Volume 6.32 | Aug 26

Mesenchymal Cell News 6.32 August 26, 2014
Mesenchymal Cell News
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Mesenchymal Stem/Stromal Cells Protect the Ocular Surface by Suppressing Inflammation in an Experimental Dry Eye
Scientists investigated the therapeutic potential of mesenchymal stem/stromal cells in a murine model of an inflammation-mediated dry eye that was induced by an intraorbital injection of concanavalin A. [Mol Ther] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
GATA2 Regulates Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells
Investigators established bone marrow mesenchymal stem cells from GATA2 conditional knockout mice. Differentiation of GATA2-deficient bone marrow mesenchymal stem cells into adipocytes induced accelerated oil-drop formation. [Haematologica] Abstract | Full Article

MicroRNA-302 Induces Proliferation and Inhibits Oxidant-Induced Cell Death in Human Adipose Tissue-Derived Mesenchymal Stem Cells
Scientists screened microRNAs that affected the proliferation and survival of human adipose tissue-derived mesenchymal stem cells (hADSCs). Transfection of miR-302d mimic increased cell proliferation and protected cells from oxidant-induced cell death in hADSCs, which was supported by flow-cytometric analysis. [Cell Death Dis] Full Article

Transplantation of Mesenchymal Stem Cells into the Renal Medulla Attenuated Salt-Sensitive Hypertension in Dahl S Rat
Investigators detected a stem cell deficiency in the renal medulla in Dahl salt-sensitive (S) rats and then tested the hypothesis that transplantation of mesenchymal stem cells into the renal medulla improves salt-sensitive hypertension in Dahl S rats. [J Mol Med] Abstract

Molecular Pathways Reflecting Poor Intrauterine Growth Are Found in Wharton’s Jelly-Derived Mesenchymal Stem Cells
Mesenchymal stem cells from small for gestational age newborns were found to express an altered EGR-1-dependent gene network involved in the regulation of cell proliferation and oxidative stress. [Hum Reprod] Abstract

Rapidly Self-Renewing Human Multipotent Marrow Stromal Cells (hMSC) Express Sialyl Lewis X and Actively Adhere to Arterial Endothelium in a Chick Embryo Model System
There have been conflicting observations regarding the receptors utilized by hMSCs to adhere to endothelial cells. To address the discrepancies, investigators performed experiments with cells prepared with a standardized, low-density protocol preserving a sub-population of small cells that are rapidly self-renewing. [PLoS One] Full Article

MCP/CCR2 Signaling Is Essential for Recruitment of Mesenchymal Progenitor Cells during the Early Phase of Fracture Healing
The functional effect of monocyte chemotactic protein-1 (MCP-1) on primary mouse bone marrow stromal cells was evaluated using an in vitro migration assay. MCP-1-/- and C-C chemokine receptor 2 (CCR2)-/- mice were fractured and evaluated by histological staining and micro-computed tomography. [PLoS One] Full Article

Effect of Preemptive Treatment with Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells on the Development of Renal Ischemia-Reperfusion Injury in Mice
Investigators hypothesized that human umbilical cord blood-derived stem cells could suppress the inflammatory response in postischemic kidneys and attenuate early renal injury. [Am J Physiol Renal Physiol] Abstract

Mesenchymal Stem Cells from Osteoporotic Patients Reveal Reduced Migration and Invasion upon Stimulation with BMP-2 or BMP-7
Researchers scrutinized human mesenchymal stem cells for osteoporosis associated alterations in bone morphogenetic protein (BMP) mediated migration and invasion as well as in extracellular matrix binding integrin expression. [Biochem Biophys Res Commun] Full Article

MSC Attenuate Diabetes-Induced Functional Impairment in Adipocytes via Secretion of Insulin-Like Growth Factor-1
Researchers hypothesized that mesenchymal stem cell (MSC) function may involve subcutaneous adipocytes. The abnormal function of subcutaneous adipocytes from STZ induced diabetic mice including glucose uptake and free fatty acid secretion level were assessed. [Biochem Biophys Res Commun] Abstract

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“Mesenchymal” Stem Cells
Two opposing descriptions of so-called mesenchymal stem cells (MSCs) exist at this time. One sees MSCs as the postnatal, self-renewing, and multipotent stem cells for the skeleton. In the alternative description, MSCs are ubiquitous in connective tissues and are defined by in vitro characteristics and by their use in therapy, which rests on their ability to modulate the function of host tissues rather than on stem cell properties. The author discusses how the two views developed, conceptually and experimentally, and attempt to clarify the confusion arising from their collision. [Annu Rev Cell Dev Biol] Abstract

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BioProcess International Conference & Exhibition - Boston MA
Regeneus and Cryosite Partner for the Development and Manufacture of Human Stem Cell Products
Regeneus and Cryosite announced that they have signed an agreement to collaborate on the development and manufacture of new stem cell products for human applications. [Regeneus Inc.] Press Release

Osteoarthritis Cell Therapy, HiQCell, Shows Continuing Significant Patient Improvements at Two Years Post-Treatment
Regeneus announced further results from the clinical research study that is tracking the safety and effectiveness of its innovative cell therapy, HiQCell, in the treatment of osteoarthritis. [Regeneus Inc.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Till & McCulloch Meetings
October 27-29, 2014
Ottawa, Canada

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Mesenchymal Stromal/Stem Cell Scientist (UHN Arthritis Program)

NEW Researcher – Phenotypic and Functional Characterization of Adult Stem/Stromal Cells from Bone Marrow and Adipose Tissue (Etablissement Français du Sang Pyrénées-Méditerranée)

PhD Position – Tissue Engineering and Stem Cell Biology (Dublin City University)

Postdoctoral Fellow – Intestinal Immunology (BSRC Fleming)

Postdoctoral Position – Biomaterials/Cartilage Regeneration (Peking University)

Postdoctoral Fellowship – Developing Applications of Mesenchymal Stromal/Stem Cells in Hematopoietic Cell Transplantation (The Research Institute at Nationwide Children’s Hospital)

Postdoctoral Positions – Tissue Engineering and Regenerative Medicine (University of the Andes)

Technical Account Manager (GlobalStem)

Scientist – Mesenchymal Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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