Mechanical Memory and Dosing Influence Stem Cell Fate
Researchers found that the activation of the Yes-associated protein and transcriptional coactivator with PDZ-binding domain as well as the pre-osteogenic transcription factor RUNX2 in human mesenchymal stem cells cultured on soft poly(ethylene glycol) hydrogels depended on previous culture time on stiff tissue culture polystyrene. [Nat Mater]
Abstract|Editorial
Development of a Dynamic Stem Cell Culture Platform for Mesenchymal Stem Cell Adhesion and Evaluation
The authors have developed a device, the dynamic stem cell culture platform, consisting of a biomimetic scaffold cultured within the dynamic environment of a perfusion bioreactor. By varying scaffold parameters including stiffness and protein inclusion at the material surface, they found that mesenchymal stem cells were able to adhere to modified substrates, while still maintaining multipotency. [Mol Pharm]
Abstract
Mesenchymal Stem Cells, Cancer Challenges and New Directions
The authors focus on the therapeutic potential of the human mesenchymal stem cells (hMSC) with special focus on their use in cancer therapy. They consider different mechanisms, by which stem cells can maintain telomeres and thereby the cell’s ability to be expanded in vitro, and also focus on a new therapeutic venue that utilizes hMSCs as delivery vehicles in innovative new cancer treatments. [Eur J Cancer]
Abstract
Exosomes Derived from Mesenchymal Stem Cells
Compared with cells, exosomes are more stable and reservable, have no risk of aneuploidy, a lower possibility of immune rejection following in vivo allogeneic administration, and may provide an alternative therapy for various diseases. In this review, the authors summarize the properties and biological functions of mesenchymal stem cell-derived exosomes and discuss the related mechanisms. [Int J Mol Sci]
Abstract|Download Full Article
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INDUSTRY NEWS
Stem Cell Therapy May Help Severe Congestive Heart Failure
A multi-site study is being conducted, in which stem cells are removed from the bone marrow, their numbers significantly increased by technology developed by Aastrom Biosciences, then injected into multiple weak points in the heart. [Medical College of Georgia at Georgia Regents University]
Press Release
AIM Receives $1 Million Gift to Advance Stem Cell Research
Inaugurating a new era of philanthropic giving for stem cell research in Alabama, the Alabama Institute of Medicine (AIM) announced the generous donation of $1 Million dollars from an anonymous Birmingham resident. [Alabama Institute of Medicine]
Press Release
STEMSOFT Announces Release of New BMT Clinic Software Solution
STEMSOFT™ Software Inc. announced the release of a new BMT cellular therapy transplant software solution, STEMSOFT CLINIC. This new system efficiently manages all patient and donor information in one location complete with an available BMT registry submission and retrieval process for all available forms using the CIBMTR AGNIS system. [STEMSOFT™ Software Inc.]
Press Release
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