Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

Mapping Cell-to-Tissue Graphs Across Human Placenta Histology Whole Slide Images Using Deep Learning With HAPPY

[Nature Communications] The authors developed the ‘Histology Analysis Pipeline.PY’ (HAPPY), a deep learning hierarchical method for quantifying the variability of cells and micro-anatomical tissue structures across placenta histology whole slide images.

Precision Delivery of Human Bone Marrow-Derived Mesenchymal Stem Cells into the Pancreas Via Intra-arterial Injection Prevents the Onset of Diabetes

[Stem Cells Translational Medicine] Using a mouse model, in which repetitive low doses of STZ induced a gentle, but progressive, hyperglycemia, investigators tested bone marrow-derived MSCs which were shown to be enriched with pro-angiogenic and immunomodulatory factors.

Assembled/Disassembled Modular Scaffolds for Multicellular Tissue Engineering

[Advanced Materials] Through assembling cell-laden modules, the macrophage-MSC, endothelial cell-MSC and chondrocyte-MSC co-culture models were successfully established.

Therapeutic and Immunomodulatory Potentials of Mesenchymal Stromal/Stem Cells and Immune Checkpoints Related Molecules

[Biomarker Research] Immune checkpoints and their ligands can be produced by MSCs and affect immune cell responses both through their secretion into the microenvironment or direct cell-to-cell interaction.

Interleukins and Interferons in Mesenchymal Stromal Stem Cell-Based Gene Therapy of Cancer

[Cytokine & Growth Factor Reviews] The authors provide a focused and detailed discussion on MSC-based gene therapy using interleukins and interferons, engineering techniques and insights on potential future advancements.

Charles River Announces Extension of Gene Therapy Manufacturing Alliance with NUS Yong Loo Lin School of Medicine

[Charles River Laboratories International, Inc. (Yahoo Finance)] Charles River Laboratories International, Inc. and National University of Singapore’s Yong Loo Lin School of Medicine announced a High Quality plasmid DNA development and manufacturing agreement.

Award of Up to $31 Million Supports Development of Osteoarthritis Treatment

[Washington University] With the goal of creating therapeutics that can help the body prevent or reverse the progression of osteoarthritis without surgical intervention, researchers at Washington University in St. Louis have received an award of up to $31 million from the Advanced Research Projects Agency for Health.

Optimizing the Delivery of mRNA to Mesenchymal Stem Cells for Tissue Engineering Applications

[Molecular Pharmaceutics] Researchers systematically screened a range of nonviral vectors to identify optimal transfection conditions for mRNA delivery to MSCs.

Platelet Concentrates Preconditioning of Mesenchymal Stem Cells and Combined Therapies: Integrating Regenerative Strategies for Enhanced Clinical Applications

[Cell Transplantation] Scientists review of the factors influencing the efficacy of MSCs transplantation and its association with platelet concentrates, investigating the impact of platelet concentrates’ composition, the age and health status of platelet donors, application methods, and environmental factors on the outcomes of relevant treatments.

Assessment of the Feasibility of Human Amniotic Membrane Stem Cell-Derived Cardiomyocytes In Vitro

[Heliyon] Scientists explored the feasibility of chemically inducing human amniotic membrane MSCs (hAMSCs) to differentiate into cardiomyocytes in vitro. Human amniotic membrane samples were obtained from routine cesarean sections at Far Eastern Memorial Hospital.

An Anti-Infection and Biodegradable TFRD-Loaded Porous Scaffold Promotes Bone Regeneration in Segmental Bone Defects -Experimental Studies

[International Journal of Surgery] Inspired by the local use of total flavonoids of Rhizoma Drynariae in the treatment of fracture, a novel 3D-printed HA/CMCS/PDA/TFRD scaffold with anti-infection, biodegradable and induced angiogenesis was designed, and to explore its preclinical value in segmental bone defect of tibia.

Mimicking Angiogenic Microenvironment of Alveolar Soft-Part Sarcoma in a Microfluidic Coculture Vasculature Chip

[Proceedings Of The National Academy Of Sciences Of The United States Of America] To mimic alveolar soft-part sarcoma angiogenic microenvironment, a microfluidic coculture vasculature chip has been developed as a 3D spheroid composed of mouse alveolar soft-part sarcoma, a layer of pericytes, and endothelial cells.

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.

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