Volume 7.39 | Oct 6

Mesenchymal Cell News 7.39 October 6, 2015
Mesenchymal Cell News
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Hypoxia Differentially Modulates the Genomic Stability of Clinical-Grade ADSCs and BM-MSCs in Long-Term Culture
Investigators evaluated the occurrence of DNA damage and repair events during the ex vivo expansion of clinical-grade adipose-derived stromal cells (ADSCs) and bone marrow (BM)-derived mesenchymal stromal/stem cells (MSCs) cultured with platelet lysate under 21% or 1% O2 conditions. [Stem Cells] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Systemic Delivery of HER2-Retargeted Oncolytic-HSV by Mesenchymal Stromal Cells Protects from Lung and Brain Metastases
Scientists report that mesenchymal stromal cells (MSCs) from different sources can be forcedly infected with a HER2-retargeted oncolytic herpes simplex virus (HSV). Progeny virus spread from MSCs to cancer cells in vitro and in vivo. [Oncotarget] Full Article

Manufacture of Clinical-Grade Human Clonal Mesenchymal Stem Cell Products from Single Colony Forming Unit-Derived Colonies Based on the Subfractionation Culturing Method
The authors previously developed an alternative isolation and culture protocol for establishing a population of clonal mesenchymal stem cells (cMSCs) from single colony forming unit-derived colonies. In this study, they established a good manufacturing practice-compatible procedure for the clinical-grade production of human bone marrow-derived cMSCs based on the subfractionation culturing method. [Tissue Eng Part C Methods] Abstract

TGF-β3 and IGF-1 Synergy Ameliorates Nucleus Pulposus Mesenchymal Stem Cell Differentiation towards the Nucleus Pulposus Cell Type through MAPK/ERK Signaling
The authors investigated the synergy between transforming growth factor beta 3 (TGF-β3) and insulin-like growth factor 1 (IGF-1) on nucleus pulposus-derived mesenchymal stem cells and the underlying mechanism using a serum-free culture system. [Growth Factors] Abstract

Modulation of Cationicity of Chitosan for Tuning Mesenchymal Stem Cell Adhesion, Proliferation, and Differentiation
Researchers modulated the cationicity of chitosan to influence the mesenchymal stem cell (MSC) responses in terms of cell adhesion, proliferation, and differentiation. They indicated that the cationicity exerted a striking modulation effect on various MSC responses. [Biointerphases] Full Article

Characterization of Mesenchymal Stem Cells in Sheep Naturally Infected with Scrapie
Researchers analyze the properties of mesenchymal stem cells (MSCs) obtained from bone marrow and peripheral blood of sheep naturally infected with scrapie, a large mammal model for the study of prion diseases. After three passages of expansion, MSCs derived from scrapie animals displayed similar adipogenic, chondrogenic and osteogenic differentiation ability than cells from healthy controls; although a subtle decrease in the proliferation potential was observed. [J Gen Virol] Abstract

Stanniocalcin 2 Enhances Mesenchymal Stem Cell Survival by Suppressing Oxidative Stress
The stanniocalcin 2 (STC2) gene was transfected into two kinds of stem cells to prolong cell survival and protect the cells from the damage by oxidative stress. The stem cells expressing STC2 exhibited increased cell viability and improved cell survival as well as elevated expression of the pluripotency and self-renewal markers under sub-lethal oxidative conditions. [BMB Rep] Abstract | Download Full Article

The Impact of Hypoxia on Mesenchymal Progenitor Cells of Human Skeletal Tissue in the Pathogenesis of Heterotopic Ossification
Mesenchymal progenitor cells from human normal and heterotopic ossification (HO) skeletal tissue were cultivated under normoxia and hypoxia. Gene expression of factors which have a key role in HO etiology were examined by real-time PCR. [Int Orthop] Abstract

Rho/Rock Signal Transduction Pathway Is Required for MSC Tenogenic Differentiation
As the Rho/ROCK signal transduction pathway plays a critical role in both stress fiber formation and in cell sensation, scientists examined whether the activation of this pathway was required when inducing mesenchymal stem cell (MSC) tendon differentiation using rope-like silk scaffolds. [Bone Res] Full Article

Mesenchymal Stromal Cells Support Endothelial Cell Interactions in an Intramuscular Islet Transplantation Model
Scientists extended a previously published in vitro model of mesenchymal stromal cell (MSC)-islets in an experimental setting of islet transplantation to the abdominal muscle. Human islets coated with luciferase-GFP transduced human MSC were transplanted to the abdomen muscle tissue of NOD-scid ILR2γnull mice and cellular interactions were investigated by confocal microscopy. [Regen Med Res] Full Article

Learn How to Assemble & Purge the Hypoxia Chamber Watch the Video
Clinical Trials with Mesenchymal Stem Cells: An Update
The authors provide a comprehensive review of mesenchymal stem cell (MSC)-based clinical trials conducted worldwide that scrutinizes MSCs’ biological properties, elucidates recent clinical findings and clinical trial phases of investigation, highlights MSCs’ therapeutic effects, and identifies principal criticisms of the use of these cells. [Cell Transplant] Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.
Commence Bio to Present at 2015 Stem Cell Meeting on the Mesa
Commence Bio, Inc., a biotechnology company focused on the development of MSC1 and MSC2 cellular immunotherapy platforms for cancer and inflammatory diseases, announced that Thomas Isett, Chief Executive Officer and Co-Founder, will present a corporate overview. [Press release from Commence Bio discussing research presented at the 2015 Stem Cell Meeting on the Mesa (SCMOM), La Jolla] Press Release

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Osiris Announces Initiation of a Phase III Trial for a New Investigational Drug, OTI-15-01, for the Treatment of Chronic Diabetic Foot Wounds
Osiris Therapeutics, Inc. announced the initiation of its multicenter, randomized, blinded study with an open-label extension option to evaluate the safety and efficacy of OTI-15-01 for the treatment of chronic diabetic foot ulcers. [Osiris Therapeutics, Inc. (Business Wire)] Press Release

MSK’s Lorenz Studer Named a 2015 MacArthur Fellow
Memorial Sloan Kettering developmental biologist Lorenz Studer has been named a 2015 MacArthur Fellow by the John D. and Catherine T. MacArthur Foundation. [Gerstner Sloan Kettering Graduate School of Biomedical Sciences] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Keystone Symposia – Cardiac Development, Regeneration and Repair
April 3-7, 2016
Snowbird, United States

Visit our events page to see a complete list of events in the mesenchymal cell community.
NEW Postdoctoral Position – Bone Research (Weill Cornell College of Medicine)

NEW Postdoctoral Position – Stem Cell Research (Karolinska Institute)

Postdoctoral Researcher – Immune Response in Allo-Transplantation (NUI Galway)

Assistant Professor – Stem Cell Biology (University of South Carolina)

Senior Stem Cell Scientist (Medicines and Healthcare Products Regulatory Agency)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Faculty Position – Life Sciences (Stowers Institute for Medical Research)

Faculty Positions – Stem Cells and Regenerative Medicine (King Abdullah University of Science and Technology)

Postdoctoral Fellow – Cardiovascular Stem Cell Biology and Tissue Engineering (Yale University)

Junior Group Leader – Cell and Development Biology Program (Centre for Genomic Regulation)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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