Volume 2.38 | Sep 28

Mesenchymal Cell News 2.38, September 28, 2010.
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Biomimetic Hydrogels for Chondrogenic Differentiation of Human Mesenchymal Stem Cells to Neocartilage 
In this study, a collagen mimetic peptide was synthesized and chemically incorporated into a poly(ethylene glycol) (PEG) hydrogel through Michael addition chemistry. The PEG/collagen mimetic peptide hybrid hydrogel was used as a scaffold for encapsulation, proliferation and differentiation of human mesenchymal stem cells into neocartilage/chondrocytes. [Biomaterials]



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Researchers Engineer Adult Stem Cells That Do Not Age, Overcoming a Major Barrier to Progress in Regenerative Medicine
Biomedical researchers have engineered adult stem cells that scientists can grow continuously in culture, a discovery that could speed development of cost-effective treatments for diseases including heart disease, diabetes, immune disorders and neurodegenerative diseases. [University at Buffalo Press Release]

Controlling Bone Formation to Prevent Osteoporosis
In this study, the gene regulatory protein Maf was found to promote mesenchymal cell generation of osteoblasts and suppress their generation of fat cells. [Press release from EurekAlert! discussing online prepublication in the Journal of Clinical Investigation]


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Maf Promotes Osteoblast Differentiation in Mice by Mediating the Age-Related Switch in Mesenchymal Cell Differentiation
Here, researchers show an age-related decrease in the expression of Maf in mouse mesenchymal cells, which regulated mesenchymal cell bifurcation into osteoblasts and adipocytes by cooperating with the osteogenic transcription factor Runx2 and inhibiting the expression of the adipogenic transcription factor Pparg. [ J Clin Invest]

Methyl-H3K9-Binding Protein MPP8 Mediates E-Cadherin Gene Silencing and Promotes Tumour Cell Motility and Invasion
To further understand the function of H3K9 methylation, researchers have identified and characterized MPP8 as a methyl-H3K9-binding protein. [EMBO J]

The Effect of Incorporation of Exogenous Stromal Cell-Derived Factor-1 Alpha Within a Knitted Silk-Collagen Sponge Scaffold on Tendon Regeneration
This study developed a bioactive knitted silk-collagen sponge scaffold by incorporation of exogenous stromal cell-derived factor-1 alpha, to enable selective migration and homing of cells for in situ tendon regeneration. [Biomaterials]

Implantation of Cardiac Progenitor Cells Using Self-Assembling Peptide Improves Cardiac Function After Myocardial Infarction
Implantation of various types of cells into the heart has been reported to be effective for heart failure, however, it is unknown what kinds of cells are most suitable for myocardial repair. To examine which types of cells are most effective, researchers injected cells-PuramatrixTM (PM) complex into the border area and overlaid the cell-PM patch on the myocardial infarction area. [J Mol Cell Cardiol]

Selective Isolation and Differentiation of a Stromal Population of Human Embryonic Stem Cells with Osteogenic Potential
The derivation of osteogenic cells from human embryonic stem cells (hESC) has been hampered by the absence of easy and reproducible protocols. hESC grown in feeder-free conditions, often show a sub population of fibroblast-like, stromal cells growing between the colonies. Thus, researchers examined the possibility that these cells represent a population of stromal (mesenchymal) stem cells. [Bone]

Evaluation of Cross-Linked Chitosan Microparticles for Bone Regeneration
The objective of this preliminary study was to evaluate the application of chitosan-based microparticles in bone regeneration in vivo. [J Tissue Eng Regen Med]

Early Combined Treatment with Sildenafil and Adipose-Derived Mesenchymal Stem Cells Preserves Heart Function in Rat Dilated Cardiomyopathy
Researchers investigated whether early combined autologous adipose-derived mesenchymal stem cell and sildenafil therapy offer an additive benefit in preserving heart function in rat dilated cardiomyopathy. [J Transl Med]


Acquisition of U.S. Company Ratified by Mesoblast Shareholders
Shareholders of Australian regenerative medicine company, Mesoblast Limited, overwhelmingly approved the acquisition of its United States associate company, Angioblast Systems Inc. [Mesoblast Limited Press Release]

Patent is Filed on Shrink Nanotechnologies’ CellAlign Advanced Tissue Engineering Platform Technology
Shrink Nanotechnologies, Inc. announced that certain patent applications related to its advanced tissue engineering technology platform, CellAlign™, have been filed. [Shrink Nanotechnologies, Inc. Press Release]

University of South Florida Stem Cell Scientists Call for Research Ethics Consortium
Two University of South Florida stem cell researchers propose creating an independent national “Stem Cell Research Ethics Consortium” to provide better guidance on stem cell issues for regulatory agencies, law makers and policy makers. [University of South Florida Press Release]


