Volume 4.10 | Mar 13

Mesenchymal Cell News 4.10, March 13, 2012
     In this issue: Publications Industry News | Policy News | Events | Jobs 
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TOP STORY
The A2B Adenosine Receptor Promotes Mesenchymal Stem Cell Differentiation to Osteoblasts and Bone Formation In Vivo
Here, researchers studied the role of the A2B adenosine receptor in the differentiation of mesenchymal stem cells to osteoblasts. [J Biol Chem] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Stem Cell-Derived Extracellular Matrix Enables Survival and Multi-Lineage Differentiation within Superporous Hydrogels
Researchers demonstrate the potential of human mesenchymal stem cells to alter the “blank” poly(ethylene glycol) diacrylate environment to a milieu conducive to cell growth and multi-lineage differentiation by secreting adhesive extracellular matrix proteins within the porous network of the superporous hydrogel scaffolds. [Biomacromolecules] Abstract

Development of Silk-Based Scaffolds for Tissue Engineering of Bone from Human Adipose Derived Stem Cells
In this study, researchers investigated a range of silk scaffolds for bone tissue engineering using human adipose-derived stem cells. [Acta Biomater] Abstract

Umbilical Cord Stem Cells Released from Alginate-Fibrin Microbeads Inside Macroporous and Biofunctionalized Calcium Phosphate Cement for Bone Regeneration
The objectives of this study were to develop a novel biofunctionalized and macroporous calcium phosphate cement (CPC) containing alginate-fibrin microbeads encapsulating human umbilical cord mesenchymal stem cells (hUCMSC) and, for the first time, investigate hUCMSC proliferation and osteogenic differentiation inside the CPC. [Acta Biomater] Abstract

Rat Bone Marrow Stromal Cells-Seeded Porous Gelatin/Tricalcium Phosphate/Oligomeric Proanthocyanidins Composite Scaffold for Bone Repair
The aim of this study was to prepare and evaluate the feasibility of a porous scaffold, which was composed of oligomeric proanthocyanidin crosslinked gelatin mixed with β-tricalcium phosphate and was seeded with bone marrow stromal cells as a bone substitute. [J Tissue Eng Regen Med] Abstract

Effect of Chondroitin Sulphate C on the In Vitro and In Vivo Chondrogenesis of Mesenchymal Stem Cells in Crosslinked Type II Collagen Scaffolds
This study evaluated the crosslinkage effect of chondroitin sulphate C and type II collagen on chondrogenesis of mesenchymal stem cells in vitro and in vivo. [J Tissue Eng Regen Med] Abstract

Artemisinic Acid Is a Regulator of Adipocyte Differentiation and CCAAT/Enhancer Binding Protein δ Expression
In this study, artemisinic acid, which was isolated from Artemisia annua L., inhibited adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells and its mechanism of action was determined. [J Cell Biochem] Abstract

Neural Differentiation of Umbilical Cord Mesenchymal Stem Cells by Sub-Sonic Vibration
In this study, the effects of sub-sonic vibration were examined by assessing the proliferation and differentiation properties of mesenchymal stem cells. [Life Sci] Abstract

Recellularized Nerve Allografts with Differentiated Mesenchymal Stem Cells Promote Peripheral Nerve Regeneration
Here, researchers aimed to determine whether bone-marrow-derived mesenchymal stem cell-Schwann cells or adipose-derived mesenchymal stem cell-Schwann cells are a promising cell type for enriching acellular grafts in nerve repair. [Neurosci Lett] Abstract

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INDUSTRY NEWS

BrainStorm Cell Therapeutics Expands Pipeline with the Initiation of a Study for Multiple Sclerosis
BrainStorm Cell Therapeutics Inc. announced plans to initiate a preclinical study assessing the efficacy of its NurOwn™ stem cell technology in patients with Multiple Sclerosis. The NurOwn™ technology processes adult human mesenchymal stem cells that are present in bone marrow and are capable of self-renewal as well as differentiation into many cell types. [BrainStorm Cell Therapeutics Inc.] Press Release

Alliance for Advanced Therapies to Officially Launch at BIO-Europe Spring® 2012
EBD Group announced that the Alliance for Advanced Therapies (AAT) will launch at the BIO-Europe Spring® 2012 partnering event. The ATT is a new organization devoted to supporting cell therapy, regenerative medicine and other potentially life-saving advanced therapeutics in Europe. [EBD Group AG] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Cell-Based Therapies & Tissue Engineering (CTTE) 2012: Cell-Based Therapies and Tissue Engineering
May 21-23, 2012
Cleveland, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Scientist – Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Research Associates/Scientist/Senior Scientist – Stem Cell Research (Advanced Cell Technology) 

Postdoctoral Position – Molecular Cell Biology (Weizmann Institute of Science) 

Postdoctoral Fellow (University of Rochester Medical Center)

Postdoctoral Fellow (Erasmus MC)


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