Volume 2.40 | Oct 12

Mesenchymal Cell News 2.40, October 12, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Mesenchymal Stromal Cells Expressing ErbB-2/Neu Elicit Protective Anti-Breast Tumor Immunity In Vivo , Which Is Paradoxically Suppressed by IFN-Gamma and Tumor Necrosis Factor-Alpha Priming 
Researchers tested here whether immunization with mesenchymal stromal cells could break immune tolerance towards the ErbB-2/HER-2/neu tumor antigen and the effects of priming with IFN-gamma and tumor necrosis factor-alpha on this process. [Cancer Res]

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SPECIAL FEATURE

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SCIENCE NEWS

Stem Cell Transplant May Help MS, ALS Patients
Patients with multiple sclerosis (MS) or amyotrophic lateral sclerosis (ALS) who received mesenchymal stromal cell transplantation in a recent Phase I/II trial experienced stabilization and, in some cases, improvement. [Press release from The Cleveland Clinic discussing online prepublication in the Archives of Neurology]

mTeSR  
Derive iPSCs feeder-free* with mTeSR®1
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*Sun et al., PNAS, September 2009.
*Chan et al., Nature Biotechnology, October 2009.
STEMCELL Technologies Inc
 


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Epithelial-to-Mesenchymal Transition Promotes Tubulin Detyrosination and Microtentacles that Enhance Endothelial Engagement
Researchers report here that epithelial-to-mesenchymal transition induced through ectopic expression of Twist or Snail promotes alpha-tubulin detyrosination and the formation of tubulin-based microtentacles in detached HMLEs. [Cancer Res]

The Osteogenic Differentiation of Human Osteoprogenitor Cells on Anodic-Plasma-Chemical Treated Ti6Al7Nb
In the present study, researchers compared the potential of anodic plasma-chemical surface treatment of high-strength titanium alloys with vacuum plasma spray treatment and yellow gold anodization in supporting osteogenic differentiation of two different osteoprogenitor cell types. [Biomaterials]

The Spreading, Migration and Proliferation of Mouse Mesenchymal Stem Cells Cultured Inside Hyaluronic Acid Hydrogels
In this study, researchers synthesized hyaluronic acid hydrogels that could be degraded through a combination of cell-released enzymes and used them to culture mouse mesenchymal stem cells. [Biomaterials]

Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis
The objective of this study was to evaluate the feasibility, safety, and immunological effects of intrathecal and intravenous administration of autologous mesenchymal stem cells in patients with multiple sclerosis and amyotrophic lateral sclerosis. [Arch Neurol]

Relevance of the Mevalonate Biosynthetic Pathway in the Regulation of Bone Marrow Mesenchymal Stromal Cell-Mediated Effects on T Cell Proliferation and B Cell Survival
Bone marrow mesenchymal stromal cells can suppress T lymphocyte proliferation, but promote survival of normal and malignant B cells, thus representing a possible target for new therapeutic schemes. Herein, researchers defined the effects of cholesterol synthesis inhibitors on the interaction between these mesenchymal stromal cells and T or B lymphocytes. [Haematologica]

Human Cardiac and Bone Marrow Stromal Cells Exhibit Distinctive Properties Related to Their Origin
The objective of the present work was the comparison of in vitro and in vivo properties of adult human cardiac stromal cells to those of syngeneic bone marrow mesenchymal stromal cells. [Cardiovasc Res]

Human Umbilical Cord Blood Derived Mesenchymal Stem Cells Upregulate Myelin Basic Protein in Shiverer Mice
In the present study, researchers aimed to investigate the potential of human umbilical cord blood-derived pluripotent mesenchymal stem cells to myelinate the axons of shiverer mice brains. [Stem Cells Dev]

Effect of the Modulation of Leucine Zipper Tumor Suppressor 2 Expression on Proliferation of Various Cancer Cells Functions as a Tumor Suppressor
Researchers showed that NF-kappaB-induced modulation of beta-catenin/Tcf pathway is regulated by leucine zipper tumor suppressor 2 (lzts2) expression in mesenchymal stem cells and several cancer cells, and that NF-kappaB-induced lzts2 expression is differentially regulated among cancer cell types. [Mol Cell Biochem]


INDUSTRY NEWS

BrainStorm Receives Approval to Begin Clinical Trial of Adult Stem Cell Therapy in Patients with ALS
BrainStorm Cell Therapeutics Inc. announced that the Israeli Ministry of Health has granted clearance for a Phase I/II clinical trial using the company’s autologous NurOwn™ stem cell therapy in patients with amyotrophic lateral sclerosis (ALS). [BrainStorm Cell Therapeutics Inc. Press Release]

