Volume 2.41 | Oct 19

Mesenchymal Cell News 2.41, October 19, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Hypoxia Inhibits Senescence and Maintains Mesenchymal Stem Cell Properties Through Downregulation of E2A-p21 by HIF-TWIST 
Results support the method of low-density hypoxic culture for efficiently expanding mesenchymal stem cells without losing stem cell properties and increasing tumorigenecity. [Blood]

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SCIENCE NEWS

Scientists Turn Stem Cells into Cells for Cartilage Repair
Researchers took human embryonic stem cells and developed a culture procedure involving a precise sequential program of conditions to specifically produce chondrocytes. [Press release from The University of Manchester discussing online prepublication in Nature Biotechnology]
 
Cell-Signaling Link Between Muscle Inflammation and Regeneration Identified
An international team of scientists has identified and described, for the first time, a cell-signaling pathway in mice that directs adult muscle stem cells to repair damaged muscle tissue. [Press release from the National Institute of Arthritis and Musculoskeletal and Skin Diseases discussing online prepublication in Cell Stem Cell]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

TNF/p38Alpha/Polycomb Signaling to Pax7 Locus in Satellite Cells Links Inflammation to the Epigenetic Control of Muscle Regeneration
How regeneration cues are converted into the epigenetic information that controls gene expression in adult stem cells is currently unknown. Researchers identified an inflammation-activated signaling in muscle stem (satellite) cells, by which the polycomb repressive complex 2 represses Pax7 expression during muscle regeneration. [Cell Stem Cell]
 
Antibacterial Effect of Human Mesenchymal Stem Cells is Mediated in Part from Secretion of the Antimicrobial Peptide LL-37
Mesenchymal stem cells as well as their conditioned medium demonstrated marked inhibition of bacterial growth in comparison to control medium or normal human lung fibroblasts. [Stem Cells]
 
Irradiation Enhances the Tumor Tropism and Therapeutic Potential of TRAIL-Secreting Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Glioma Therapy
Researchers show that tumor irradiation enhances the tumor tropism of human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) and the therapeutic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) delivered by UCB-MSCs. [ Stem Cells]

Osteoarthritic Chondrocyte-Secreted Morphogens Induce Chondrogenic Differentiation of Human Mesenchymal Stem Cells
The study determined the effect of morphogenetic signals from osteoarthritis chondrocytes on chondrogenic differentiation of human mesenchymal stem cells. [Arthritis Rheum]
 
Substance P Stimulates the Recovery of Bone Marrow After Irradiation
Results suggest that substance P alleviates gamma-radiation-induced damage to mouse bone marrow stem cells and human mesenchymal stem cells via regulation of the apoptotic pathway. [J Cell Physiol]
 
VEGF-Modified Human Embryonic Mesenchymal Stem Cell Implantation Enhances Protection Against Cisplatin-Induced Acute Kidney Injury
Data suggest that vascular endothelial growth factor (VEGF)-modified human mesenchymal stem cell implantation could provide advanced benefits in the protection against acute kidney injury by increasing anti-apoptosis effects and improving microcirculation and cell proliferation. [Am J Physiol Renal Physiol]
 
Cell-Mediated Transgenesis in Rabbits: Chimeric and Nuclear Transfer Animals
Rabbit mesenchymal stem cells were markedly more successful than embryonic stem cells as nuclear donors. [Biol Reprod]
 
Vibrational Spectroscopy Differentiates Between Multipotent and Pluripotent Stem Cells
Researchers show that infrared spectroscopy of embryonic and adult mesenchymal stem cells have different spectral signatures based on the amount of lipids in their cytoplasm (confirmed with cytological staining). [Analyst]
 
Neural Marker Expression in Rat Bone Marrow Mesenchymal Stem Cell Cultures Treated with Neurosteroids
Findings highlight a significant up and down modulation of nestin, neurofilament, beta-tubulin and MAP-kinase expression in neurosteroid-treated bone marrow mesenchymal stem cells. [Neurochem Res]

INDUSTRY NEWS

Sanofi-aventis Establishes Research Collaboration with Harvard University
Sanofi-aventis announced a research collaboration with Harvard University. The goal of the collaboration is to advance knowledge in the area of human health through basic and applied research and to promote scientific exchange between Harvard University and Sanofi-aventis. [Sanofi-aventis Press Release]

American Cancer Society Awards New Research and Training Grants
The American Cancer Society has awarded 94 national research and training grants totaling $46,633,000 to 70 institutions nationwide in the first of two grants cycles for 2011. [American Cancer Society Press Release]
 
Cytomedix Secures $13 Million in Committed Funding
Cytomedix, Inc., a leading developer of biologically active regenerative therapies for wound care, inflammation and angiogenesis, announced that the Company has secured approximately $13 million in current and future funding via a registered direct offering and commitments under two separate equity purchase agreements. [Cytomedix, Inc. Press Release]
 
