Volume 2.34 | Aug 31

Mesenchymal Cell News 2.34, August 31, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


DLK-1 as a Marker to Distinguish Unrestricted Somatic Stem Cells and Mesenchymal Stromal Cells in Cord Blood 
Constitutive overexpression of delta-like 1/preadipocyte factor 1 (DLK-1/PREF1) in cord blood mesenchymal stromal cells resulted in a reduced adipogenic differentiation, whereas silencing of DLK-1 in unrestricted somatic stem cells resulted in adipogenic differentiation. [Stem Cells Dev]

Derive iPSCs feeder-free* with mTeSR®1
by STEMCELL Technologies
*Sun et al., PNAS, September 2009.
*Chan et al., Nature Biotechnology, October 2009.
STEMCELL Technologies Inc


Scientists Discover New Protein that Gets to the Roots of Obesity and Osteoporosis
Researchers describe a newly discovered protein, called “Sprouty,” responsible for regulating body fat and bone mass. [Press release from EurekAlert! discussing online prepublication in The FASEB Journal]

MesenCult®-XF Medium  
Obtain more MSCs in fewer passages with
MesenCult®-XF Medium

by STEMCELL Technologies

CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Sprouty1 is a Critical Regulatory Switch of Mesenchymal Stem Cell Lineage Allocation
Researchers tested whether Sprouty1 can modify the development of fat cells through its activity in regulating growth factors known to be important for adipogenesis. [FASEB J]

Receptor Activity Modifying Protein-3 Mediates the Protumorigenic Activity of Lysyl Oxidase-Like Protein-2
To understand the mechanisms involved, researchers examined the effect of lysyl oxidase-like protein-2 overexpression in MCF-7 cells on gene expression. [FASEB J]

siRNA Nanoparticle Functionalization of Nanostructured Scaffolds Enables Controlled Multilineage Differentiation of Stem Cells
Engineered morphogenesis necessitates spatially controlled development of multiple cell types within a scaffold implant. [Mol Ther]

Polysaccharide-Based Polyelectrolyte Multilayer Surface Coatings can Enhance Mesenchymal Stem Cell Response to Adsorbed Growth Factors
The goal of this work was to develop polysaccharide-based polyelectrolyte multilayers to bind and stabilize growth factors for delivery to mesenchymal stem cells. [Biomacromolecules]

Identification of a Common Gene Expression Signature Associated with Immature Clonal Mesenchymal Cell Populations Derived from Bone Marrow and Dental Tissues
In the present study researchers isolated and characterized clonal populations of mesenchymal stem/stromal cell-like populations derived from adult bone marrow, dental pulp, and periodontal ligament to identify potential biomarkers associated with long-lived multipotential stem cells. [Stem Cells Dev]

Shipping of Therapeutic Somatic Cell Products
This validation study provides a useful set of data for guiding shipments of therapeutic somatic cells in multi-institutional clinical trials. [Cytotherapy]

Prolonged Hypoxic Culture and Trypsinization Increase the Pro-Angiogenic Potential of Human Adipose Tissue-Derived Stem Cells
Researchers hypothesized that prolonged hypoxic (1% and 5% oxygen) culture and trypsinization would augment adipose tissue-derived stem cell (ASC) expression of anti-apoptotic and angiogenic cytokines and increase the angiogenic potential of ASC-conditioned media. [Cytotherapy]

Fibrin Glues in Combination with Mesenchymal Stem Cells to Develop a Tissue-Engineered Cartilage Substitute
Fresh fibrin and platelet-rich fibrin glues produced by the CryoSeal® FS System, in combination with human bone marrow-derived mesenchymal stem cells, were evaluated in this study. [Tissue Eng Part A]

Temporal Exposure to Chondrogenic Factors Modulates Human Mesenchymal Stem Cell Chondrogenesis in Hydrogels
Researchers investigated how cell density and temporal exposure to chondrogenic factors impacted chondrogenesis of human mesenchymal stem cells (hMSCs) encapsulated in poly(ethylene glycol) diacrylate hydrogels. [Tissue Eng Part A]

