Volume 7.48 | Dec 8

Mesenchymal Cell News 7.48 December 8, 2015
Mesenchymal Cell News
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KIT D816V Mutated Bone Marrow Mesenchymal Stem Cells in Indolent Systemic Mastocytosis Are Associated with Disease Progression
Scientists investigated the potential involvement of bone marrow mesenchymal stem cells from indolent systemic mastocytosis patients by the KIT D816V mutation and its potential impact on disease progression and outcome. [Blood] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

Murine Mesenchymal Stem Cell Commitment to Differentiation Is Regulated by Mitochondrial Dynamics
Little is known regarding the impact of mitochondrial dynamics on the differentiation process. Scientists addressed this knowledge gap by isolating mesenchymal stem cells from Swiss female mice, inducing these cells to differentiate into osteo, chondro and adipocytes and measuring changes in mass, morphology, dynamics and bioenergetics. [Stem Cells] Abstract

The Lineage Specification of Mesenchymal Stem Cells Is Directed by the Rate of Fluid Shear Stress
Scientists showed 0-0′ facilitated mesenchymal stem cell differentiation towards chondrogenic and not osteogenic phenotype, by promoting moderate intracellular calcium concentration increase from the calcium channels with the exception of mechanosensitive, cation-selective channels or intracellular calcium stores, and F-actin organization. [J Cell Physiol] Abstract

Systematic Microcarrier Screening and Agitated Culture Conditions Improves Human Mesenchymal Stem Cell Yield in Bioreactors
Researchers systematically evaluated 13 microcarriers for human bone marrow-derived mesenchymal stem cell expansion from three donors to establish a reproducible and transferable methodology for microcarrier selection. [Biotechnol J] Abstract

Promotion of Human Mesenchymal Stem Cell Osteogenesis by PI3-Kinase/Akt Signaling, and the Influence of Caveolin-1/Cholesterol Homeostasis
The authors hypothesized that focal adhesion signaling pathways such as PI3K/Akt signaling may be negatively regulated by caveolin-1 during human mesenchymal stem cell osteogenesis. [Stem Cell Res Ther] Full Article

A Robust Potency Assay Highlights Significant Donor Variation of Human Mesenchymal Stem/Progenitor Cell Immune Modulatory Capacity and Extended Radio-Resistance
The authors established a robust immunomodulation potency assay based on pooling responder leukocytes to minimize individual immune response variability. Comparing various mesenchymal stem/progenitor cells revealed significant potency inconsistency and generally diminished allo-immunosuppression compared to dose-dependent inhibition of mitogenesis. [Stem Cell Res Ther] Full Article

Canine and Equine Mesenchymal Stem Cells Grown in Serum Free Media Have Altered Immunophenotype
Investigators aimed to determine if specific mesenchymal stem cell (MSC) culture conditions, MSC expansion in HYPERFlasks® or MSC expansion in a commercially available serum-free media, would alter MSC proliferation, phenotype or immunomodulatory properties in vitro. [Stem Cell Rev] Full Article


Human Embryonic Stem Cell-Derived Mesenchymal cells Preserve Kidney Function and Extend Lifespan in NZB/W F1 Mouse Model of Lupus Nephritis
Investigators showed that human embryonic stem cell-mesenchymal stromal cells prevent the progression of fatal lupus nephritis in NZB/W F1 mice. Treatment led to statistically significant reductions in proteinuria and serum creatinine and preserved renal architecture. [Sci Rep] Full Article | Press Release

Contribution and Mobilization of Mesenchymal Stem Cells in a Mouse Model of Carbon Tetrachloride-Induced Liver Fibrosis
Hepatic fibrosis is associated with bone marrow derived mesenchymal stem cells (MSCs). Researchers aimed to determine what role MSCs play in the process and how they mobilize from bone marrow. [Sci Rep] Full Article

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The Challenges and Promises of Allogeneic Mesenchymal Stem Cells for Use as a Cell-Based Therapy
The authors first summarize the unique advantages of allogeneic mesenchymal stem cells (MSCs) for therapeutic applications. Second, they critically analyze the factors influencing their therapeutic effects, including administration routes, detection time-points, disease models, differentiation of MSCs in vivo, and timing and dosage of MSC administration. Finally, current approaches to allogeneic MSC application are discussed. [Stem Cell Res Ther] Full Article

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BrainStorm Awarded Additional $735,000 Non-Dilutive Grant for 2015 from Israel’s Office of the Chief Scientist
BrainStorm Cell Therapeutics Inc. announced that its wholly-owned subsidiary, Brainstorm Cell Therapeutics Ltd., has been awarded an additional grant of approximately $735,000 from Israel’s Office of the Chief Scientist. [BrainStorm Cell Therapeutics Inc. (PR Newswire Association LLC)] Press Release

BrainStorm Cell Therapeutics Announces Appointment of Dr. Revital Geffen-Aricha as Vice President of Research & Development
BrainStorm Cell Therapeutics Inc. announced that it has appointed Dr. Revital Geffen-Aricha, M.Sc., Ph.D., as Vice President of Research and Development. [BrainStorm Cell Therapeutics Inc.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW International Society for Stem Cell Research (ISSCR) 2016 Annual Meeting
June 22-25, 2016
San Francisco, United States

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NEW Postdoctoral Fellow – Therapy for Ischemic Heart Disease (University Health Network)

NEW Postdoctoral Position – Heart Regenerative Medicine (Karolinska Institutet)

Postdoctoral Fellow – Cellular Genetic Programme (Wellcome Trust Sanger Institute)

Postdoctoral Position – Organogenesis and Mesenchymal Stem Cells (University of Southern California)

Postdoctoral Fellows – Cardiovascular Biology and Regenerative Medicine (Icahn School of Medicine at Mount Sinai)

Faculty Positions – Stem Cell Biology (Albert Einstein College of Medicine)

Assistant or Associate Professor – Cell and Regenerative Biology (University of Wisconsin – Madison)

Postdoctoral Positions – Regenerative Biology and Medicine (Helmholtz Association)

Postdoctoral Fellowship – Developmental Cell Biology and Regenerative Medicine (University of California San Francisco)

Postdoctoral Fellow/Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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