Volume 5.01 | Jan 15

Mesenchymal Cell News 5.01 January 15, 2013
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs 
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TOP STORY
Prostaglandin E2 Regulates Murine Hematopoietic Stem/Progenitor Cells Directly via EP4 Receptor and Indirectly through Mesenchymal Progenitor Cells
Bone marrow mesenchymal progenitor cells (MPCs) expressed EP receptors, and stimulation of MPCs with Prostaglandin E2 significantly increased their ability to support hematopoietic stem/progenitor cell colony formation. [Blood] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

Lipoprotein Receptor-Related Protein 5 Is a Coreceptor for Multiple Fibrogenic Signaling Pathways in Pericytes and Myofibroblasts that Are Inhibited by Dickkopf-Related Protein 1
Mesenchymal cells including microvascular mural cells (pericytes) are major progenitors of scar-forming myofibroblasts in kidney and other organs. Scientists showed pericytes in healthy kidneys have active WNT/β-catenin signaling responses that are markedly up-regulated following kidney injury. [Proc Natl Acad Sci USA] Abstract

The Homing of Bone Marrow MSCs to Non-Osseous Sites for Ectopic Bone Formation Induced by Osteoinductive Calcium Phosphate
Researchers used a sex-mismatched beagle dog model to investigate bone marrow mesenchymal stem cell (BMSC) homing via blood circulation to participate in ectopic bone formation via osteoinductive biomaterial. [Biomaterials] Abstract

Pharmacologically Active Microcarriers Influence VEGF-A Effects on Mesenchymal Stem Cell Survival
Vascular-endothelial-growth-factor-A (VEGF-A) or fibronectin-coated pharmacologically-active-microcarriers (FN-PAM-VEGF) could differently enhance cell proliferation, and/or resistance to hypoxia/reoxygenation of mesenchymal stem cells (MSCs). To test this hypothesis, MSCs were incubated for six-days with VEGF-A alone or with FN-PAM-VEGF. [J Cell Mol Med] Abstract

Effect of Labeling with Iron Oxide Particles or Nanodiamonds on the Functionality of Adipose-Derived Mesenchymal Stem Cells
The authors examined the effects of cell labeling on the in vitro functionality of human adipose-derived mesenchymal stem cells. [PLoS One] Full Article

Intranasal Mesenchymal Stem Cell Treatment for Neonatal Brain Damage: Long-Term Cognitive and Sensorimotor Improvement
Scientists analyzed long-term effects of intranasal mesenchymal stem cell treatment on lesion size, sensorimotor and cognitive behavior, and determined the therapeutic window and dose response relationships. [PLoS One] Full Article

Platelet-Derived Growth Factor-BB Accelerates Prostate Cancer Growth by Promoting the Proliferation of Mesenchymal Stem Cells
Investigators found that mesenchymal stem cells promoted prostate cancer (PCa) tumor growth in vivo and cell proliferation in vitro by using PCa cell strain RM-1. [J Cell Biochem] Abstract

Intra-Arterial Allogeneic Mesenchymal Stem Cells for Critical Limb Ischemia Are Safe and Efficacious: Report of a Phase I Study
Researchers evaluated 13 patients for a Phase I trial to investigate the safety and efficacy of intra-arterial mesenchymal stem cells in critical limb ischemia patients. [World J Surg] Abstract

Selective Isolation of Nanog-Positive Human Amniotic Mesenchymal Cells and Differentiation into Cardiomyocytes
Human amniotic mesenchymal cells (hAMCs) have the potential to be a useful cell source for cardiac regeneration therapy. Scientists attempted to isolate stem cells from hAMCs and differentiate them into cardiomyocytes. [Cell Reprogram] Abstract

Biomimetic Three-Dimensional Anisotropic Geometries by Uniaxial Stretch of Poly(ɛ-Caprolactone) Films for Mesenchymal Stem Cell Proliferation, Alignment, and Myogenic Differentiation
Investigators present a novel simple, solvent-free, and reproducible method via uniaxial stretching for incorporating anisotropic topographies on bioresorbable films with ambitions to realize stem cell alignment control. [Tissue Eng Part C Methods] Full Article | Press Release

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REVIEWS

Mesenchymal Stem Cell: Keystone of the Hematopoietic Stem Cell Niche and a Stepping-Stone for Regenerative Medicine
The authors examined the definition of mesenchymal stem cells and discuss the importance of rigorously characterizing their stem cell activity. They review their role and that of other putative niche constituents in the regulation of bone marrow hematopoietic stem cells. [Annu Rev Immunol] Abstract

The Potential Use of Mesenchymal Stem Cells in Hematopoietic Stem Cell Transplantation
The authors summarize advances in the potential use of mesenchymal stem cells (MSCs) in hematopoietic stem cell transplantation (HSCT). In addition, they discuss their use in clinical trials of the treatment of graft-versus-host disease following HSCT, the immunomodulatory capacity of MSCs, and their regenerative and therapeutic potential in the field of HSCT. [Exp Mol Med] Full Article

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INDUSTRY NEWS

Regenerative Medicine: Clinical Trials Launched for the Treatment of Ununited Fractures
The REBORNE project (Regenerating Bone Defects using New biomedical Engineering approaches), funded by the European Commission and coordinated by Inserm, has just received the green light from the French Medicinal Agency ANSM to begin orthopedic surgery clinical trials that aim to repair bones using adult stem cells combined with biomaterials. [INSERM] Press Release

SanBio Announces Enrollment of the Second Cohort of Patients in Its Clinical Trial of Stem Cell Therapy for Chronic Stroke
SanBio Inc. announced the successful enrollment of the second dose cohort of patients in its Phase I/IIa clinical trial testing the safety and efficacy of a novel allogeneic stem cell therapy product, SB623, in patients suffering from chronic deficits resulting from previous stroke injuries. [PR Newswire Association LLC]
Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Israstem 2013
April 22-23, 2013
Ramat Gen, Israel

Visit
our events page to see a complete list of events in the mesenchymal cell community.

JOB OPPORTUNITIES

Scientist or Engineer – hPSC Bioengineer (STEMCELL Technologies, Inc.)

Postdoctoral Position – Tumorigenicity of Mesenchymal Stem Cells (Weizmann Institute of Science)

PhD Student – Stem Cells in Tooth Regeneration (King’s College London)

PhD Studentship – Towards a Steering of Inflammatory Processes in Bone Regeneration (Charite – Universitatsmedizin Berlin)

Postdoctoral Position – Mouse Developmental Biology (Lund Stem Cell Center, Lund University)

Postdoctoral Position – Stem Cell Biology (Johns Hopkins School of Medicine)

Postdoctoral Position – Human Stem Cell Engineering (University of Wisconsin – Madison)


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