Medistem Signs Commercialization Agreement for Endometrial Regenerative Cells With General Biotechnology LLC
Medistem Inc. announced it has entered into a commercialization agreement with the Indianapolis-based company, General Biotechnology LLC, for sale of its universal donor Endometrial Regenerative Cells (ERC) as a research reagent to qualified academic and corporate institutions. [The Wall Street Journal]

STEMSOFT Connect – A Simplified Solution to a Complex Problem
STEMSOFT Software Inc. is pleased to announce the release of their new standard interfaces, STEMSOFT Connect(TM). [STEMSOFT Software Inc. Press Release]


POLICY NEWS

NIH Announces New Program to Accelerate Research Independence
The National Institutes of Health intends to invest approximately $60 million over the next five years in the NIH Director’s Early Independence Award program to help junior investigators leapfrog over traditional post-doctoral training and move into independent academic positions at U.S. institutions, directly upon completion of their graduate research degrees. [National Institutes of Health, United States]

NIH Launches Genotype-Tissue Expression Project
The National Institutes of Health (NIH) announced awards to support an initiative to understand how genetic variation may control gene activity and its relationship to disease. Launched as a pilot phase, the Genotype-Tissue Expression (GTEx) project will create a resource researchers can use to study inherited susceptibility to illness and will establish a tissue bank for future biological studies. [National Institutes of Health, United States]

FDA’s $25 Million Pitch for Improving Drug Regulation
The U.S. Food and Drug Administration (FDA) is pressing for a big funding boost for “regulatory science”- research that can help it evaluate new treatments better and faster. [Food and Drug Administration, United States]

FDA to Push for More Investment in Science
Health regulators plan to spend millions of dollars to step up their scientific prowess in a move that officials say will help quickly get new treatments to patients and protect the public against possible health threats. [Food and Drug Administration, United States]

FDA Issues Regulatory Science Report
The U.S. Food and Drug Administration unveiled a report outlining the agency’s plans to advance regulatory science through its Regulatory Science Initiative. [Food and Drug Administration, United States]

Plan to Develop a Genetic Testing Registry at the National Institutes of Health; Public Meeting; Request for Comments (FR Doc. 2010-25411) [National Institutes of Health, United States]

Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-25171)  [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25180)  [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25185)  [National Institutes of Health, United States]

National Center for Research Resources; Notice of Closed Meeting (FR Doc. 2010-25176)  [National Institutes of Health, United States]

National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting (FR Doc. 2010-25172) [National Institutes of Health, United States]


EVENTS (Listed by Date)

The American Society for Bone and Mineral Research (ASBMR) 2010 Annual Meeting
October 15-19, 2010
Toronto, Canada

Stem Cells and Regenerative Medicine – New Solutions to Old Problems
October 18-20, 2010
San Antonio, United States

International Federation of Adipose Therapeutics & Science (IFATS) 2010 Conference
October 22-24, 2010
Dallas, United States

American Society for Matrix Biology (ASMB) 2010 Biennial Meeting
October 24-27, 2010
Charleston, United States

2nd Annual Stem Cells Asia and Regenerative Medicine Congress
October 26-28, 2010
Seoul, Korea

FDA Public Workshop on Cell and Gene Therapy Clinical Trials in Pediatric Populations
November 2, 2010
North Bethesda, United States

Stem Cell Society Singapore Symposium 2010: Translating Science to Therapy
November 2-3, 2010
Singapore

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom

9th Annual American Association for Cancer Research (AACR) International Conference: Frontiers in Cancer Prevention Research
November 7-10, 2010
Philadelphia, United States

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms
November 15-18, 2010
Nara, Japan

22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics
November 16-19, 2010
Berlin, Germany

Translational Excellence in Regenerative Medicine (TeRM) – Biophysical Stimuli and Mass Transport for Tissue Development
November 18-19, 2010
Lattrop, The Netherlands

Stem Cell Network’s 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Alberta

First Berlin-Brandenburg School for Regenerative Therapies (BSRT) PhD Symposium
December 1-3, 2010
Berlin, Germany

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society – North America (TERMIS-NA) 2010 Annual Conference
December 5-8, 2010
Orlando, United States

The American Society for Cell Biology 50th Annual Meeting
December 11-15, 2010
Philadelphia, United States

Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

Select Biosciences 5th Annual Stem Cells World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, DC, United States

Keystone Symposia: Stem Cells in Development, Tissue Homeostasis and Disease
January 30-February 4, 2011
Santa Fe, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

Stem Cells, Cancer and Metastasis (C4)
March 6-11, 2011
Dillon, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Europe 2010 Annual Conference
June 7-10, 2011
Granada, Spain

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

Tissue Engineering & Regenerative Medicine International Society (TERMIS) 2011 Asia Pacific Meeting (TERMIS AP 2011)
August 3-5, 2011
Singapore

Visit our events page  to stay up to date with the latest events in the cell, gene and immunotherapy community.

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