Volume 3.42 | Oct 25

Mesenchymal Cell News 3.42, October 25, 2011
     In this issue: PublicationsIndustry News | Policy News | Events | Jobs 
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TOP STORY
SOX2 Has a Crucial Role in the Lineage Determination and Proliferation of Mesenchymal Stem Cells through Dickkopf-1 and c-MYC
Researchers show that SOX2 directly regulates DKK1 expression and, as a consequence, determines the differentiation lineage of human mesenchymal stem cells. [Cell Death Differ] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Soluble Intracellular Adhesion Molecule-1 Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cell Reduces Amyloid-β Plaques
Researchers suggest that human umbilical cord blood mesenchymal stem cell-derived soluble intracellular adhesion molecule-1 (sICAM-1) decreases amyloid-β plaques by inducing neprilysin expression in microglia through the sICAM-1/lymphocyte function-associated antigen-1 signaling pathway. [Cell Death Differ] Abstract

Effects of Endothelial Cells on Human Mesenchymal Stem Cell Activity in a Three-Dimensional In Vitro Model
Researchers underline the importance of three-dimensional (3D) heterotypic cell-cell interactions in the regulation of mesenchymal stem cell behaviour, suggesting that multicellular cocktails and/or 3D-based delivery strategies may be beneficial for bone repair. [Eur Cell Mater] Abstract

Proteome Analysis During Chondrocyte Differentiation in a New Chondrogenesis Model Using Human Umbilical Cord Stroma Mesenchymal Stem Cells
The purpose of this study was to determine which proteins were differentially expressed during chondrogenesis. [Mol Cell Proteomics] Abstract

Non-Integrating Knockdown and Customized Scaffold Design Enhances Human Adipose Derived Stem Cells in Skeletal Repair
Researchers suggest that genetic targeting of human adipose-derived stem cells (hASCs) combined with custom scaffold design can optimize hASCs for skeletal regenerative medicine. [Stem Cells] Abstract

Human Adipose-Derived Mesenchymal Stromal Cells Injected Systemically into Golden Retriever Muscular Dystrophy Dogs without Immunosuppression Are Able to Reach the Host Muscle and Express Human Dystrophin
Researchers demonstrate that injecting a huge quantity of human mesenchymal cells in a large animal model, without immunosuppression, is a safe procedure, which may have important applications for future therapy in patients with different forms of muscular dystrophies. [Cell Transplant] Abstract

Adipose Tissue-Derived Stem Cells Ameliorate Diabetic Bladder Dysfunction in a Type II Diabetic Rat Model
The aim of this study was to determine the efficacy and mechanism by which adipose tissue-derived stem cells may ameliorate diabetic bladder dysfunction in rats fed a high-fat diet and treated with low-dose streptozotocin to induce type II diabetes. [Stem Cells Dev] Abstract

Three-Dimensional Microtissue Formation of Undifferentiated Bone Marrow Mesenchymal Stem Cells Leads to Elevated Apoptosis
Researchers investigated the fate of cell tracker-labeled syngenic rat mesenchymal stem cells microtissue implants, injected into the scar area in a chronic rat myocardial infarction model. [Tissue Eng Part A] Abstract

Therapeutic Potential of In Utero Mesenchymal Stem Cell (MSC) Transplantation in Rat Fetuses with Spina Bifida Aperta
Researchers suggest that prenatal MSC transplantation could treat spinal neuron deficiency in neural tube defects by the regeneration of neurons and reduced spinal neuron death in the defective spinal cord. [J Cell Mol Med] Abstract

The Effect of the Addition of Adipose-Derived Mesenchymal Stem Cells to a Meniscal Repair in the Avascular Zone: An Experimental Study in Rabbits
The purpose of this study was to determine whether adipose-derived mesenchymal stem cells affect the healing rate of meniscal lesions sutured in the avascular zone in rabbits. [Arthroscopy] Abstract

Chitosan Enhances Mineralization During Osteoblast Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells, by Upregulating the Associated Genes
Researchers evaluated effects of chitosan-coated tissue culture plates on adhesion and osteoblast differentiation processes of human mesenchymal stem cells, isolated from adult bone marrow. [Cell Prolif] Abstract

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INDUSTRY NEWS

Roddenberry Foundation Gives $5 Million to Gladstone for Stem Cell Research
The Gladstone Institutes and the Roddenberry Foundation inaugurated the Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, a new unit founded on an unprecedented $5 million gift from the foundation that was established to honor the legacy of Star Trek creator Gene Roddenberry. [The J. David Gladstone Institute] Press Release

Mesoblast Cleared to Begin First Phase II Clinical Trial for Eye Diseases
Mesoblast Limited announced that it has received regulatory clearance from the Singapore Health Sciences Authority to commence the first Phase II trial of its proprietary allogeneic (off-the-shelf) adult stem cell therapy for patients with proliferation of leaky blood vessels in the eyes – neovascular Age-related Macular Degeneration. [Mesoblast Limited] Press Release

Biomedical Research Institute Establishes Center for Regenerative Therapeutics
The Biomedical Research Institute has assembled a critical mass of scientists to collaboratively build on recent developments in genomics, proteomics, stem cell biology, metabolic engineering, tissue engineering and microsystem fabrication. [Brigham and Women’s Hospital] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW International Society for Cellular Therapy 
June 5-8, 2012 
Seattle, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Quality Control Technologist – Cell Separation (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Mesenchymal Stem Cells & Scaffolds Fellowship (Università degli Studi di Genova)

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