The New York Stem Cell Foundation Announces 2010 NYSCF-Investigators in Conjunction with Fifth Annual Translational Stem Cell Conference
In an expansion of its ongoing effort to promote the next generation of stem cell scientists, The New York Stem Cell Foundation (NYSCF) named the first six NYSCF Investigators. Each of the NYSCF-Robertson and NYSCF-Helmsley Investigators will receive up to $1.5 million over the next five years to expand their own laboratories, train other scientists and foster innovative high-risk/high reward research to explore the therapeutic potential of stem cells derived from humans and model organisms. [The New York Stem Cell Foundation Press Release]

POLICY NEWS

IQWiG: Law Must Prescribe Obligation to Publish All Clinical Trials
If the currently discussed draft on the “Law on the Reorganization of the Pharmaceutical Market” (AMNOG) is implemented, drug manufacturers will in future have to register their clinical trials at inception and publish results after completion. [Institute for Quality and Efficiency in Health Care (IQWiG), Germany]

European Medicines Agency Strengthens Rules on Conflicts of Interests of Its Scientific Experts
The European Medicines Agency has published new rules on how the Agency will be handling potential conflicts of interests of its scientific experts, following endorsement by its Management Board. [European Medicines Agency, European Union]

FDA Writes Prescription for IT Innovation
The Food and Drug Administration is prioritizing IT as part of its five-year strategic plan, including accelerating a program to build innovative devices to improve field and laboratory analysis. [Food and Drug Administration, United States]
 
Proposed Collection; Comment Request; National Evaluation of the Clinical and Translational Science Awards (CTSA) Initiative (FR Doc. 2010-25589) [Department of Health and Human Services, United States]

Agency Information Collection Request. 30-Day Public Comment Request (FR Doc. 2010-25587) [Department of Health and Human Services, United States]
 
Partnerships to Advance the National Occupational Research Agenda (NORA) (FR Doc. 2010-25973) [Centers for Disease Control and Prevention, United States]
 
Draft Guidance for Industry: Early Clinical Trials With Live Biotherapeutic Products: Chemistry, Manufacturing, and Control Information; Availability (FR Doc. 2010-25850) [Food and Drug Administration, United States]
 
Draft Guidance for Industry on Investigational New Drug Applications–Determining Whether Human Research Studies Can Be Conducted Without an Investigational New Drug Application; Availability (FR Doc. 2010-25851) [Food and Drug Administration, United States]
 
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26028) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26033) [National Institutes of Health, United States]
 
National Institute of General Medical Sciences; Notice of Closed Meeting (FR Doc. 2010-26037) [National Institutes of Health, United States]
 
National Institute of General Medical Sciences; Notice of Closed Meeting (FR Doc. 2010-26075) [National Institutes of Health, United States]
 
Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-26036) [National Institutes of Health, United States]

EVENTS (Listed by Date)

International Federation of Adipose Therapeutics & Science (IFATS) 2010 Conference
October 22-24, 2010
Dallas, United States

American Society for Matrix Biology (ASMB) 2010 Biennial Meeting
October 24-27, 2010
Charleston, United States

2nd Annual Stem Cells Asia and Regenerative Medicine Congress
October 26-28, 2010
Seoul, Korea

FDA Public Workshop on Cell and Gene Therapy Clinical Trials in Pediatric Populations
November 2, 2010
North Bethesda, United States

NEW  5th UK Cancer Stem Cell Symposium
November 2, 2010
London, United Kingdom

Stem Cell Society Singapore Symposium 2010: Translating Science to Therapy
November 2-3, 2010
Singapore

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom

9th Annual American Association for Cancer Research (AACR) International Conference: Frontiers in Cancer Prevention Research
November 7-10, 2010
Philadelphia, United States

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms
November 15-18, 2010
Nara, Japan

22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics
November 16-19, 2010
Berlin, Germany

Translational Excellence in Regenerative Medicine (TeRM) – Biophysical Stimuli and Mass Transport for Tissue Development
November 18-19, 2010
Lattrop, The Netherlands

Stem Cell Network’s 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Alberta

First Berlin-Brandenburg School for Regenerative Therapies (BSRT) PhD Symposium
December 1-3, 2010
Berlin, Germany

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Tissue Engineering & Regenerative Medicine International Society – North America (TERMIS-NA) 2010 Annual Conference
December 5-8, 2010
Orlando, United States

NEW 5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

The American Society for Cell Biology 50th Annual Meeting
December 11-15, 2010
Philadelphia, United States

Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, DC, United States

Keystone Symposia: Stem Cells in Development, Tissue Homeostasis and Disease
January 30-February 4, 2011
Santa Fe, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

Stem Cells, Cancer and Metastasis (C4)
March 6-11, 2011
Dillon, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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