Volume 3.36 | Sep 13

Mesenchymal Cell News 3.36, September 13, 2011
     In this issue: Publications | Science News | Industry News | Policy News | Events | Jobs 
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TOP STORY
Mesenchymal Stem Cells Induce Resistance to Chemotherapy through the Release of Platinum-Induced Fatty Acids
Here, researchers demonstrate that endogenous mesenchymal stem cells become activated during treatment with platinum analogs and secrete factors that protect tumor cells against a range of chemotherapeutics. [Cancer Cell] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Reversal of Serological, Immunological and Histological Dysfunction in Systemic Lupus Erythematosus Mice by Long-Term Serial Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation
In this study, the efficacy of human adipose tissue-derived mesenchymal stem cell transplantation in systemic lupus erythematosus was investigated and the optimal transplantation window of stem cells was determined either before or after disease onset. [Arthritis Rheum] Abstract

MicroRNAs in the Regulation of Interfacial Behaviors of MSCs Cultured on Microgrooved Surface Pattern
This study elucidated the important roles of miRNAs in the regulation processes of the microenvironment triggered cell behaviors, and provided clues for the PHA biomedical materials development. [Biomaterials] Abstract

TGFß1 Contributes to Cardiomyogenic-Like Differentiation of Human Bone Marrow Mesenchymal Stem Cells
The majority of the protocols for cardiomyocyte differentiation of mesenchymal stem cells use 5-azacytidine as an inducer. As transforming growth factor ß1 and 5-azacytidine share similar target signaling pathways, researchers examined whether transforming growth factor ß1 can play a role in cardiac differentiation process in human mesenchymal stem cell of bone marrow origin. [Int J Cardiol] Abstract

Mesenchymal Stem Cell-Secreted Soluble Signaling Molecules Potentiate Tumor Growth
In the present study, researchers investigate whether the physical presence or the continuous presence of mesenchymal stem cells is required for enhanced tumor growth. [Cell Cycle] Abstract

Tumor-Conditioned Mesenchymal Stem Cells Display Hematopoietic Differentiation and Diminished Influx of Ca2+
In this study, researchers analyzed the interaction of bone marrow derived mesenchymal stem cells and cancer cells by cell-cell contact and transwell culture system. [Stem Cells Dev] Abstract

Improved Mesenchymal Stem Cells Attachment and In Vitro Cartilage Tissue Formation on Chitosan-Modified Poly(L-lactide-co-epsilon-caprolactone) Scaffold
A porous elastomeric poly L-lactide-co-e-caprolactone (PLCL) was generated and cross-linked at the surface to chitosan to improve its wettability. Human bone marrow derived mesenchymal stem cells attachment, morphological change, proliferation and in vitro cartilage tissue formation on the chitosan-modified PLCL scaffold was compared to the unmodified PLCL scaffold. [Tissue Eng Part A] Abstract

Mesenchymal Stem Cells Attenuate Angiotensin II-Induced Aortic Aneurysm Growth in Apolipoprotein E-Deficient Mice
To clarify whether mesenchymal stem cells (MSCs) might be useful for aortic aneurysm cell therapy, researchers examined the effect of MSCs on vascular smooth muscle cells and macrophages in vitro, on aortic tissue ex vivo, and on aorta in vivo. [J Vasc Surg] Abstract

Exosomes from Ovarian Cancer Cells Induce Adipose Tissue-Derived Mesenchymal Stem Cells to Acquire the Physical and Functional Characteristics of Tumor-Supporting Myofibroblasts
In the current study, researchers determined the biological effect of exosomes from two ovarian cancer cell lines (SK-OV-3 and OVCAR-3) on adipose tissue-derived mesenchymal stem cells. [Gynecol Oncol] Abstract

Phenotypic Correction of Hemophilia A in Sheep by Postnatal Intraperitoneal Transplantation of FVIII-Expressing MSC
This novel, non-ablative mesenchymal stem cell (MSC) transplantation was straightforward, safe, and converted life-threatening, debilitating hemophilia A to a moderate phenotype in a large animal model. [Exp Hematol] Abstract

Exosomes from Breast Cancer Cells Can Convert Adipose Tissue-Derived Mesenchymal Stem Cells Into Myofibroblast-Like Cells
In this study, researchers investigated the influence of tumor cell-derived exosomes on mesenchymal stem cells (MSCs) by treating adipose tissue-derived MSCs with breast cancer-derived exosomes. [Int J Oncol] Abstract

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SCIENCE NEWS

UC Davis Neurosurgeons Use Adult Stem Cells to Grow Neck Vertebrae
Neurosurgery researchers have used a new, leading-edge stem cell therapy to promote the growth of bone tissue following the removal of cervical discs to relieve chronic, debilitating pain. [University of California Davis] Press Release

INDUSTRY NEWS

Bolli Receives $12.8 Million NIH Grant Renewal for Adult Stem Cell Project
University of Louisville cardiologist and researcher Roberto Bolli has received a $12.8 million renewal grant from the National Institutes of Health for continued research with adult stem cells. [University of Louisville] Press Release

Stem Cell Efforts to Treat Neurological Disease Bolstered with $4.5 Million
The laboratory headed by Steven Goldman, M.D., Ph.D. has received $4.5 million in new funding to further its efforts to use stem cells and related molecules to treat several feared disorders for which there are currently no cures. [University of Rochester Medical Center] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW 1st Annual Congress on Stem Cell Research
September 28-October 2, 2011
Sapanca, Turkey


Visit
our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Research and Development Technologist (STEMCELL Technologies)

Mesenchymal Stem Cell Fellowship (Universita’ Di Bologna)

Postdoctoral Positions in Stem Cells and Immunology (University of Connecticut)

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