NIH Releases Biennial Report of the Director
Dr. Francis S. Collins, M.D., Ph.D, director of the National Institutes of Health, announced the release of the Biennial Report of the Director, NIH, for fiscal years 2008 and 2009. The report provides an integrated portrait of NIH research activities, making it easy for Congress, advocates and patient groups and the general public to understand the many activities of the agency. [National Institutes of Health, United States]

The NCI Cancer Immunotherapy Trials Network (CITN) Seeks Member Clinical Sites (NOT-CA-10-034) [National Institutes of Health, United States]

Cancer Diagnostic and Therapeutic Agents Enabled by Nanotechnology (SBIR [U43/U44]) (PAR-10-286) [National Institutes of Health, United States]

Office of Biotechnology Activities, Office of Science Policy, Office of the Director; Notice of Meeting (FR Doc. 2010-23947) [National Institutes of Health, United States]

National Center for Research Resources; Notice of Closed Meeting (FR Doc. 2010-23852) [National Institutes of Health, United States]

Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-23847) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-23849) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-23860) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-23952) [National Institutes of Health, United States]

National Cancer Institute; Notice of Meeting (FR Doc. 2010-23543) [National Institutes of Health, United States]

National Cancer Institute; Notice of Closed Meetings (FR Doc. 2010-23545) [National Institutes of Health, United States]

EVENTS (Listed by Date)

NEW  5th Annual Meeting of the German Society for Stem Cell Research
September 30-October 2, 2010
Lübeck, Germany

NEW Stem Cells and Regeneration – NIH Sponsored Advanced Training Courses
October 3-9, 2010
Woods Hole, United States

NEW 4th International Conference on Biofabrication
October 4-6, 2010
Philadelphia, United States

2010 World Stem Cell Summit
October 4-6, 2010
Detroit, United States

5th World Congress on Preventive & Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

17th Annual Meeting German Society for Gene Therapy (DG-GT e.V.)
October 6-9, 2010
Munich, Germany

bone-tec 2010 – International Bone-Tissue-Engineering Congress
October 7-10, 2010
Hannover, Germany

Functional Stem Cell and Regeneration
October 9-10, 2010
Kansas City, United States

New York Stem Cell Foundation 5th Annual Translational Stem Cell Research Conference
October 12-13, 2010
New York City, United States

4th International Symposium Stem Cells, Development and Regulation
October 12-14, 2010
Amsterdam, Netherlands

NEW The American Society for Bone and Mineral Research (ASBMR) 2010 Annual Meeting
October 15-19, 2010
Toronto, Canada

NEW Stem Cells and Regenerative Medicine – New Solutions to Old Problems
October 18-20, 2010
San Antonio, United States

International Federation of Adipose Therapeutics & Science (IFATS) 2010 Conference
October 22-24, 2010
Dallas, United States

American Society for Matrix Biology (ASMB) 2010 Biennial Meeting
October 24-27, 2010
Charleston, United States

NEW World Stem Cells & Regenerative Medicine Congress Asia 2010
October 26-28, 2010
Seoul, Korea

FDA Public Workshop on Cell and Gene Therapy Clinical Trials in Pediatric Populations
November 2, 2010
North Bethesda, United States

Stem Cell Society Singapore Symposium 2010: Translating Science to Therapy
November 2-3, 2010

NEW  6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom

NEW  9th Annual American Association for Cancer Research (AACR) International Conference: Frontiers in Cancer Prevention Research
November 7-10, 2010
Philadelphia, United States

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms
November 15-18, 2010
Nara, Japan

NEW  22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics
November 16-19, 2010
Berlin, Germany

NEW Translational Excellence in Regenerative Medicine (TeRM) – Biophysical Stimuli and Mass Transport for Tissue Development
November 18-19, 2010
Lattrop, The Netherlands

Stem Cell Network’s 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Alberta

NEW First Berlin-Brandenburg School for Regenerative Therapies (BSRT) PhD Symposium
December 1-3, 2010
Berlin, Germany

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society – North America (TERMIS-NA) 2010 Annual Conference
December 5-8, 2010
Orlando, United States

NEW The American Society for Cell Biology 50th Annual Meeting
December 11-15, 2010
Philadelphia, United States

Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

NEW Select Biosciences 5th Annual Stem Cells World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, DC, United States

Keystone Symposia: Stem Cells in Development, Tissue Homeostasis and Disease
January 30-February 4, 2011
Santa Fe, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

Stem Cells, Cancer and Metastasis (C4)
March 6-11, 2011
Dillon, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Europe 2010 Annual Conference
June 7-10, 2011
Granada, Spain

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

NEW Tissue Engineering & Regenerative Medicine International Society (TERMIS) 2011 Asia Pacific Meeting (TERMIS AP 2011)
August 3-5, 2011

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


Cell Therapy Technologist (Opexa Therapeutics)

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