Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

Combined Transplantation of hiPSC-NSC and hMSC Ameliorated Neuroinflammation and Promoted Neuroregeneration in Acute Spinal Cord Injury

[Current Stem Cell Research & Therapy] To evaluate the therapeutic effects of combination cells, acute spinal cord injury mice model were established and combined transplantation of hiPSC-neural stem cells and human mesenchymal stem cells into the lesion site immediately after the injury.

Bioreactor-Based Stem Cell Therapy for Liver Fibrosis

[Biofabrication] 5% liver fibrosis serum was used to induce the therapeutic phenotype of MSCs, and a fluid bioreactor carrying a co-culture system of hepatocytes and MSCs was constructed to produce the therapeutic medium.

Osteopontin Rejuvenates Senescent Adipose-Derived Stem Cells and Restores their Bone Tissue Regenerative Function

[Stem Cell Reviews And Reports] The authors investigated if osteopontin modulated cell senescence and bone regenerative function in human adipose-derived mesenchymal stem cells, and to determine the underlying mechanisms.

TRPV4 Activator-Containing CMT-Hy Hydrogel Enhances Bone Tissue Regeneration In Vivo by Enhancing Mitochondrial Health

[ACS Biomaterials Science & Engineering] Scientists demonstrated that transient receptor potential cation channel subfamily V member 4 (TRPV4), a mechanosensitive, thermogated, and nonselective cation channel, was endogenously present in the MSCs.

Injectable Hydrogel to Deliver Bone Mesenchymal Stem Cells Preloaded With Azithromycin to Promote Spinal Cord Repair

[ACS Nano] The authors explored the potential of promoting repair in the injured spinal cord by delivering bone MSCs that had internalized nanoparticles preloaded with azithromycin.

ATRX Guards Against Aberrant Differentiation in Mesenchymal Progenitor Cells

[Nucleic Acids Research] Scientists showed in murine mesenchymal progenitor cells that had Atrx deficiency aberrantly activated mesenchymal differentiation programs. This included adipogenic pathways where ATRX loss induced expression of adipogenic transcription factors and enhanced adipogenic differentiation in response to differentiation stimuli.

Mesenchymal Stem Cell-Derived Exosomes Promote Recovery of The Facial Nerve Injury through Regulating Macrophage M1 and M2 Polarization by Targeting the P38 MAPK/NF-Κb Pathway

[Aging And Disease] Investigators explored the function of MSC-exosomes in the immunomodulation of macrophages and their effects in repairing facial nerve injury. An ultracentrifugation technique was used to separate exosomes from the MSC supernatant.

Human Umbilical Cord/Placenta Mesenchymal Stem Cell Conditioned Medium Attenuates Intestinal Fibrosis In Vivo and In Vitro

[Stem Cell Research & Therapy] Researchers investigated the anti-fibrogenic properties and mechanisms of the conditioned medium from human umbilical cord/placenta-derived MSCs in a murine intestinal fibrosis model and human primary intestinal myofibroblasts.

Adipose Tissue-Derived Mesenchymal Stem Cell Inhibits Osteoclast Differentiation through Tumor Necrosis Factor Stimulated Gene-6

[Tissue Engineering And Regenerative Medicine] Human adipose tissue-derived (AD) MSCs were co-cultured with bone marrow-derived monocyte/macrophage from DBA/1J or B6 mouse in the presence of osteoclastogenic condition. In some co-culture groups, ADMSCs were transfected with siRNA targeting TSG-6 or osteoprotegerin to determine their role in osteoclastogenesis.

Induced Pluripotent Stem Cell Derived Pericytes Respond to Mediators of Proliferation and Contractility

[Current Stem Cell Research & Therapy] Investigators differentiated iPSCs into iPericytes of either the mesoderm or neural crest lineage using established protocols. They compared iPericyte and human brain vascular pericytes (HBVP) morphologies, quantified gene expression by qPCR and bulk RNA sequencing, and visualised pericyte protein markers by immunocytochemistry.

Mesenchymal Stem/Stromal Cell Therapy for Radiation-Induced Xerostomia in Previous Head and Neck Cancer Patients: A Phase II Randomised, Placebo-Controlled Trial

[Clinical Cancer Research] The authors differentiated iPSCs into iPericytes of either the mesoderm or neural crest lineage using established protocols. They compared iPericyte and human brain vascular pericytes (HBVP) morphologies, quantified gene expression by qPCR and bulk RNA sequencing, and visualised pericyte protein markers by immunocytochemistry.

Cellcolabs Raises $8.7M to Make Stem Cells Cheaper for Novel Treatment Research

[Sifted] Cellcolabs has raised $8.7m from angel investors to expand production facilities and grow employee headcount. The Sweden-based company manufactures specialised stem cells that can be used to develop cell therapy treatments for diseases associated with inflammation.

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.

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