Volume 3.18 | May 10

Mesenchymal Cell News 3.18, May 10, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
TOP STORY

Anti-Inflammatory Protein TSG-6 Secreted by Activated MSCs Attenuates Zymosan-Induced Mouse Peritonitis by Decreasing TLR2/NF-κB Signaling in Resident Macrophages
Here researchers demonstrated that human mesenchymal stem/progenitor cells (hMSCs) are activated by inflammatory signals to secrete the anti-inflammatory protein, TSG-6 and thereby create a negative feedback loop that reduces inflammation in zymosan-induced peritonitis. [Blood]

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SCIENCE NEWS

Columbia Engineers Patch A Heart
Researchers have established a new method to patch a damaged heart using a tissue-engineering platform that enables heart tissue to repair itself. [Press release from Columbia University School of Engineering discussing online prepublication in the Proceedings of the National Academy of Sciences USA]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Composite Scaffold Provides a Cell Delivery Platform for Cardiovascular Repair
Researchers have established a tissue engineering platform for the delivery of human mesenchymal progenitor cells by a fully biological composite scaffold. [Proc Natl Acad Sci U S A]

Bone Marrow Derived Mesenchymal Stromal Cells Inhibit Th2-Mediated Allergic Airways Inflammation in Mice
To ascertain the effects of systemic administration of bone marrow-derived mesenchymal stromal cells in a mouse model of Th2-mediated allergic airways inflammation, ovalbumin-induced allergic airways inflammation was induced in wild type C57BL/6 and BALB/c mice as well as in IFN(gamma) receptor null mice. [Stem Cells]

ZNF145 Improves Differentiation Potential of Human MSCs for Cartilage Regeneration and Repair as an Upstream Factor of Sox9
Researchers have found that ZNF145, a transcriptional factor, was upregulated during three lineage differentiation of human mesenchymal stem cells (hMSCs). The present study was undertaken to validate whether this novel transcription factor ZNF145 is useful for the repair and regeneration of cartilage. [Arthritis Rheum]

Functional Mesenchymal Stem Cell Niches in Adult Mouse Knee Joint Synovium In Vivo
Researchers previously reported that human synovium contains cells that, after culture expansion, display properties of mesenchymal stem cells (MSCs). The objective of this study was to identify MSCs in native synovium in vivo. [Arthritis Rheum]

Proliferation and Differentiation Potential of Human Adipose-Derived Mesenchymal Stem Cells Isolated from Elderly Patients with Osteoporotic Fractures
It is concluded that the proliferation and osteogenic differentiation of adipose-derived mesenchymal stem cells (ADSCs) were less affected by age and multiple passage than bone marrow-derived mesenchymal stem cells, suggesting that ADSCs may become a potentially effective therapeutic option for cell-based therapy, especially in elderly patients with osteoporosis. [J Cell Mol Med]

Repair of Rat Sciatic Nerve Gap by a Silk Fibroin-Based Scaffold Added with Bone Marrow Mesenchymal Stem Cells
Here researchers developed a new design of tissue-engineered nerve grafts by introducing bone marrow mesenchymal stem cells of rats, as support cells, into a silk fibroin (SF)-based scaffold, which was composed of a SF nerve guidance conduit and oriented SF filaments as the conduit lumen filler. [Tissue Eng Part A]

Purification and Long-Term Expansion of Multipotent Endothelial-Like Cells with Potential Cardiovascular Regeneration
Here, researchers propose the isolation and characterization of multipotent endothelial-like cells with the capacity to maintain their vascular progenitor properties for long periods of time. [Stem Cells Dev]

Bone Morphogenetic Protein-2 in Biodegradable Gelatin and ß-Tricalcium Phosphate Sponges Enhances the In Vivo Bone-Forming Capability of Bone Marrow Mesenchymal Stem Cells
The results indicate that the combination of mesenchymal stem cells, GT and bone morphogenetic protein synergistically enhances osteogenic capability and provides a rational basis for their clinical application in bone reconstruction. [J Tissue Eng Regen Med]

Adipose-Derived Mesenchymal Stem Cell Protects Kidneys against Ischemia-Reperfusion Injury through Suppressing Oxidative Stress and Inflammatory Reaction
Researchers hypothesized that adipose-derived mesenchymal stem cells protect the kidney against oxidative stress and inflammatory stimuli in rat during renal IR injury. [J Transl Med]

INDUSTRY NEWS

Nearly 30 Percent of New CIRM Awards Go to UC San Diego Stem Cell Researchers
University of California (UC), San Diego scientist garnered 8 of the total 27 of Basic Biology III awards announced by the Independent Citizens’ Oversight Committee of the California Institute for Regenerative Medicine (CIRM). [University of California, San Diego Press Release]

Six UCLA Stem Cell Scientists Awarded More than $8 Million in State Grants
Six scientists with the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at the University of California, Los Angeles (UCLA) were awarded more than $8 million in grants from California’s state stem cell agency on May 3 to investigate basic mechanisms underlying stem cell biology and differentiation. [University of California, Los Angeles Press Release]

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Screening Stem Cells 2011: From Reprogramming to Regenerative Medicine
September 26-27, 2011
Boston, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.
JOB OPPORTUNITIES

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Implementation Coordinator – Maternity Leave Contract (STEMSOFT Software Inc.)

Assistant Professor/Tissue Engineer (The University of Texas Medical School at Houston)

Experienced Researcher Marie Curie Fellowship in Cancer Stem Cell Research (University Paris Diderot)


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