Volume 8.16 | Apr 26

Mesenchymal Cell News 8.16 April 26, 2016
Mesenchymal Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Type I Interferons Exert Anti-Tumor Effect via Reversing Immunosuppression Mediated by Mesenchymal Stromal Cells
Researchers found that interferon alpha (IFNα)-secreting mesenchymal stromal cells (MSCs) showed more dramatic inhibition effect on tumor progression than that of IFNα alone. Interestingly, IFNα-primed MSCs could also effectively suppress tumor growth. Mechanistically, they demonstrated that both IFNα and IFNβ reversed the immunosuppressive effect of MSCs on splenocyte proliferation. [Oncogene] Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
IN VITRO

Comparative miRNA-Based Fingerprinting Reveals Biological Differences in Human Olfactory Mucosa- and Bone-Marrow-Derived Mesenchymal Stromal Cells
The lower expression of miR-140-5p in olfactory mucosa-mesenchymal stromal cells (MSCs) correlated with higher secretion of CXCL12 compared with bone-marrow-MSCs. [Stem Cell Reports]
Full Article | Graphical Abstract

Enhanced Tenogenic Differentiation and Tendon-Like Tissue Formation by Tenomodulin Overexpression in Murine Mesenchymal Stem Cells
Scientists investigated the effect of tenomodulin overexpression on tenogenic differentiation of murine mesenchymal stem cells via plasmid-mediated overexpression in the C3H10T1/2 cell line. [J Tissue Eng Regen Med] Abstract

Polycomb Protein BMI1 Regulates Osteogenic Differentiation of Human Adipose Tissue-Derived Mesenchymal Stem Cells Downstream of GSK3
Researchers studied the role of B lymphoma Mo-MLV insertion region 1 homolog (BMI1) in the osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells (hASCs). BMI1 protein but not RNA levels increased during in vitro osteogenic differentiation of hASCs. [Stem Cells Dev] Abstract

MicroRNA-206 Is Involved in Survival of Hypoxia Preconditioned Mesenchymal Stem Cells through Targeting Pim-1 Kinase
Investigators proposed that hypoxic preconditioning could increase survival of bone marrow mesenchymal stem cells via upregulation of Pim-1 and aimed to determine the microRNAs that modulate the expression of Pim-1. [Stem Cell Res Ther] Full Article

Single Cell Imaging to Probe Mesenchymal Stem Cell N-Cadherin Mediated Signaling within Hydrogels
Investigators utilized confocal imaging to investigate the influence of N-cadherin interactions on single mesenchymal stem cell behavior within 3-dimensional hydrogel environments under conditions that promote chondrogenic differentiation. [Ann Biomed Eng] Abstract

Decreased Osteogenesis in Mesenchymal Stem Cells Derived from the Aged Mouse Is Associated with Enhanced NF-κB Activity
Bone marrow-mesenchymal stem cells (MSCs) were isolated from young and aged mice. NF-κB activity in MSCs at basal levels and under different biological conditions were determined by the authors’ recently established lentiviral vector-based luciferase reporter assay. [J Orthop Res] Abstract

CD105 Promotes Chondrogenesis of Synovium-Derived Mesenchymal Stem Cells through Smad2 Signaling
Scientists observed a considerable heterogeneity with respect to CD105 expression among mesenchymal stem cells (MSCs) isolated from synovium. The CD105+ and CD105 synovium-derived MSCs were sorted to compare their differentiation capacities and relative gene expressions [Biochem Biophys Res Commun] Abstract

IN VIVO

Bone Marrow-Derived Mesenchymal Stem Cells Improve Diabetes-Induced Cognitive Impairment by Exosome Transfer into Damaged Neurons and Astrocytes
The authors showed that rat bone marrow mesenchymal stem cells (BM-MSCs) can improve the cognitive impairments of STZ-diabetic mice by repairing damaged neurons and astrocytes. The Morris water maze test demonstrated that cognitive impairments induced by diabetes were significantly improved by intravenous injection of BM-MSCs. [Sci Rep] Full Article

Comparison of Adipose-Derived and Bone Marrow Mesenchymal Stromal Cells in a Murine Model of Crohn’s Disease
Researchers investigated the therapeutic effect of adipose-derived mesenchymal stromal cells (AD-MSCs) and to compare the therapeutic effect of AD-MSCs with that of bone marrow MSCs in a murine model of Crohn’s disease. [Dig Dis Sci] Abstract

Local Injection of Bone Mesenchymal Stem Cells and Fibrin Glue Promotes the Repair of Bone Atrophic Nonunion In Vivo
Scientists evaluated the efficacy of local injection of bone mesenchymal stem cells and fibrin glue in the treatment of atrophic nonunion in an animal model. [Adv Ther] Abstract

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REVIEWS
hiPSC-Derived iMSCs: NextGen MSCs as an Advanced Therapeutically Active Cell Resource for Regenerative Medicine
The role of induced pluripotent stem cell-derived mesenchymal stromal cells (iMSCs) as an alternate source of therapeutically active MSCs has been described. Additionally, the role of iMSCs in regenerative medical applications, the necessary strategies, and the regulatory policies that have to be enforced to render iMSC’s effectiveness in translational medicine is discussed. [J Cell Mol Med] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
 
INDUSTRY NEWS
Researcher Receives NIH Grant to Continue Development of New Therapeutic Agents for Multiple Sclerosis, Cancer and Sepsis
A leading scientist at Florida Atlantic University has received $540,250 from the National Cancer Institute of the National Institutes of Health (NIH) to continue his groundbreaking research to develop new therapeutic agents for collagen-based diseases including multiple sclerosis, cancer and sepsis. [Florida Atlantic University] Press Release

Creative Medical Health, Inc. Files Patent on Stem Cell Therapy for Zika Virus Neurological Effects
Creative Medical Health, Inc. (CMH) announced filing of a patent covering the use of proprietary mesenchymal stem cell types in the treatment of neurological complications of Zika virus. The patent is a continuation of ongoing research at CMH that previously led to filing of intellectual property covering use of mesenchymal stem cells for multiple sclerosis. [Creative Medical Health, Inc. (Business Wire)] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Royan International Twin Congress: Reproductive Biomedicine & Stem Cell
August 31-September 2, 2016
Tehran, Iran

Visit our events page to see a complete list of events in the mesenchymal cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Research Positions – Stem/Progenitor Cells in Repair and Regeneration (University of Rochester Medical Center)

Research Technologist – Mesenchymal Stem Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Position – Craniofacial Molecular Biology (University of Southern California)

Engineering Project Lead (Cytonome)

Postdoctoral Training Fellow – Molecular and Stem Cell Biology (The Francis Crick Institute)

Postdoctoral Research Associate – Stem Cell Biology and Cell Differentiation (University of Illinois Chicago College of Medicine)

Postdoctoral Position – Epigenetic Regulation of Cell Fate, Cancer and Metabolism (University Medical Center Freiburg)

Postdoctoral Fellow – Mechanoregulation of Fibrosis and Vascular Injury (St. Michael’s Hospital)

Cell Culture Technician (California Institute of Technology)

Postdoctoral Positions – Tissue Repair/Inflammation (Institut Pasteur)

Independent Group Leaders – Regenerative Medicine (Center of Regenerative Medicine in Barcelona)

Tenure-Track Faculty Positions – Assistant/Associate/Full Professor (Nanyang Technological University)


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