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Graphene-Based Materials for Tissue Engineering
The authors highlight the recent applications of graphene-based materials in tissue engineering and regenerative medicine. In particular, they discuss the application of graphene-based materials in cardiac, neural, bone, cartilage, skeletal muscle, and skin/adipose tissue engineering. [Adv Drug Deliv Rev]
Abstract | Graphical Abstract

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Heart Failure Patients Have Improved Outcomes following Investigational Stem Cell Treatment
An investigational stem cell therapy derived from patients’ own blood marrow significantly improved outcomes in patients with severe heart failure. [Press release from Cedars-Sinai Heart Institute (EurekAlert!) discussing research presented at the 65th Annual Scientific Session & Expo of the American College of Cardiology (ACC.16), Chicago] Press Release

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Griffith Uses 3D Tissue Engineering to Revolutionize Dental Disease
The discomfort and stigma of loose or missing teeth could be a thing of the past as Griffith University researchers pioneer the use of 3D bioprinting to replace missing teeth and bone. The three-year study, which has been granted a National Health and Medical Research Council Grant of $650,000, is being undertaken by periodontist Professor Saso Ivanovski from Griffith’s Menzies Health Institute Queensland. [Griffith University] Press Release

Bone Therapeutics Reports Initial Efficacy Results from Its PREOB® Phase IIA Trial in Severe Osteoporosis
Bone Therapeutics announced the 12-month efficacy results from the first cohort of seven patients treated with PREOB® in its Phase IIA severe osteoporosis trial. [Bone Therapeutics S.A.] Press Release
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NEW From Stem Cells to Human Development
September 25-28, 2016
Southbridge, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Postdoctoral Training Fellow – Molecular and Stem Cell Biology (The Francis Crick Institute)

Research Technologist – Mesenchymal Stem Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Research Associate – Stem Cell Biology and Cell Differentiation (University of Illinois Chicago College of Medicine)

Postdoctoral Position – Epigenetic Regulation of Cell Fate, Cancer and Metabolism (University Medical Center Freiburg)

Postdoctoral Fellow – Mechanoregulation of Fibrosis and Vascular Injury (St. Michael’s Hospital)

Cell Culture Technician (California Institute of Technology)

Postdoctoral Positions – Tissue Repair/Inflammation (Institut Pasteur)

Two Early Stage Researchers/PhD Fellowships – Tendon Therapy (NUI Galway)

Postdoctoral Position – Organogenesis and Mesenchymal Stem Cells (University of Southern California)

Independent Group Leaders – Regenerative Medicine (Center of Regenerative Medicine in Barcelona)

Tenure-Track Faculty Positions – Assistant/Associate/Full Professor (Nanyang Technological University)

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