Volume 3.45 | Nov 15

Mesenchymal Cell News 3.45, November 15, 2011
     In this issue: Publications Science News | Industry News | Policy News | Events | Jobs 
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TOP STORY
N-Cadherin Determines Individual Variations in the Therapeutic Efficacy of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in a Rat Model of Myocardial Infarction
To investigate the practical application of human umbilical cord blood-derived mesenchymal stem cells, researchers searched for surface signature molecules that could serve as indicators of therapeutic efficacy. [Mol Ther] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Mesenchymal Stem Cells Prime Proliferating Adult Neural Progenitors Towards an Oligodendrocyte Fate
Researchers investigated if soluble factors derived from mesenchymal stem cells are able to prime neural progenitors to the oligodendroglial fate under proliferation conditions. [Stem Cells Dev] Abstract

TNF-α Increases Bone Marrow Mesenchymal Stem Cell Migration to Ischemic Tissues
The objective of this study was to analyze the influence of TNF-α on rat mesenchymal stem cells (MSCs) and to assess feasibility of MSC transplantation to repair ischemic injury. [Cell Biochem Biophys] Abstract

Perivascular Human Endometrial Mesenchymal Stem Cells Express Pathways Relevant to Self-Renewal, Lineage Specification, and Functional Phenotype
The goal of this study was to determine the transcriptome and signaling pathways in endometrial mesenchymal stem cells to understand its functional phenotype. [Biol Reprod] Abstract

A Simple Elastic Membrane-Based Microfluidic Chip for the Proliferation and Differentiation of Mesenchymal Stem Cells under Tensile Stress
This work presents a simple membrane-based microfluidic chip for the investigation of proliferation and differentiation of mesenchymal stem cells under mechanical stimuli. [Electrophoresis] Abstract

Transplantation of Porcine Umbilical Cord Matrix Mesenchymal Stem Cells in a Mouse Model of Parkinson’s Disease
This present study compared mesenchymal stem cells derived from umbilical cord matrix with bone marrow of miniature pigs on their phenotypic profiles and ability to differentiate in vitro into osteocytes, adipocytes and neuron-like cells. [J Tissue Eng Regen Med] Abstract

Co-Culturing Mesenchymal Stem Cells from Bone Marrow and Periosteum Enhances Osteogenesis and Neovascularization of Tissue-Engineered Bone
This study showed that co-cultured human bone marrow stem cells and periosteal-derived stem cells results in a synergistic effect on osteogenic differentiation both in vitro and in vivo. [J Tissue Eng Regen Med] Abstract

Implantation of Biomaterial as an Efficient Method to Harvest Mesenchymal Stem Cells
In this study, researchers developed a new method to harvest mesenchymal stem cells. [Exp Biol Med] Abstract

Imaging of Human Mesenchymal Stromal Cells: Homing to Human Brain Tumors
Researchers compared three labeling techniques for their ability to track the migration of transplanted human mesenchymal stromal cells in an orthotopic mouse xenograft model. [J Neurooncol] Abstract

An Optimized Growth Factor Cocktail for Ovine Mesenchymal Stem Cells
In this study, researchers have evaluated five growth factors for their ability to initiate and support in vitro proliferation, migration, and invasion of ovine mesenchymal stem cells. [Growth Factors] Abstract

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SCIENCE NEWS

Halozyme’s Ultrafast Insulin Formulations Improved Postprandial Glycemic Control in Patients Living with Type 1 Diabetes: Phase II Study Results
Data from the Phase II study indicated that the Company’s recombinant human hyaluronidase enzyme reduced postprandial glycemic excursions, as well as significantly reduced hypoglycemic events. [Press release from Halozyme Therapeutics, Inc. discussing research presented at the American Diabetes Association’s 72nd Scientific Sessions, Philadelphia] Press Release

Interim Data From Pre-administration of Hylenex in Analog Insulin Pump Therapy Demonstrate Consistent Insulin Action Profile
Halozyme Therapeutics, Inc. presented results from a Phase IV study of Hylenex® recombinant (hyaluronidase human injection) in sensor augmented insulin analog pump (SAP) therapy in patients living with Type 1 diabetes. [Press release from Halozyme Therapeutics, Inc. discussing research presented at the American Diabetes Association’s 72nd Scientific Sessions, Philadelphia] Press Release

Stem Cell Society Singapore (SCSS) 2012 Symposium: Stem Cell Based Therapy

INDUSTRY NEWS

$100 Million Gift Establishes Belfer Research Building at Weill Cornell Medical College
In the presence of U.S. Congresswoman Carolyn B. Maloney, Weill Cornell Medical College dedicated the Belfer Research Building, a state-of-the-art facility that will more than double the Medical College’s existing research space and position Weill Cornell at the vanguard of new medical research and discoveries. [Weill Cornell Medical College] Press Release


Lentigen and UH Case Medical Center Initiate Phase I Trial Using Gene Therapy and Bone Marrow Stem Cells in the Treatment of Brain Cancer
University Hospitals (UH) Case Medical Center, Case Western Reserve University School of Medicine and Lentigen Corporation announced the initiation of a novel Phase I clinical trial of LG631 gene therapy for the protection of hematopoietic stem cells from the dose limiting toxicity of chemotherapy with Temodar. [University Hospitals] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Keystone Symposia on Molecular and Cellular Biology – Mechanisms of Whole Organ Regeneration
April 1-6, 2012
Breckenridge, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientific Marketing Communications Specialist (STEMCELL Technologies)

Mesenchymal Stem Cells & Scaffolds Fellowship (Università degli Studi di Genova)

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