Adipose-Tissue-Derived and Wharton’s Jelly-Derived Mesenchymal Stromal Cells Suppress Lymphocyte Responses by Secreting Leukemia Inhibitory Factor
In this study, researchers investigated the capacity of mesenchymal stem cells derived from adipose tissue and Wharton’s jelly to modulate lymphocyte proliferation as well as their impact on regulatory T-cells. [Tissue Eng Part A]


Kythera and Bayer Dermatology Unit Intendis Enter Licensing and Development Agreement for Adipolytic Agent ATX-101
KYTHERA Biopharmaceuticals, Inc. and Intendis, Bayer HealthCare’s dermatology business, announced that they have entered into a licensing agreement granting Intendis rights to KYTHERA’s lead product candidate, ATX-101, outside of the US and Canada. [KYTHERA Biopharmaceuticals, Inc. Press Release]


NIH Director Collins Says Cell Ruling Won’t Halt Most Ongoing Grants
National Institutes of Health (NIH) Director Francis Collins said that the court injunction blocking federally funded research on human embryonic stem cells will not affect grant payments that have already gone out the door this year. [National Institutes of Health, United States]

NIH Director’s Response to Stem Cell Injunction [National Institutes of Health, United States]

Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-20861) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-21357) [National Institutes of Health, United States]

National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-21282) [National Institutes of Health, United States]

National Human Genome Research Institute; Notice of Closed Meeting (FR Doc. 2010-21317) [National Institutes of Health, United States]

National Human Genome Research Institute; Notice of Meetings (FR Doc. 2010-20858) [National Institutes of Health, United States]

National Center for Research Resources; Notice of Closed Meeting (FR Doc. 2010-21280) [National Institutes of Health, United States]

National Cancer Institute’s Best Practices for Biospecimen Resources (FR Doc. 2010-20872) [National Institutes of Health, United States]

Revolutionary Genome Sequencing Technologies — The $1000 Genome (SBIR [R43/R44]) (RFA-HG-10-014) [National Institutes of Health, United States]

Public Workshop on Medical Devices and Nanotechnology: Manufacturing, Characterization, and Biocompatibility Considerations [FR Doc. 2010-20837] [Food and Drug Administration, United States]

EVENTS (Listed by Date)

International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy

Hydra VI: The European Summer School on Stem Cells & Regenerative Medicine
September 11-17, 2010
Hydra, Greece

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States   

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

5th Annual Germany Society for Stem Cell Research
September 30-October 2, 2010
Lübeck, Germany

2010 World Stem Cell Summit
October 4-6, 2010
Detroit, United States

5th World Congress on Preventative and Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

17th Annual Meeting German Society for Gene Therapy (DG-GT e.V.)
October 6-9, 2010
Munich, Germany

bone-tec 2010 – International Bone-Tissue Engineering Congress
October 7-10, 2010
Hannover, Germany

The NYSCF Fifth Annual Translational Stem Cell Research Conference
October 12-13, 2010
New York, United States

International Federation of Adipose Therapeutics & Science (IFATS) 2010 Conference
October 22-24, 2010
Dallas, United States

2010 American Society for Matrix Biology (ASMB) Meeting
October 24-27, 2010
Charleston, United States

Stem Cell Society Singapore Symposium 2010
November 2-3, 2010

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Epithelial Plasticity and Epithelial to Mesenchymal Transition (A8)
January 21-26, 2011
Vancouver, Canada

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington DC, United States

Stem Cells in Development, Tissue Homeostasis and Disease
January 30-February 4, 2011
Santa Fe, United States

Stem Cells, Cancer and Metastasis (C4)
March 6-11, 2011
Keystone, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


Cell Therapy Technologist (Opexa Therapeutics)

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