Volume 6.37 | Sep 30

Mesenchymal Cell News 6.37 September 30, 2014
Mesenchymal Cell News
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The Neural Crest Is a Source of Mesenchymal Stem Cells with Specialized Hematopoietic Stem-Cell-Niche Function
The authors demonstrate that different mesenchymal stem cells (MSCs) populations in the developing marrow of long bones have distinct functions. Proliferative mesoderm-derived nestin- MSCs participate in fetal skeletogenesis, and lose MSC activity soon after birth. [eLife] Abstract | Download Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Melatonin Enhances the Human Mesenchymal Stem Cells Motility via Melatonin Receptor 2 Coupling with Gαq in Skin Wound Healing
In a mouse skin excisional wound model, scientists found that transplantation of umbilical cord blood mesenchymal stem cells (UCB-MSCs) pre-treated with melatonin enhanced wound closure, granulation, and re-epithelialization at mouse skin wound sites, where relatively more UCB-MSCs which were engrafted onto the wound site were detected. [J Pineal Res] Abstract

TRPM7 Senses Mechanical Stimulation Inducing Osteogenesis in Human Bone Marrow Mesenchymal Stem Cells
Using fluorescence and laser confocal microscopy as well as patch clamp techniques, investigators identified the transient receptor potential melastatin type 7 (TRPM7) channel as the key channel involved in mechanotransduction in bone marrow mesenchymal stem cells. [Stem Cells] Abstract

Mesenchymal Stem Cells with Increased SDF-1 Expression Enhanced Fracture Healing
In a rat defect bone model, bone marrow mesenchymal stem cells over-expressing SDF-1 showed significantly more new bone formation within the gap and less bone mineral loss at the area adjacent to the defect site during the early bone healing stage than non-transfected cells. [Tissue Eng Part A] Abstract

Impaired Endothelium-Mesenchymal Stem Cells Cross-Talk in Systemic Sclerosis: A Link Between Vascular and Fibrotic Features
Scientists investigated different angiogenic and profibrotic molecules in a tridimensional matrigel assay, performing co-cultures with endothelial cells and bone marrow derived mesenchymal stem cells from patients and healthy controls. [Arthritis Res Ther] Abstract | Full Article

Lithium Stimulates Human Bone Marrow-Derived Mesenchymal Stem Cell Proliferation through GSK-3-Beta-Dependent Beta-Catenin/Wnt Pathway Activation
Scientists show for the first time that lithium, a well-known antidepressant, reversibly promoted the proliferation of human bone marrow-derived mesenchymal stem cells (MSC) in vitro. MSC treated with 5 mM lithium proliferated more rapidly than untreated cells without undergoing apoptosis. [FEBS J] Abstract

MicroRNA-377 Regulates Mesenchymal Stem Cell-Induced Angiogenesis in Ischemic Hearts by Targeting VEGF
Using microRNA microarray analysis, investigators identified a microRNA expression profile in hypoxia-treated mesenchymal stem cells and observed that among all dysregulated microRNAs, microRNA-377 was decreased the most significantly. [PLoS One] Full Article

Tissue-Engineered Tracheal Reconstruction Using Mesenchymal Stem Cells Seeded on a Porcine Cartilage Powder Scaffold
Researchers investigated the plausibility of using mesenchymal stem cells seeded on a porcine cartilage powder scaffold for tracheal defect repair. After seven weeks culture, the tracheal implants were transplanted on a 5 × 10 mm tracheal defect in six rabbits. [Ann Biomed Eng] Abstract

Fibroblast Growth Factor-2 Alone as an Efficient Inducer for Differentiation of Human Bone Marrow Mesenchymal Stem Cells into Dopaminergic Neurons
The reported efficiency of differentiation of human bone marrow derived mesenchymal stem cells (hBM-MSC) into dopaminergic neurons with different inducers is found to vary. Scientists investigated the response of hBM-MSCs to some of the neuronal inducers and their combinations. [J Biomed Sci] Abstract | Full Article

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Diversity in TAF Proteomics: Consequences for Cellular Differentiation and Migration
The authors focus on the role of TATA-box associated factor 4 (TAF4) and its functional isoforms generated by alternative splicing in controlling lineage-specific differentiation of normal mesenchymal stem cells and cancer stem cells. [Int J Mol Sci] Abstract | Download Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
Sumitomo Dainippon Pharma, SanBio to Jointly Develop SB623 in the U.S. and Canada
Sumitomo Dainippon Pharma Co., Ltd. and SanBio Co., Ltd. announced that the two companies have entered into a joint development and license agreement for exclusive marketing rights in the U.S. and Canada for SB623. SB623 is a novel cell therapy product derived from bone marrow mesenchymal stem cells obtained from healthy adult donors. [Sumitomo Dainippon Pharma Co., Ltd.] Press Release

Regeneus’ Osteoarthritis Cell Therapy, HiQCell, to Launch in Singapore
Regeneus Ltd. announced plans to open the HiQCell Regenerative Medicine Clinic in Singapore, and the appointment of leading specialist sports physician, Dr. Patrick Goh, as Medical Director. Through the clinic, Goh will provide patients in Singapore with access to Regeneus’ HiQCell, an innovative cell therapy for the treatment of osteoarthritis, with first treatments expected to commence in late 2014. [Regeneus Ltd.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 4th Joint Meeting of European Calcified Tissue Society (ECTS) and International Bone and Mineral Society (IBMS)
April 25-28, 2015
Rotterdam, The Netherlands

NEW Clinical Translation of Stem Cell Extracellular Vesicles
November 3-4, 2014
Singapore, Singapore

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Postdoctoral Position – Epigenetics in Aging, Osteoporosis and Stem Cells (Aachen University Medical School)

NEW Postdoctoral Fellow – Chondrocyte Differentiation and Its Role in Osteoarthritis (NYU Langone Medical Center)

Faculty Positions – Stem Cells and Regenerative Medicine (Baylor College of Medicine)

Postdoctoral Fellowship – Epigenetic Regulation of Cell Fate and Metabolism (University Medical Center Freiburg)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Mesenchymal Stem/Stromal Cells Characterization (INSERM)

Mesenchymal Stromal/Stem Cell Scientist (UHN Arthritis Program)

Researcher – Phenotypic and Functional Characterization of Adult Stem/Stromal Cells from Bone Marrow and Adipose Tissue (Etablissement Français du Sang Pyrénées-Méditerranée)

Scientist – Mesenchymal Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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